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Therapy ea Depot ea ho Lokolla butle
Ultra Minimum Incision Personalized Intra-Tumoral Chemo-Immuno Therapy
Motsoako oa motsoako o khahlanong le mofetše o entsoeng ka motsoako oa mokhoa o tsitsitseng oa ho lokolloa, lithethefatsi tsa chemotherapy (lithethefatsi tse peli), le motsoako oa 'mele oa ho itšireletsa mafung o kenngoa ka ho toba ka har'a hlahala' me o kenngoa ka har'a hlahala tlas'a tataiso ea CT, ultrasound, kapa endoscopy. Lithethefatsi tse khahlanong le kankere li lokolloa butle-butle nakong ea matsatsi a 7-20, li bolaea lisele tsa kankere, li qoba litla-morao tse chefo tsa lithethefatsi 'meleng oohle le ho finyella sepheo sa ho felisa hlahala; The self tumor antigens e lokollotsoeng ke lisele tsa mofetše tse bolailoeng ke lithethefatsi tse kopantsoeng ka nako e le 'ngoe, ka thuso ea li-adjuvants tsa' mele oa ho itšireletsa mafung, li kenya tšebetsong karabelo ea 'mele ea ho itšireletsa mafung, ka hona, e bapala karolo ea ho hlakola lisele tsa mofetše tse iphetang kapa tsa metastatic. Ka ho toba 'meleng targeted targeted targeted polao le the decapitation therapy e ka etsoa bakeng sa lihlahala tse kotsi le liso tsa metastatic likarolong tse sa tšoaneng tsa' mele, tse loketseng lihlahala tse tiileng tsa pele, tse bohareng le tsa morao likarolong tsohle tsa 'mele. Kalafo ena e fumane mahlale a nang le tokelo ea molao China, United States le Australia. Ho tloha ha e sebelisoa ka 1998, e alafa bakuli ba mofetše ba fetang 80000 mme e fumane litholoana tse ntle tsa kalafo!
Tlatsetso ea rona e kholo ke hore phekolo ea nako e telele ea ho lokolloa e kopanya melemo ea chemotherapy le immunotherapy, 'me ka lekhetlo la pele, tse peli li kopantsoe le ho sebelisoa ho phekolo ea intratumoral ka ho kenella. E kopanya kalafo ea lehae le ea lefats'e, 'me e eketsa khatello ea maikutlo le nako ea ts'ebetso ea lithethefatsi ka ho lokolloa ha lithethefatsi ka har'a hlahala, e sa bapaleng feela phello ea anticancer ea lehae ea lithethefatsi tsa chemotherapy, empa hape e ela hloko karolo ea systemic immunotherapy, ka hona e etsa mefokolo ea liphekolo tse ling, e fana ka mehopolo le mekhoa e mecha ea kalafo ea mofets'e, haholo-holo bakeng sa lihlahala tse bohareng le tse tsoetseng pele, haholoholo bakeng sa ho fokotsa boleng ba ho fetisoa ha hlahala. Phekolo ea UMPIC e na le molemo oa ho sebelisa hlahala joalo ka mohloli oa antigen le ente ea autologous, e leng hape e tsamaellanang le mokhoa oa nts'etsopele oa Moriana oa Motho. 'Me e sebelisoa tleliniking, hapten e kopantsoe le lithethefatsi tsa chemotherapy bakeng sa phekolo e tsoelang pele ea phekolo ea kankere ea pancreatic, ha e ntse e etsa hore ho be le phello ea distal, eo mohloli oa eona e leng ho susumetsa karabelo ea 'mele ea ho itšireletsa mafung, lisele tsa T-cell tse amanang le CD4, CD8, DC, T le NK tse amanang le B-cell tse amanang le tumor autoantibodies: Antibodies ho P53, P16, Cmyc2MP, HCC le li-oncogenes tse ling, lena ke lekhetlo la pele ho fumana hore T le B li ameha karabelo ea 'mele ea ho itšireletsa mafung,' me mesebetsi ea kliniki ea phello ea distal le phekolo ena e ile ea khethoa bakeng sa "Litaelo tsa Ts'ebetso ea Kliniki bakeng sa Phekolo ea Ts'ebetso ea Kankere e Phahameng ea Pancreatic" (Trial) (khatiso ea 7) e kopantsoeng ke Mokhatlo oa Chaena oa Anti-Cancer, National Clinical Medical Research Center e phatlalalitsoeng ke Mokhatlo oa Sechaba oa Lipatlisiso le Bongaka ba Sechaba.
Journal of Clinical Radiology, volume 43, nomoro ea 19, 2024, 1636-1648.
Dr.Baofa Yu le sehlopha sa hae lipatlisiso tsa mantlha tse amanang le litabatabelo li kenyelelitsoe tse latelang:
1.Remote lihlahala tse nyenyane li ka laoloa, ka bopaki le lihlooho;
2.Ho tsepamisa maikutlo ho subclinical ho ka laoloa, kahoo nako ea ho phela ea bakuli e telele;
3.E boetse e fokotsa ho potoloha lisele tsa hlahala (CTC) ka 80%, sehlooho se lokelang ho hatisoa;
4.E ka susumetsa hypothalamus ea boko ho kenya letsoho karabelong ea 'mele ea ho itšireletsa mafung,' me ka nako e ts'oanang, e ka boela ea boloka thabo ea boko ka 'mino ho hokahanya khahlanong le kankere. Sengoliloeng se phethiloe, 'me moprofesa oa UCSD o fana ka maikutlo a ho se romella ho tsa tlhaho kapa meriana ea tlhaho.
UMIPIC-Therapy: Sebopeho sa motsoako oa lithethefatsi
Adjuvant: ho eketsa karabelo ea 'mele ea ho itšireletsa mafung le e tobileng
Sustaining agent/ Ketso ya ho tshehetsa: ho tshoara tsohle maemong a hodimo nako e telele
Liemeli tsa Antitumor: Mekhatlo e lumelletsoeng ke FDA e bakile lefu la hlahala ho ntša li-antigen hore li se ke tsa hoama.
Melemo e tšeletseng e meholo ea Slow Release Depot Therapy: ho lebisa tlhokomelo e fokolang, ho theola tumor, ho thibela 'mele oa ho itšireletsa mafung, liente tse ngata, tse tšoarellang nako e telele, tse sireletsehileng le tse sebetsang.
Melemo ea makhasi a mangata a hlahala
(1) Tumoricidal Thibelo sebakeng sa mantlha sa hlahala: tlas'a tataiso ea CT kapa ultrasound, ho itšetlehile ka boholo ba hlahala, o ka enta tekanyo e loketseng ea motsoako oa motsoako.
(2) Ho ts'ehetsa lithethefatsi tsa anticancer: oxidant induced coagulation ka har'a hlahala ho ts'oara sethethefatsi ka nako e telele le ho fihlela katleho e ntle.
(3) Thibelo ea 'mele ea ho itšireletsa mafung: ho tlosa hlahala e kholo ka nako eo ho susumetsa karabelo ea immunology ho laola lesion e nyenyane ea hlahala sebakeng sa bobeli sa hlahala.
4
(5) Ho bonolo ho e sebelisa : E ka phekola hlahala ea mantlha le eona e ka phekola hlahala ea bobeli mme e ka etsa hore motho a khannele immunotherapy.
(6) E bolokehile ebile e sebetsa.
