
2026-04-09
Chiwindi chimayambitsa mu 2026 makamaka amaphatikizapo matenda aakulu a hepatitis B ndi C, matenda a chiwindi okhudzana ndi mowa, matenda a chiwindi a mafuta osaledzeretsa (NAFLD), komanso kukhudzana ndi aflatoxins. Ku China, chomwe chimayambitsa matenda a Hepatitis B, chomwe chimayambitsa chithandizo chamankhwala chapadera chomwe chimaphatikiza chithandizo chamankhwala chapamwamba, kuchotseratu maopaleshoni olondola, komanso inshuwaransi zadziko zotsika mtengo. Kumvetsetsa zomwe zimayambitsa izi ndizofunikira kwambiri kuti munthu azindikire msanga komanso kupeza chithandizo chamankhwala chaposachedwa chamitundumitundu chomwe chili m'zipatala zazikulu zaku China.
Etiology of hepatocellular carcinoma (HCC) yasintha, komabe matenda a chiwindi a virus akadali oyendetsa padziko lonse lapansi makamaka ku Asia. Mu 2026, mgwirizano wazachipatala ukuwonetsa kusintha komwe zinthu za metabolic zikukwera mwachangu motsatira zomwe zimayambitsa ma virus.
Kutenga kachilombo ka Hepatitis B (HBV) ndi chimodzi mwazomwe zimayambitsa khansa ya chiwindi ku China. Mosiyana ndi mayiko a Kumadzulo kumene Hepatitis C kapena mowa ndizofala kwambiri, HBV imayambitsa matenda ambiri m'deralo. Kachilomboka kamaphatikizana ndi ma genome, kumayambitsa kutupa kosatha komanso matenda a cirrhosis, omwe pamapeto pake amabweretsa kusintha koyipa.
Malangizo aposachedwa akugogomezera kuti kutsika kwa viremia mwa odwala omwe amathandizidwa ndi ma nucleos(t)ide analogues atha kukhalabe pachiwopsezo. Kafukufuku wofalitsidwa koyambirira kwa 2026 akuwonetsa kuti ngakhale odwala omwe ali pamzere woyamba wamankhwala amatha kukhala ndi viremia yotsika, zomwe zimafunikira kuwunika mosamala kuti apewe kukula kwa khansa.
Choyambitsa chomwe chikukula mwachangu cha khansa ya chiwindi mu 2026 ndi Non-Alcoholic Fatty Liver Disease (NAFLD), yomwe nthawi zambiri imatchedwa Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Pamene kusintha kwa moyo kukuchitika ku China, kunenepa kwambiri komanso mtundu wa 2 shuga wakula.
Kusintha kwa kagayidwe kachakudyaku kukupanga kuchuluka kwa anthu odwala khansa ya chiwindi omwe alibe kachilombo ka hepatitis. Njirayi imaphatikizapo kutupa kosalekeza kosalekeza komanso kupsinjika kwa okosijeni mkati mwa mafuta a chiwindi. Izi zikuwonetsa zochitika zapadziko lonse lapansi koma zikuchulukirachulukira m'matawuni aku China chifukwa chakusintha kwazakudya komanso moyo wongokhala.
Kumwa mowa mopitirira muyeso kukupitirizabe kukhala kothandiza kwambiri. Mowa amachita synergistically ndi tizilombo chiwindi, kwambiri kuchulukitsa chiopsezo HCC. Wodwala akakhala ndi HBV yosatha komanso kumwa mowa mopitirira muyeso, mwayi woti akudwala khansa umachulukirachulukira poyerekeza ndi kukhala ndi chiopsezo chokhacho.
Kuphatikiza apo, kupezeka kwazakudya ku ma aflatoxins, mankhwala oopsa omwe amapangidwa ndi nkhungu pambewu ndi mtedza wosasungidwa bwino, kumakhalabe nkhawa m'madera ena. Aflatoxin B1 ndi carcinogen yamphamvu yomwe imayambitsa masinthidwe amtundu wa TP53 chotupa suppressor gene. Ngakhale kuti malamulo a chitetezo cha chakudya akuyenda bwino, chilengedwechi chikuthandizirabe kufalikira kwa matenda m'madera akumidzi.
