ISibhedlele soMhlaza saseTshayina siqesha owawongwa ngewonga leNobel uNjingalwazi uCraigC.Melloas onguSonzululwazi oyiNtloko 

NgoJuni 8-9, uNjingalwazi Craig Melo, owathweswa imbasa yeNobel kwiPhysiology okanye Medicine, kunye noNjingalwazi Jiang Wei ovela kwiCancer Hospital yeChinese Academy of Medical Sciences bandwendwela iDongping, eShandong kwaye bathatha inxaxheba kwi “Nobel Medical Prize Oncology Academic Exchange Conference” ebisingathwe yiTaimei Baofa Cancer Hospital ngokutshintshiselana ngokunzulu kwezemfundo. Olu hambo luphawula indibaniselwano enkulu yokuphumelela iBhaso leNobel kwitekhnoloji yophazamiseko ye-RNA kunye nesibhedlele “sonyango olukhutshwa kancinci lwethala leencwadi”, lufaka umfutho oqinileyo kwicandelo lokunyanga umhlaza wehlabathi, ngakumbi unyango lomhlaza wepancreatic.

Kwi-2016, uProfesa Merleau wancoma kakhulu uNjingalwazi Yu Baofa, umlawuli weSibhedlele soMhlaza saseTaimei Baofa, ngokuqulunqa i-"UMIPIC" kwi-"Third Nobel Laureate Medical Summit". Emva kweminyaka elithoba, le ncoko yababini evela kumaqonga aphezulu emfundo yamazwe ngamazwe iya kuqhubeka nokubhala isahluko esitsha eDongping, eShandong. Utyelelo lukaNjingalwazi uMeiluo aluyoncoko enzulu kuphela phakathi kweengqikelelo zenzululwazi zamazwe ngamazwe kunye nokuveliswa kwezinto ezintsha eTshayina, kodwa kwakhona yibhulorho entsha yentsebenziswano kuphando lwethumba phakathi kweTshayina namazwe angaphandle.

Kwintlanganiso yotshintshiselwano, uNjingalwazi Melo wabelane ngeembono zakhe zamva nje kwicandelo lokuphazamiseka kwe-RNA kunye nophando lwethumba. Unjingalwazi uJiang Wei ovela kwiSibhedlele soMhlaza weZiko laseTshayina leSayensi yezoNyango ekwabelwana ngalo 《UbuGcisa boPhando loMhlaza: Usetyenziso lweRNAi, iMifuziselo yeZilwanyana kunye neSigqibo esiPhetheyo》.Isazi semfundo ephakamileyo uYu Baofa wabelane ngophando lweklinikhi kwi-self nano eyenzelwe i-tumor immunotherapy yamathumba aqinileyo kwintlanganiso yotshintshiselwano, kwaye kwabelwana ngeminyaka engama-27 yamava ezonyango ekusebenziseni unyango oluzinzileyo lomhlaza. Phambi kokuba kuqale intlanganiso yotshintshiselwano, uNjingalwazi uMerleau kunye noNjingalwazi uYu Baofa bafikelele kwisivumelwano sentsebenziswano yophando lomhlaza kwaye bavuma ngovuyo ukuqeshwa kweNzululwazi eyiNtloko ye-Baofa Medical. Unjingalwazi uYu Baofa wenze isipho kuNjingalwazi uMerleau – umzobo weoli we-Merleau osayinwe nguNjingalwazi uYu Baofa. Indibaniselwano egqibeleleyo yetekhnoloji yophazamiseko ye-RNA eyawongwa ngembasa kaNobel kunye netekhnoloji enelungelo elilodwa lomenzi kaNjingalwazi uYu Baofa "ithala leencwadi elikhutshwa ngokuzinzileyo" yeyona ntsikelelo inkulu kwizigulana ezinomhlaza. Olu tshintshiselwano luya kuba liqonga lokuqokelela ubulumko behlabathi kunye nokungqubana kweentlantsi ezintsha, kwaye imbono yalo yesayensi ekwinqanaba eliphezulu kulindeleke ukuba ibonise umkhombandlela wokuphumelela kuluntu lwe-oncology yasekhaya.

Ukusukela ekusekweni kwayo kwiminyaka engama-27 eyadlulayo, iSibhedlele soMhlaza saseTaimei Baofa sizuze iziphumo ezibalulekileyo ekusebenziseni i-“UMIPIC” yechemotherapy kunye ne-immunotherapy ngaphakathi kwamathumba, ngakumbi umhlaza wepancreatic. Ibandakanyiwe "kwiZikhokelo zokuSebenza kweKlinikhi yoNyango loNyango oluPhezulu lwePancreatic Cancer" (Uvavanyo) (uHlelo lweSixhenxe). Nangona kunjalo, kusekho iiyantlukwano zomntu ngamnye ekusebenzeni konyango kwindlela yokwenyani yonyango, kwaye iqela le-Yu Baofa lichonge oyena nobangela womahluko. Unjingalwazi Merleau wawongwa ngeBhaso leNobel ngokufumana uphazamiseko lwe-RNA no-Andrew Farr ngowama-2006. Oku kufunyaniswe kutyhila indlela engundoqo apho iRNA enemisonto ephindwe kabini inokuthintela ngokuthe ngqo ukubonakaliswa kofuzo, ivule indlela yotshintsho yokufunda ukusebenza kwemfuza kunye nokuhlola oonobangela bezifo. Itekhnoloji yokuphazamiseka kwe-RNA iye yaba sisixhobo sembombo kuphando lwanamhlanje lwe-biomedical, ibonelela ngeembono ezintsha kunyango lwezifo ezahlukeneyo kubandakanya umhlaza. I-teknoloji yokuphazamiseka kwe-RNA kaNjingalwazi Melo kulindeleke ukuba isombulule ngokuchanekileyo le ngxaki kwaye iphucule kakhulu ukuhambelana nokusebenza konyango. Ukudityaniswa kobugcisa bamacala omabini ayiyompumelelo enkulu kuphela kunyango lomhlaza wepancreatic ehlabathini, kodwa kuya kuphucula ngokubanzi isiphumo sonyango “sonyango olucothayo lwethala leencwadi” kuwo onke amathumba aqinileyo.

Ukusukela kwi-academic resonance ngo-2016 ukuya kuphunyezo lwetekhnoloji yangoku, le ntsebenziswano ngumzekelo wokudityaniswa okunzulu phakathi kwempumelelo yophando lwenzululwazi yamazwe ngamazwe kunye nokusebenza kwezonyango zaseTshayina. Njengoko kuvandlakanywa nguGu Fangzhou, owayesakuba ngumongameli wePeking Union Medical College, uNjingalwazi uYu Baofa “uqalise uphando lwenzululwazi kwizibhedlele zabucala”. Ukuqaliswa kobuchwephesha beNjingalwazi uMelo akuyi kuphucula kuphela inqanaba lonyango lwe-tumor kwiindawo ezikufutshane kunye neendawo ezikufutshane, kodwa ziphinde zitshise isiqalo esitsha sobomi kwizigulane ezinomhlaza emhlabeni wonke, kwaye zikhuthaze imbangela yokuchasana nomhlaza kubantu ekuphakameni okutsha. Ngaphambi kohambo, uNjingalwazi uMerleau wachaza ngokuthe ngqo ukuba isayensi ayazi imida, kwaye ukulwa nomhlaza kufuna ubulumko behlabathi. “Ndijonge phambili kwintsebenziswano enzulu neqela likaNjingalwazi uYu Baofa ukujonga izisombululo zomhlaza ezisebenzayo kunye.