Pholoso e laoloang ea lithethefatsi: Tataiso e felletseng 

Ho tsamaisoa ha lithethefatsi tse laoloang Litsamaiso li etselitsoe ho lokolla meriana ka nako e telele, ho fana ka melemo e mengata ho feta mekhoa e tloaelehileng ea ho tsamaisa lithethefatsi. Litsamaiso tsena li boloka mearong ea lithethefatsi e le ka har'a mofuta oa kalafo ka har'a mofuta oa kalafo le ho ntlafatsa mahlale a moea. Sengoliloeng sena se fetela melao-motheong, mefuta, mefuta, le melemo le lits'ebetso tsa Ho tsamaisoa ha lithethefatsi tse laoloang, o fana ka kutloisiso e qaqileng ea tšimo ena e sa sebetseng.

TLHOKOMELISO E FIHLETSOENG

Ho lokolloa ke eng?

Kholiso e laoloang e bua ka mokhoa oa ho fana ka sethethefatsi sethaleng se reriloeng esale pele le sebaka se hlophisitsoeng. Ho fapana le liforomo tsa ho lokolla kapele, tse lokollang tekanyetso eohle kapele, Ho tsamaisoa ha lithethefatsi tse laoloang Litsamaiso li eketsa tokollo ea meriana ka lihora tse ngata, matsatsi, kapa likhoeli likhoeling. Mokhoa ona o fana ka tšusumetso e matla haholoanyane mme e fokotsa khafetsa ea ho dosing.

Melaoana ea tokollo e laoloang

Melao-motheo e mengata e tataisa boqapi le ts'ebetso ea Kholiso e laoloang Litsamaiso:

• Phapang: Ho lokolloa ha lithethefatsi tse laoloang ke sekhahla seo moriana o o itširetseng ka bongata matrix ea polymer.
• Qhala taba: Thula ea lithethefatsi e laoloang ke sekhahla seo motho ea polymet matrix a qhibilihang kapa arodes.
• Osmosis: Ho lokolloa ha lithethefatsi ka mathata a li-osmotic li fapanyetsana liphapang ho feta ka mose ho membrane e emeng e loketseng.
• Khoholeho: Ho lokolloa ha lithethefatsi ho hlahisitsoeng butle ka mokhoa o khabisitsoeng ka mochini oa polymer matrix.

Mefuta ea lits'ebetso tse laoloang

Litsamaiso tsa Matrix

Sistimi ea matrix e hloka ho kenyelletsa sethethefatsi ka har'a polymer matrix. Setlhare se lokollotsoe ka e 'ngoe ke li-affusion ka matrix kapa ka khoholeho ea matrix ka boeona. Litsamaiso tsena li bonolo haholo ho iketsetsa ebile li ka tsamaisana le ho fana ka profime e fapaneng ea ho lokolloa.

Litsamaiso tsa Reservoir

Mekhoa ea polokelo e nang le mantlha e nang le moriti o nang le moriana o pota-potiloeng ke membrane ea polymer. Setlhare se lokollotsoe ka har'a membrane ka sekhahla se laoloang. Litsamaiso tsena li fana ka taolo ea precise ho feta ho lokolloa ha lithethefatsi empa ho ka ba thata haholo ho etsa tlhahiso.

Litsamaiso tsa Osmotic

Tsamaiso ea osmotic e sebelisa khatello ea lefu la ho laola ho lokolloa ha lithethefatsi. Setlhare se na le memmbrane e loketseng seliba se nang le seliba se nang le seliba se nang le seliko, 'me metsi a huloa tsamaisong ea osmosisi. Sena se theha khatello e sutumetsang sethethefatsi se tsoang ho lesoba le lenyane. Tsamaiso ea Osmotic e fana ka phetiso e hlakileng le e sa fetoheng.

Litsamaiso tsa Li-Arodible

Litsamaiso tse fetolang li sebelisa polymers tse nyenyefatsang kapa tse litšila ka mor'a nako, ho lokolla sethunya ha mothese o senyeha. Litsamaiso tsena hangata li sebelisoa bakeng sa phano ea lithethefatsi tse telele.

Melemo ea tokollo e laoloang

Ho ntlafatsoa ho ntlafalitsoeng

Khafetsa re nosetsa khafetsa u ntlafatsa ho latela melao ea meriana, haholo-holo bakeng sa maemo a sa foleng.

Litlamorao tse fokotsehileng

Ho boloka litlhare tse sebelisang litlhare ka har'a fensetere ea kalafo e fokotsang khatello e ka ba lebisang liphellong tse mpe.

Ntlafatsa ts'ebetso ea kalafo

Maemo a lithethefatsi a feto-fetong a ntlafatsa litšoaneleho tsa kalafo le ho thibela linako tsa meaho ea lithethefatsi tse tlase kapa tse nang le chefo.

Tsamaiso ea Lithethefatsi

Tse ling Kholiso e laoloang Litsamaiso li ka rereloa ho isa lithethefatsi ka kotloloho ho lisele tse itseng kapa litho, ho eketsa katleho le ho fokotsa mokhoa o hlakileng oa ho pepesetsoa. Nahana ka lipatlisiso tse sa feleng ho litsi tse kang Shandong Baofa, e shebileng phekolo ea phekolo ea mafu a fapaneng.

