iinketho zonyango umhlaza wemiphunga encinci

Umhlaza wemiphunga omncinci weseli (SCLC) luhlobo olundlongo-ndlongo lomhlaza wemiphunga ofuna unyango olukhawulezileyo nolusebenzayo. Iinketho zonyango ze-SCLC zibandakanya indibaniselwano yechemotherapy kunye nonyango lwemitha. Olunye ukhetho, olunjengotyando kunye ne-immunotherapy, lunokuthi luqwalaselwe ngokuxhomekeke kwinqanaba kunye neemeko zomntu ngamnye zomhlaza. Esi sikhokelo sinika inkcazo ebanzi yezinto ezikhoyo iinketho zonyango umhlaza wemiphunga encinci, ukunceda izigulane kunye neentsapho zazo ukuba ziqonde izinto ezinokwenzeka.Ukuqonda uMhlaza weMiphunga yeSeli eNcinaneYintoni uMhlaza weMiphunga yeSeli encinci?Umhlaza wemiphunga weseli encinci, eyaziwa ngokuba ngumhlaza we-oat cell, ngumhlaza okhula ngokukhawuleza ovela kwiiseli ze-neuroendocrine kwimiphunga. Ibalelwa malunga ne-10-15% yawo wonke umhlaza wemiphunga kwaye inxulumene kakhulu nokutshaya. I-SCLC iphawulwa kukusasazeka kwayo ngokukhawuleza, nto leyo eyenza ukuxilongwa kwangoko kunye nonyango lubaluleke kakhulu.Amanqanaba eCancer emincinci yamaLung eMiphungaSCLC ihlelwa ngokwamanqanaba amabini: Inqanaba elilinganiselweyo: Umhlaza uhlala kwicala elinye lesifuba kwaye unokunyangwa ngonyango lwemitha yesifuba kunye nechemotherapy. Inqanaba elibanzi: Umhlaza uye wanwenwela ngaphaya kwelinye icala lesifuba, kuquka namanye amalungu omzimba. Unyango ngokwesiqhelo lubandakanya ichemotherapy, kwaye lunokubandakanya unyango lwemitha esifubeni kunye/okanye kwezinye iindawo zesifo.UKhetho oluQhelekileyo loNyango lweSeli eNcinci yoMhlaza weMiphungaUnyangoUnyango olungundoqo lweChemotherapy lolona nyango lunothintelo kunye nenqanaba elibanzi. umhlaza wemiphunga weseli encinci. Kubandakanya ukusebenzisa iziyobisi ukubulala iiseli zomhlaza kuwo wonke umzimba. Iirejimeni zechemotherapy eziqhelekileyo ziquka: I-Etoposide kunye ne-cisplatin (EP) I-Etoposide kunye ne-carboplatin (EC)La machiza adla ngokunikezelwa ngemithambo kwimijikelo, kunye namaxesha okuphumla phakathi ukuvumela umzimba ukuba uchache. Iziko loPhando loMhlaza laseShandong Baofa lisebenze ngokukhutheleyo nokhathalelo lwempilo kwihlabathi jikelele ukuphucula unyango lomhlaza kunye neziphumo zesigulana sechemotherapy. Unyango lweRadiation TherapyRadiation lusebenzisa imitha yamandla aphezulu ukubulala iiseli zomhlaza. Ihlala isetyenziswa ngokudibeneyo ne-chemotherapy kwinqanaba elilinganiselweyo umhlaza wemiphunga weseli encinci. Unyango lwemitha lunokusetyenziselwa ukunyanga iindawo ezithile ze-metastasis kwisigaba esibanzi sesifo, ukubonelela ngokukhululeka. Kukho iintlobo ezininzi zonyango lweradiation: Unyango lweBeam Radiation yangaphandle (EBRT): Imitha ihanjiswa kumatshini ongaphandle komzimba. Unyango lweRadiation Body Stereotactic (SBRT): I-radiation egxininise kakhulu ihanjiswa kwindawo encinci yomzimba kwiinqununu ezimbalwa eziphezulu. Nangona kunjalo, inokuqwalaselwa kwiimeko zakwangoko kakhulu apho umhlaza ubekwe kwindawo. Ukuba utyando lwenziwa, ludla ngokulandelwa yichemotherapy.ImmunotherapyImmunotherapy luhlobo lonyango