China yakhala mtsogoleri wapadziko lonse lapansi pakufufuza za khansa ya chiwindi ndi chithandizo chamankhwala. Kutulutsidwa kwa Kuzindikira Khansa Yachiwindi Yoyambira ndi Malangizo Othandizira (2026 Edition) zimasonyeza chochitika chofunika kwambiri. Malangizowa amaphatikiza umboni wapamwamba kwambiri wochokera ku mayesero azachipatala otsogozedwa ndi China, omwe amapereka "National Solution" yogwirizana ndi miliri yeniyeni ya dera.
Zotulutsidwa koyambirira kwa 2026, zitsogozo zosinthidwa zadziko zikugogomezera machitidwe ozikidwa paumboni ozikidwa pazidziwitso zapakhomo. Kwa zaka zopitilira khumi, malangizowa asintha kuti awonetse mawonekedwe apadera a odwala aku China, omwe nthawi zambiri amakhala ndi magawo apamwamba kwambiri a matenda komanso matenda oyamba ndi HBV.
Mtundu wa 2026 umaphatikizanso zotsatira zaposachedwa zamaphunziro azachipatala apamwamba kwambiri, kuphatikiza zomwe zidasindikizidwa m'magazini apadziko lonse lapansi ndi akatswiri aku China. Izi zimawonetsetsa kuti malingaliro amankhwala samangotengera ma protocol aku Western koma amakongoletsedwa ndi ma genetic ndi chilengedwe. Malangizowa amalimbikitsa mfundo ya kayendetsedwe ka "multidisciplinary team" (MDT) monga muyezo wa chisamaliro.
Thandizo ladongosolo la khansa ya chiwindi yapamwamba yasintha. Zosintha za 2026 Barcelona Clinic Liver Cancer (BCLC), zomwe zimatanthauziridwa ndi akatswiri otsogola aku China, zimalimbitsa machiritso ophatikizira ma immuno-combination ngati mulingo woyamba wa matenda a Stage C.
Kafukufuku yemwe adachitika koyambirira kwa 2026 akuwonetsa mphamvu ya zosakaniza izi ngakhale mwa odwala omwe ali ndi vuto lachiwindi la Child-Pugh B, gulu lomwe m'mbuyomu linkaganiziridwa kuti ndi losalimba kwambiri kuti lingachiritsidwe mwankhanza. Kukula koyenera kulandira chithandizo uku kumapereka chiyembekezo kwa odwala ambiri.
Kupambana kwakukulu mu hepatology yaku China ndikukhazikitsa njira zochiritsira za neoadjuvant ndikusintha. The Kugwirizana kwa Katswiri waku China pa Neoadjuvant ndi Kutembenuza Therapy kwa Hepatocellular Carcinoma (zosintha za 2024/2026), yofalitsidwa m'magazini apamwamba monga Khansa ya Chiwindi, imapereka njira yosinthira zotupa zosasinthika kukhala zosinthika.
Popeza kuti 70-80% ya odwala aku China amapezeka pazaka zapakatikati kapena zapamwamba pomwe opaleshoni siyingatheke, kutembenuza ndikofunikira. Njirayi imagwiritsa ntchito chithandizo chamankhwala kuti achepetse zotupa, zomwe zimalola kuchiritsa kotsatira. Mgwirizanowu umatanthawuza zomveka bwino za kusankha kwa odwala, maulendo a chithandizo, ndi nthawi ya opaleshoni, kuchepetsa ziwerengero zobwerezabwereza zomwe mbiri yakale zinafikira 70% mkati mwa zaka zisanu pambuyo pa opaleshoni.
Opaleshoni ikadali njira yokhayo yomwe ingachiritse khansa yachiwindi yoyambilira. Komabe, tanthauzo la "resectable" lakula chifukwa cha kuwunika kwabwinoko kusanachitike komanso machiritso owonjezera. Malo otsogola ku China akugwiritsa ntchito matekinoloje otsogola kuti akwaniritse zotsatira zabwino.
