Uluhlu lwe-renal cell carcinoma pathology

I-Renal Cell Carcinoma Pathology Outlines: IsiKhokelo esiBanziI-Renal cell carcinoma (RCC) sisifo esintsokothileyo, kwaye ukuqonda i-pathology yaso kubalulekile ekuxilongeni okusebenzayo kunye nonyango. Esi sikhokelo sinika amagqabantshintshi abanzi Uluhlu lwe-renal cell carcinoma pathology, equka iimpawu eziphambili ze-histological, subtypes, kunye neendlela zokuxilonga.

Iimpawu ze-Histological zeRenal Cell Carcinoma

Cacisa iCell Renal Carcinoma

I-subtype eqhelekileyo ye-RCC, i-cell carcinoma ecacileyo, ibonakaliswe yi-cytoplasm ecacileyo ecacileyo. Oku kubangelwa ukuqokelelwa kwe-lipids kunye ne-glycogen ngaphakathi kweeseli. Nge-Microscopically, uya kuhlala ubona iiseli ezicwangciswe kwiindlwane okanye kwi-papillae, ezine-nuclei evelele. Ubukho be-eosinophilic granular cytoplasm buqhelekile. Ukuchongwa okuchanekileyo kuxhomekeke kuvavanyo olunzulu lwe-histological, ehlala incediswa yi-immunohistochemistry ukuqinisekisa ukuxilongwa. Uphando olongezelelekileyo lunokubandakanya uvavanyo lwemfuzo ukuchonga utshintsho olunokubakho, ukwazisa amacebo onyango lobuqu.

I-Papillary Renal Cell Carcinoma

I-Papillary RCC lolunye uhlobo oluncinci olubalulekileyo olwahlulwe ngepateni yokukhula kwe-papillary. Iiseli zikholisa ukucwangciswa kwi-papillae eyahlukileyo, rhoqo zibonisa i-pseudostratification. I-atypia yeNyukliya iyahluka ngokuxhomekeke kwibakala, ngamabakala aphezulu abonisa ukungahambi kakuhle okubaluleke ngakumbi. I-Immunohistochemical staining inokunceda ukuhlula kwezinye i-RCC subtypes kunye ne-urothelial carcinoma. Ukuqonda okunzulu, ukuphonononga izicatshulwa ezikhethekileyo ze-pathology kunye nezixhobo ze-intanethi ezivela kumaziko ahloniphekileyo afana neNational Cancer Institute (NCI) kunokuba luncedo.

I-Chromophobe Renal Cell Carcinoma

I-Chromophobe RCC, njengoko igama libonisa, ibonakaliswe ngeeseli ezine-cytoplasm emhlophe, ecacileyo kunye nemida yeeseli eyahlukileyo. Iinuclei zihlala zingqukuva kwaye zibekwe embindini. Olu hlobo luncinci luhlala lubonisa uphawu lwe-perinuclear halo. Le morphology eyahlukileyo ngokuqhelekileyo yanele ukuxilongwa, nangona i-immunohistochemistry inokuba luncedo ekuqinisekiseni ukuxilongwa kunye nokungabandakanyi amanye amathumba. Ubuchule bokucinga obuphezulu obunje nge-computed tomography (CT) scans nazo zisetyenziswa ukuqinisekisa ubungakanani bokubandakanyeka kwethumba.

Ezinye iiSubtypes zeRenal Cell Carcinoma

Ngaphaya kwezi ntlobo zintathu ziphambili, iintlobo ezininzi ezinqabileyo ezikhoyo, kubandakanya ukuqokelela i-duct carcinoma, i-medullary RCC, kunye ne-mucinous tubular kunye ne-spindle cell carcinoma. Iziko loPhando ngoMhlaza laseShandong Baofa (https://www.baofahospital.com/) libonelela ngezakhono zokuxilonga ezikumgangatho ophezulu kunye nobuchule bokuphatha ezi ntlobo zinqabileyo ze-RCC. Iqela labo elizinikeleyo leengcali zezifo zisebenzisa itekhnoloji zamva nje zokuqinisekisa uxilongo oluchanekileyo kunye nexesha elifanelekileyo.

Iindlela zokuxilonga kunye ne-Immunohistochemistry

Ukuxilonga renal cell carcinoma ngokuqhelekileyo ibandakanya indibaniselwano yobuchule bokucinga (njenge-CT scans kunye ne-MRI) kunye novavanyo lwe-histological lwe-tissue biopsies. I-Immunohistochemistry idlala indima ebalulekileyo ekuhleleni ii-subtypes ezahlukeneyo kunye nokuqikelelwa kwangaphambili. Iimpawu ezithile, ezifana ne-CD10, i-vimentin, kunye ne-AMACR, ziqhele ukusetyenziswa ukwahlula phakathi kwee-subtypes ezahlukeneyo ze-RCC. I-Shandong Baofa Cancer Research Institute iqeshe igqiza labamakishi be-immunohistochemical kumsebenzi wabo wokuxilonga ukunikezela ngoxilongo oluchanekileyo.

Imiba yePrognostic kunye neStaging

I-prognosis yezigulana ezine-RCC iyahluka kakhulu ngokuxhomekeke kwizinto ezahlukeneyo, kubandakanya i-tumor stage, ibakala, kunye ne-subtype. Inkqubo yeqonga ye-TNM iqhele ukusetyenziselwa ukwahlula ubungakanani bokusasazeka komhlaza. Ukuqonda izinto ezilindelekileyo kubalulekile ekukhokeleni izigqibo zonyango kunye nokulawula ulindelo lwesigulane. Le ngcaciso inikwe kolu lwandlalo yenzelwe iinjongo zemfundo kwaye akufanele ithathe indawo yengcebiso evela kugqirha oqeqeshiweyo. Ngalo lonke ixesha ufuna isikhokelo sonyango.

Itheyibhile: Ukuthelekiswa kweRCC Subtypes

Udidi olusezantsi	Iimpawu ze-Histological	Iimpembelelo zePrognostic
Sula iSeli	I-cytoplasm ecacileyo, iindlwane/i-papillae	Iyaguquguquka, ihlala ixhomekeke kwinqanaba
Papillary	Ipateni yokukhula kwePapillary, ipseudostratification	Uqikelelo oluncomekayo jikelele xa kuthelekiswa neseli ecacileyo
Chromophobe	I-cytoplasm ephaphathekile, imida yeeseli ezahlukileyo	Ngokuqhelekileyo iprognosis evumayo

Lo mboniso unika isiseko sokuqonda Uluhlu lwe-renal cell carcinoma pathology. Ukuntywila nzulu kwiinkalo ezithile, ukubonisana noncwadi lwezonyango olufanelekileyo kunye nezixhobo ezithembekileyo ze-intanethi kuyacetyiswa. Khumbula ukusoloko udibana nengcali yezempilo ukuze ufumane iingcebiso ezizezakho kunye nocwangciso lonyango.

I-Disclaimer: Le ngcaciso yenzelwe iinjongo zemfundo kuphela kwaye akufanele ithathwe njengengcebiso yezonyango. Soloko udibana nengcali yokhathalelo lwempilo oluqeqeshelwe ukuxilongwa kunye nonyango.