Unikezelo lweziyobisi lweNdawo olushibhile loMhlaza

Unikezelo lweziyobisi olushibhile lwasekhaya lweCancer Eli nqaku liphonononga iindlela ezintsha zokuhanjiswa kweziyobisi okunexabiso elisebenzayo kunye nokujoliswe kuko kunyango lomhlaza, kugxilwe kunyango lwasekhaya olunciphisa iziphumo ebezingalindelekanga zenkqubo. Sihlola iindlela ezahlukeneyo, izinto eziluncedo kunye nezingeloncedo kuzo, kunye nezalathiso zekamva kuphando.

Unikezelo lweziyobisi lweNdawo olushibhile loMhlaza: Isishwankathelo esiBanzi

Unyango lomhlaza lubiza imali eninzi, kwaye unyango lwenkqubo ludla ngokuza neziphumo ebezingalindelekanga ezityhafisayo. Ukufuna unyango olungabizi kakhulu nolusebenzayo ngakumbi lomhlaza lukhokelele kwinkqubela phambili ebonakalayo ekuhanjisweni kwamachiza endaweni. Le ndlela ijolise ekugxininiseni amayeza ngokuthe ngqo kwindawo ye-tumor, ukunciphisa ukuvezwa kwezicubu eziphilileyo kunye nokunciphisa iindleko ezipheleleyo zonyango ngokufuna iidosi eziphantsi. Eli nqaku liza kuphonononga iindlela ezahlukeneyo zokuphumelela ukuhanjiswa kweyeza elishibhile kwingingqi yomhlaza, ukuphonononga ukusebenza kwazo, ukusikelwa umda, kunye namandla ophuhliso lwexesha elizayo. Siza kuqwalasela indima ebalulekileyo yamaziko ophando afana ne IZiko loPhando ngoMhlaza laseShandong Baofa ekuqhubeleni phambili lo mmandla.

Iindlela zokuhanjiswa kweziyobisi endaweni

I-Nanoparticles ekujoliswe kuyo

Iinanoparticles zenziwa ukuba zithwale ii-arhente zonyango ngokuthe ngqo kwiiseli zethumba. Ubungakanani babo obuncinci bubavumela ukuba bangene kwizicubu kwaye baqokelele ngaphakathi kwamathumba. Olu nikezelo lujoliswe kuko lunciphisa idosi yechiza elifunekayo, okunokubanakho ukuthoba iindleko zonyango zizonke. Iindidi ezahlukeneyo ze-nanoparticles, ezibandakanya i-liposomes, i-polymeric nanoparticles, kunye ne-inorganic nanoparticles, ziyaphononongwa. Iimpawu ezithile, ezifana nokuguqulwa komphezulu wokunikezelwa okujoliswe kuyo kunye nokunciphisa i-biodegradability ukwenzela ukukhutshwa okukhuselekileyo, igalelo ekusebenzeni kakuhle kunye neendleko ezisebenzayo zale ndlela. Ukuphuhliswa kwe-nanoparticles ye-biodegradable yinkalo ephambili yophando ejolise ekunciphiseni iindleko zexesha elide kunye nomngcipheko ohambelana nokuqokelela kweziyobisi emzimbeni.

IiPatches zeMicroneedle

Iipetshi ze-Microneedle zibonelela ngendlela engenabuhlungu kunye nencinci yokuhlasela amayeza. Ezi naliti zincinci zingena esikhumbeni, zihambisa iyeza ngokuthe ngqo kwidermis okanye kwi-subcutaneous tissue. Kunyango lomhlaza wasekhaya, iipetshi ze-microneedle ezilayishwe nge-chemotherapeutic agents okanye i-immunotherapies ziyaphandwa, ngakumbi zomhlaza wolusu. Le ndlela inokunciphisa kakhulu iindleko ezinxulumene nolawulo, ukulaliswa esibhedlele, kunye neengxaki ezinokubakho zeendlela zokutofa zendabuko. Uphando olongezelelweyo lujolise ekuphuculeni ubunzulu bokungena kunye nokulawula ukukhutshwa kwechiza kula mabala.

I-Ultrasound egxininisiweyo

I-ultrasound egxininisiweyo isebenzisa amaza aphezulu e-ultrasound ukuze ikwazi ukungena kwi-membrane yeseli, ivumela ukuhanjiswa okuphuculweyo kwamachiza kwiithishu ekujoliswe kuzo. Idityaniswe nee-microbubbles, obu buchule, bubizwa ngokuba yi-sonoporation, buququzelela ukungena kwii-agent zonyango ngokuthe ngqo kwiiseli zomhlaza, ukuphucula ukusebenza konyango kunye nokunciphisa iimfuno zedosi, kunegalelo ngakumbi. ukuhanjiswa kweyeza elishibhile kwingingqi yomhlaza. Ngelixa izixhobo ezibizayo zifuneka, amandla ayo okunciphisa ubutyhefu benkqubo kunye nokunciphisa imfuno yeedosi eziphezulu kuyenza ibe yindawo exabisekileyo yophando lonyango lomhlaza oluneendleko ezisebenzayo.

Ukuqwalaselwa kweendleko kunye nemingeni

Ngelixa iindlela zonikezelo zasekhaya zinesithembiso sokuncitshiswa kweendleko, imingeni emininzi isekhona. Ukuphuhliswa kunye nokuveliswa kwee-nanoparticles ezijoliswe kuzo kunye ne-microneedles zingabiza. Ngaphaya koko, ukuguqulelwa kweklinikhi kobu buchwepheshe kufuna uvavanyo olungqongqo kunye nolwamkelo lolawulo, okongeza kwindleko iyonke. Nangona kunjalo, ukugcinwa kwexesha elide elinokubakho ekunciphiseni ukulaliswa esibhedlele, imiphumo embalwa yenkqubo yenkqubo, kunye neziphumo zonyango eziphuculweyo zinokugqithisa utyalo-mali lokuqala. Uhlalutyo olubanzi lweendleko-benefit lubalulekile ekumiseleni ukuqina koqoqosho kukonke okwahlukileyo ukuhanjiswa kweyeza elishibhile kwingingqi yomhlaza iindlela.

Izalathiso zexesha elizayo

Uphando lwexesha elizayo luya kugxila ekwandiseni iindlela ezikhoyo kunye nokuphuhlisa izicwangciso ezintsha ze ukuhanjiswa kweyeza elishibhile kwingingqi yomhlaza. Oku kubandakanya ukuphuculwa kobuchule bokujolisa, ukuphuhlisa imathiriyeli enokubola, kunye nokudibanisa ubuchule bokucinga obuphambili bokuhanjiswa kwechiza oluchanekileyo. Intsebenziswano phakathi kwabaphandi, oogqirha, kunye neenkampani ezixuba amayeza ibalulekile ukukhawulezisa ukuguqulelwa kwezi nkqubela phambili zibe kunyango lomhlaza olufikelelekayo nolusebenzayo. I IZiko loPhando ngoMhlaza laseShandong Baofa, ngokugxininisa kuphando kunye nokuveliswa kwezinto ezintsha, idlala indima ebalulekileyo kulo mzamo uqhubekayo.

Uthelekiso lweNdlela zokuHanjiswa kweZiyobisi zeNdawo

I-Disclaimer: Le ngcaciso yenzelwe iinjongo zemfundo kuphela kwaye akufanele ithathwe njengengcebiso yezonyango. Soloko udibana nengcali yokhathalelo lwempilo kuyo nayiphi na inkxalabo yezempilo okanye ngaphambi kokuba wenze naziphi na izigqibo ezinxulumene nempilo okanye unyango lwakho.