Zipatala zazikulu, monga Hepatobiliary and Pancreatic Center ku Beijing Tsinghua Changgung Hospital, amagwiritsa ntchito njira zachipatala zolondola. Madokotala ochita opaleshoni ngati Academician Dong Jiahong amatsogolera magulu omwe amachotsa ziwalo zovuta ndikutaya magazi ochepa komanso nthawi yochira mwachangu.
Kuika chiwindi kumasungidwa kwa odwala omwe akukumana ndi zofunikira (monga Hangzhou Criteria kapena UCSF), zomwe nthawi zina zimakhala zophatikizana kuposa zomwe zimayendera Milan kuti zigwirizane ndi kuchuluka kwa milandu yokhudzana ndi HBV ku China. Kuphatikizika kwa antiviral prophylaxis post-transplant kwachepetsa kwambiri chiwopsezo cha kubwereza kwa omwe ali ndi HBV.
Chithandizo cha radiation chasintha kuchokera ku njira yopumira kupita ku njira yochizira. Kusintha kwa 2026 BCLC momveka bwino kumaphatikizapo Stereotactic Body Radiation Therapy (SBRT) ndi Transarterial Radioembolization (TARE) ngati njira zochizira kwambiri kwa odwala Stage 0/A omwe sakuyenera kuchitidwa opaleshoni kapena kuchotsedwa.
Ofufuza aku China akuchita upainiya "Lattice Radiotherapy" ya zotupa zazikulu zosasinthika (≥10 cm). Njira imeneyi imapereka ma radiation ochuluka kwambiri kumalo enaake mkati mwa chotupacho ndikusunga minofu yathanzi yozungulira. Zambiri zakuchipatala zomwe zidaperekedwa pa Msonkhano Wapachaka wa 2026 wa ASCO zikuwonetsa kulonjeza zachitetezo komanso magwiridwe antchito akaphatikizidwa ndi chithandizo chamankhwala.
Transarterial Chemoembolization (TACE) ikadali mwala wapangodya wa matenda apakati (BCLC B). Komabe, malangizo a 2026 akuchenjeza motsutsana ndi kuphatikiza kwanthawi zonse kwa TACE ndi njira zochizira kunja kwa mayeso azachipatala, ndikuzindikira kuti umboni wapano sugwirizana ndi njira iyi m'magulu onse.
Ma embolic agents atsopano ndi mikanda yotulutsa mankhwala akugwiritsidwa ntchito kuti athandizire kuyankha kwa chotupa. Komanso, lingaliro la "kusamuka kwa siteji ya chithandizo" limalola madokotala kuti azitha kusintha pakati pa TACE, chithandizo chamankhwala, ndi opaleshoni potengera kuyankha kwa chotupacho, kuonetsetsa kuti odwala nthawi zonse amalandira chithandizo choyenera kwambiri.
Kupeza chisamaliro chapamwamba kumafuna kudziwa komwe kuli malo abwino kwambiri. China ili ndi malo angapo apamwamba padziko lonse lapansi a hepatobiliary omwe ali ndi ukadaulo waposachedwa komanso magulu osiyanasiyana.
Chipatala cha Beijing Tsinghua Changgung: Motsogozedwa ndi Academician Dong Jiahong, malowa amadziwika ndi maopaleshoni ovuta a chiwindi komanso kupatsirana ziwalo. Gululi likuphatikizapo akatswiri monga Dr. Lu Qian ndi Dr. Xiang Canhong, omwe amagwira ntchito zochotsa zowonongeka komanso kayendetsedwe kazinthu zambiri. Amapereka zipatala zapadera pamilandu yovuta, kuphatikiza omwe ali ndi vuto la mitsempha.
Chipatala cha Fudan University Zhongshan (Shanghai): Malo opangira kafukufuku wa khansa ya chiwindi ndi ntchito zachipatala. Motsogozedwa ndi akatswiri ngati Pulofesa Gao Qiang, chipatalachi ndichothandiza kwambiri pakukonza zitsogozo zadziko ndikukhazikitsa njira yatsopano yopangira zisankho za CUSE. Ndiwotsogolera pakuphatikiza radiology yothandizira ndi systemic therapy.