Likopo tsa tokollo e laoloang

Mafu a pelo

Kholiso e laoloang Lihlooho li sebelisoa ho fana ka meriana bakeng sa khatello ea meriana, Angina le maemo a mang a pelo, a hlakisa kotsi ea litlhaselo tsa pelo le lichabeng.

Lefu la tsoekere

Insulin le meriana e meng ea lefu la tsoekere hangata e tsamaisoa ho sebelisoa Kholiso e laoloang Litsamaiso tsa ho boloka maemo a Glycese a le tsitsipano mme a ntlafatsa taolo ea Glycemic.

Tsamaiso ea bohloko

Kholiso e laoloang Opioid le analgesics le analgesics ba fana ka liphallelo ba bohloko, ba tsamaisang tlhoko ea ho jatsa khafetsa le ho fokotsa kotsi ea ho lemalla.

Kalafo ea kankere

Kholiso e laoloang Lithethefatsi Liete tsa litlhare li ka lokisa lisele tsa mofets'e, li fokotsa ts'enyehelo ea lisele tse phetseng hantle le litlamorao. Shandong Baofa e kenella ka mafolofolo ho etsa lipatlisiso mabapi le ts'ebeliso ea tokollo e laoloang ho kalafo ea kankere.

Likopo Tse Ling

Kholiso e laoloang e boetse e sebelisoa maemong a fapaneng a likopo tse ling, ho kenyelletsa:

• Phekolo ea ho fetola li-hormone
• Phekolo ea mafu a methapo ea kutlo
• Ente
• Meriana ea liphoofolo

Mehlala ea Lihlahisoa tsa Khatiso e Phahameng

Litlhare tsa molomo

Meraba e mengata ea molomo e fumaneha ho Kholiso e laoloang liforomo, ho kenyelletsa:

• Metformin e atolositsoeng ea lefu la tsoekere
• Nifdipine e atolositsoeng ea ho lokolloa ha hypertension
• OxccoDone e atolositsoeng ea taolo ea bohloko

Litefiso tsa Transdermal

Transdermal matloana a fana ka lithethefatsi ka lebelo le laoloang. Mehlala e akaretsang:

• Li-actico tsa Nicotine bakeng sa ho tsuba
• Fentanyl likoti tsa taolo ea bohloko
• Lipapali tsa hotele Lipapali

Inclants

Li-inclant li bolokiloe lisebelisoa tse kentsoeng li fetisa lithethefatsi ka nako e telele. Mehlala e akaretsang:

• Likonteraka tsa ho kenella
• Lithunya tsa lithethefatsi

Liphephetso le Litaelo tsa Bokamoso

Liphephetso

Le ha ho na melemo e mengata ea Kholiso e laoloang, mathata a mangata a sala a tsoa:

• Ho Rarahana
• Litšenyehelo
• Ho fapana ha lithethefatsi
• Mabaka a Ikhethileng a Bokuli

Mahlakore a ka moso

Patlisiso ea Bokamoso ho Ho tsamaisoa ha lithethefatsi tse laoloang e shebaneng le:

• Ho nts'etsapele litsamaiso tsa phepelo ea lithethefatsi tse ngata le tse lebisitsoeng
• Sebelisa lisebelisoa tsa biodegradadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadadad
• Ho tsamaisa lithethefatsi ho ipapisitse le litlhoko tsa motho ka mong
• Ho kopanya Nanotechnology le Microfluids

Sephetho

Ho tsamaisoa ha lithethefatsi tse laoloang e emela tsoelo-pele ea bohlokoa ho theknoloji ea pharma, e fana ka melemo e mengata ho mekhoa ea ho tsamaisa lithethefatsi e tloaelehileng. Joalokaha lipatlisiso li ntse li tsoela pele le mahlale a macha a theknoloji, Kholiso e laoloang Litsamaiso li ikemiselitse ho bapala karolo ea bohlokoa ea ho ntlafatsa liphetho tsa motsoamong le tsa bophelo bo botle ba ho holisa tlhokomelo.

Lintlha le lisebelisoa

Mona ke mohlala oa kamoo mekhoa ea ho tsamaisa lithethefatsi e ka etsoang ho latela maemo a ho lokolloa. Ka kopo hlokomela hore ena ke sesupo se nolofatsang bakeng sa merero e kenyelelitsoeng ho li-paristente ea sebele, 'me ho na le mekhoa ea' mele ea 'nete e tla fapana ho latela sethethefatsi se ikhethang, se nang le mamello.

* Tlhokomeliso: Lintlha lia bontša litekanyetso le tsa 'nete li tla fapana.

Dislaimer: Sengoliloeng sena ke sa merero ea leseli 'me se sa bolele keletso ea bongaka. Ithuta ka setsebi sa bophelo bo botle bakeng sa mathata a bophelo bo botle kapa pele a etsa liqeto tse amanang le kalafo ea hau.