Zhongnan Hospital of Wuhan University: Amadziwika ndi kupita patsogolo kwake mu radiotherapy ndi chemoradiotherapy ya zotupa za mafupa ndi zofewa komanso khansa ya hepatobiliary. Zomwe apereka posachedwa ku ASCO zikuwonetsa zatsopano mu lattice radiotherapy ndi maphunziro a metabolic reprogramming.
Zipatala zambiri zapamwamba ku China zimagwiritsa ntchito njira yolumikizirana. Odwala amatha kusungitsa zokambirana kudzera pamaakaunti aboma akuchipatala a WeChat, mapulogalamu odzipatulira, kapena mafoni ochezera. Kwa odwala apadziko lonse lapansi kapena omwe akuchokera kumadera akutali, malo ambiri amapereka ma telemedicine koyambirira kuti awonenso zojambula ndi ma pathological musanapite.
Mtengo wa chithandizo cha khansa ya chiwindi ku China umasiyana kwambiri kutengera siteji ya matendawa, chithandizo chosankhidwa, komanso gawo lachipatala. Komabe, chitetezo champhamvu chadziko lonse chapangitsa kuti chithandizo chamankhwala chikhale chotsika mtengo.
Kuchotsa Opaleshoni: Mtengo wa hepatectomy wokhazikika umachokera ku 40,000 mpaka 80,000 RMB ($5,500 - $11,000 USD). Ma opaleshoni ovuta okhudza kukonzanso mitsempha kapena njira za laparoscopic / robotic zingawononge pakati pa 80,000 ndi 120,000 RMB.
Kuika Chiwindi: Iyi ndiye njira yokwera mtengo kwambiri, kuyambira 400,000 mpaka 600,000 RMB ($55,000 - $83,000 USD). Izi zikuphatikiza opareshoni, ndalama zogulira chiwalo, komanso kugonekedwa kuchipatala koyamba. Chithandizo cha nthawi yayitali cha immunosuppressive chimawonjezera mtengo wopitilira.
Systemic Therapy: Zokambirana zaposachedwa zisanachitike, mankhwala omwe amawaganizira komanso ma immunotherapies anali okwera mtengo kwambiri. Mu 2026, chifukwa chogula zinthu motengera dziko lonse (VBP) komanso kuphatikizidwa mu National Reimbursement Drug List (NRDL), ndalama zatsika kwambiri. Mitengo ya pamwezi ya PD-1 inhibitors ndi TKIs tsopano ikhoza kukhala yotsika ngati 2,000 mpaka 5,000 RMB ($280 - $700 USD) kwa odwala omwe ali ndi inshuwalansi.
China's Basic Medical Insurance (BMI) imakhudza gawo lalikulu la chithandizo cha khansa ya chiwindi. Ndalama zolipirira odwala m'zipatala za boma nthawi zambiri zimapitilira 70% kwa ogwira ntchito akutawuni komanso zocheperako kwa anthu akumidzi, kutengera dera.
Kwa odwala padziko lonse lapansi omwe alibe inshuwaransi, mtengo udzakhala wokwera pamene akulipira mndandanda wathunthu. Komabe, ngakhale pamtengo wathunthu, chithandizo ku China nthawi zambiri chimakhala chotsika mtengo poyerekeza ndi US kapena Europe, popanda kusokoneza chisamaliro chabwino kapena kupeza mankhwala aposachedwa.
Kusankha chithandizo choyenera kumadalira siteji ya chotupa, ntchito ya chiwindi, ndi momwe wodwalayo alili. Gome lotsatirali likufanizira njira zoyambira zomwe zikupezeka ku China mu 2026.
| Chithandizo cha Makhalidwe | Makhalidwe Ofunikira | Njira Yabwino Yogwiritsira Ntchito |
|---|---|---|
| Kuchotsa Opaleshoni | Cholinga chochizira; golide muyezo kwa siteji oyambirira; zimafuna kusungirako chiwindi chokwanira. | Chotupa chimodzi kapena matenda ochepa a multifocal; Child-Pugh A chiwindi ntchito; palibe vuto lalikulu la mitsempha. |
| Kuika Chiwindi | Kuchiritsa; amachiza chotupa ndi matenda enaake; kuchepetsedwa ndi kupezeka kwa opereka. | HCC yoyambirira mkati mwa Milan / Hangzhou njira; decompensated cirrhosis; osayenera kuchotsedwa. |
| Ablation (RFA/MWA) | Zowonongeka pang'ono; kufananizidwa ndi opaleshoni ya zotupa zazing'ono; mtengo wotsika. | Zotupa <3cm; odwala osayenera opaleshoni; mlatho kumuika. |
| TACE | Kuwongolera kwapakati; kuchepetsa kapena kuchepetsa; zobwerezedwa. | Multifocal matenda popanda kufalikira kwa extrahepatic; BCLC Gawo B; kusungidwa kwa chiwindi ntchito. |
| Immuno-Targeted Therapy | Kuwongolera mwadongosolo; kumawonjezera kupulumuka mu magawo apamwamba; zotsatira zoyipa. | HCC yosasinthika; kuwonongeka kwa mitsempha; extrahepatic metastasis (BCLC Gawo C); Mzere woyamba wamba. |
| Radiotherapy (SBRT) | Zosasokoneza; mwatsatanetsatane kwambiri; zikuwonekera ngati zochizira milandu yosankhidwa. | Zotupa pafupi ndi ziwiya zazikulu zomwe kutulutsa kumakhala kowopsa; portal mtsempha thrombosis; oligometastasis. |
Kupita patsogolo kodziwika mu 2026 ndikukhazikitsidwa kwa dongosolo la CUSE popanga zisankho zachipatala. Zoperekedwa m'mawu osinthidwa a BCLC komanso otsogozedwa ndi akatswiri aku China, chitsanzochi chimapitilira njira zokhazikika kupita kumayendedwe okhazikika odwala.
Ndondomeko ya CUSE ikuwunika magawo anayi ofunikira kuti atsogolere gulu la Multidisciplinary Team (MDT):
Ndondomekoyi imatsimikizira kuti ndondomeko zachipatala sizimangokhalira kuwerengera bwino komanso zimakhala zotheka komanso zovomerezeka kwa wodwala aliyense. Ndizothandiza makamaka pamilandu yam'malire pomwe njira zambiri zothandizira zilipo, zomwe zimathandiza kuyendetsa malonda pakati pa nkhanza ndi moyo wabwino.
Mabungwe ofufuza aku China akuthandizira kwambiri kumvetsetsa kwapadziko lonse lapansi za khansa ya chiwindi. Maphunziro aposachedwa omwe aperekedwa pamisonkhano yayikulu ngati ASCO 2026 akuwonetsa njira zingapo zodalirika.
Ofufuza akuwulula momwe kusintha kwa metabolic kumathandizira kukula kwa khansa. Kafukufuku wochokera ku chipatala cha Wuhan Zhongnan adawonetsa kuti metabolites ngati alpha-ketoglutarate imatha kuyambitsa ferroptosis (imfa yodalira chitsulo), kukulitsa chidwi cha khansa ya colorectal ndi chiwindi ku radiation. Izi zimatsegula zitseko za machiritso ophatikiza omwe amawongolera kagayidwe kachotupa kuti apititse patsogolo mphamvu zamankhwala azikhalidwe.
Innovative immunotherapies ikukula. Mayesero azachipatala akufufuza ma virus a oncolytic (monga OH2) omwe amaperekedwa mwachindunji muzotupa, ndikutsatiridwa ndi chitetezo chamthupi chotchinga. Deta yoyambirira ikuwonetsa kuti njira yotsatizanayi imatha kulimbikitsa chitetezo chamthupi cholimbana ndi chotupa, ngakhale m'matumbo "ozizira" omwe nthawi zambiri samayankha ku immunotherapy kokha.
Ngakhale HCC ndiye cholinga chachikulu, kukwera kwa khansa yapakatikati (CRC) ku China kwabweretsa chidwi ku Colorectal Liver Metastases (CRLM). Ndi CRC kukhala khansa yachiwiri yodziwika bwino ku China, njira zapadera za CRLM ndizofunikira. Chithandizo chamankhwala cham'deralo komanso kasamalidwe kokwanira zikuwonetsa kukulitsa moyo kwa odwalawa, pomwe zolembera zikuwonetsa kuti chiwindi ndi malo omwe amapezeka kwambiri a CRC.
Inde, khansa ya m'chiwindi yoyambilira imatha kuchiritsidwa kudzera mu opaleshoni, kuika chiwindi, kapena kuchotsa. Kwa magawo apamwamba, pamene "mankhwala" sakhala ofala kwambiri, cholinga chake ndi kulamulira kwa nthawi yaitali komanso kupulumuka. Kubwera kwamankhwala othandiza a immuno-combination kwasintha HCC yapamwamba kukhala matenda osachiritsika kwa odwala ambiri, okhala ndi kupulumuka kwakukulu kwapakatikati poyerekeza ndi zaka zam'mbuyomu.
Mitengo imasiyana mosiyanasiyana. Opaleshoni yoyambira ikhoza kuwononga $ 6,000 USD, pamene zoikamo zovuta zimatha kupitirira $ 80,000 USD. Komabe, kwa nzika zaku China zomwe zili ndi inshuwaransi, ndalama zotuluka m'thumba ndizotsika kwambiri chifukwa cha mfundo zobweza. Mankhwala apamwamba monga PD-1 inhibitors tsopano ndi otsika mtengo, amawononga madola mazana angapo pamwezi pambuyo pa inshuwalansi, zomwe zimapangitsa kuti chithandizo chapadziko lonse chipezeke.
Choyambitsa chachikulu ndi matenda a Hepatitis B, omwe nthawi zambiri amakhala. Zifukwa zina zazikulu ndi Hepatitis C, kumwa mowa mopitirira muyeso, komanso mochulukirachulukira, matenda osamwa mowa amafuta a chiwindi (NAFLD) oyendetsedwa ndi kunenepa kwambiri komanso shuga. Kuwonekera kwa Aflatoxin kumakhalabe pachiwopsezo kumadera ena.
Mwamtheradi. Zipatala zazikulu monga Beijing Tsinghua Changgung Hospital ndi Fudan Zhongshan Hospital zili ndi madipatimenti apadziko lonse lapansi othandizira odwala akunja. Amapereka ogwirizanitsa olankhula Chingelezi, thandizo la visa, ndi ndondomeko zochiritsira zoyenera. Ngakhale chithandizo cha inshuwaransi chingakhale chosiyana, ubwino wa chisamaliro umagwirizana ndi miyezo yapadziko lonse, nthawi zambiri pamtengo wotsika mtengo kusiyana ndi mayiko a Kumadzulo.
Kumvetsetsa zimayambitsa khansa ya chiwindi ndi sitepe yoyamba yopewera ndi kuzindikiridwa msanga, makamaka m'madera omwe ali pachiwopsezo chachikulu monga China komwe Hepatitis B imapezeka. Mu 2026, mawonekedwe a chithandizo cha khansa ya chiwindi ku China amadziwika ndi luso lachangu, zosintha zotsogola, komanso kudzipereka kwamphamvu pakupanga njira zochiritsira zapamwamba. Kuchokera pakufalikira kwa ma immuno-combination regimens mpaka kukonzanso njira zopangira opaleshoni komanso kukhazikitsa zigamulo zoyang'anira odwala monga CUSE, China ikukhazikitsa njira zatsopano zothandizira hepatobiliary.
Odwala masiku ano ali ndi zosankha zambiri kuposa kale. Kaya kudzera mu opaleshoni yochizira, yolondola ya radiotherapy, kapena njira zochiritsira zowonjezera moyo, kuphatikizika kwa ukatswiri wosiyanasiyana kumatsimikizira kuti wodwala aliyense amalandira dongosolo loyenera. Ndi chithandizo cha ndondomeko za inshuwalansi za dziko kuchepetsa zolepheretsa zachuma, njira yochokera ku matenda kupita ku moyo ndi yomveka komanso yowonjezereka. Kwa aliyense amene akufuna chithandizo, malo apamwamba padziko lonse lapansi komanso magulu a akatswiri ku China amapereka chiyembekezo, kuphatikiza sayansi yamakono ndi chisamaliro chachifundo kuthana ndi matendawa.