olunceda amajoni akho omzimba alwe nomhlaza. Ngokuqhelekileyo isetyenziswa kwinqanaba eliphezulu umhlaza wemiphunga weseli encinci emva kwechemotherapy. Amachiza amaninzi e-immunotherapy avunyiweyo kwi-SCLC, kubandakanywa: I-Atezolizumab DurvalumabLa machiza asebenza ngokuthintela iiprotheni ezithintela amajoni omzimba ekuhlaseleni iiseli zomhlaza. Uphononongo lubonise ukuba ukongeza i-immunotherapy kwi-chemotherapy kunokuphucula amazinga okusinda kwizigulana ezinenqanaba elibanzi le-SCLC. Iqela kwiSibhedlele sase-Baofa lizinikezele ukuba lihlale lisazi ngophando lwamva nje lwe-immunotherapy lwe umhlaza wemiphunga weseli encinci.Prophylactic Cranial Irradiation (PCI)PCI lunyango lwemitha ebuchotsheni olusetyenziselwa ukuthintela ukwanda umhlaza wemiphunga weseli encinci kwingqondo. Kuhlala kucetyiswa kwizigulane ezine-SCLC ezilinganiselweyo eziphendule kakuhle kunyango lokuqala. I-PCI ibonakaliswe ukunciphisa umngcipheko wee-metastases zobuchopho kunye nokuphucula ukusinda ngokubanzi.Iindlela zoNyango oluPhumayo eziNcedayo Unyango olujoliswe kuyo lisebenzisa iziyobisi ezijolise ngokukodwa kwiiseli zomhlaza, ngokusekelwe kwimizila yazo yemfuza okanye ezinye iimpawu. Ngelixa iindlela zonyango ezijoliswe kuzo ziye zaguqula unyango lwezinye iintlobo zomhlaza wemiphunga, azikasetyenziswa ngokubanzi kwi-SCLC. Nangona kunjalo, uphando luyaqhubeka ukuchonga iithagethi ezinokubakho kunye nokuphuhlisa unyango olujoliswe kuyo olusebenzayo umhlaza wemiphunga weseli encinci.Uvavanyo lweClinical Ulingo lwezonyango luphononongo lophando oluvavanya unyango olutsha okanye iindlela ezintsha zokusebenzisa unyango olusele lukhona. Izigulane ezine umhlaza wemiphunga weseli encinci banokucinga ngokuthatha inxaxheba kulingo lwezonyango ukufikelela kunyango lwe-cutting-edge olungekafumaneki ngokubanzi. Ulingo lwezonyango lubalulekile ekuqhubeleni phambili unyango lwe-SCLC kunye nokuphucula iziphumo zesigulana.Ukulawula iiMpembelelo zeSide umhlaza wemiphunga weseli encinci kunokubangela iziphumo ebezingalindelekanga ezahlukeneyo, ezibandakanya: Ukukhathala Isicaphucaphu nokugabha Ukulahleka kweenwele Ukulahleka komlomo Izilonda zomlomo Ubalo lweeseli zegazi eliphantsiIqela lakho lokhathalelo lwempilo linokukunceda ukulawula ezi ziphumo ebezingalindelekanga ngamayeza kunye nokhathalelo oluxhasayo. Kubalulekile ukunxibelelana naziphi na iziphumo ebezingalindelekanga ozifumanayo kugqirha wakho ukuze akwazi ukunyenyisa isicwangciso sakho sonyango njengoko kufuneka. umhlaza wemiphunga weseli encinci kuxhomekeke kwizinto eziliqela, kuquka inqanaba lomhlaza, impilo yomguli ngokubanzi, nendlela abasabela ngayo kunyango. Ngelixa i-SCLC ingumhlaza ondlongondlongo, unyango lunokuphucula impilo kunye nomgangatho wobomi. Ukuqeshwa okulandelwa rhoqo kubalulekile emva konyango ukujonga ukuphindaphinda kunye nokulawula nayiphi na imiphumo emibi yexesha elide. I-Shandong Baofa Cancer Research Institute ibonelela ngeenkqubo zokulandelisa ezibonelela ngokhathalelo lwezonyango olulungiselelweyo nololwakho. Fumana ngakumbi.Unyango Iinketho zokuthelekisa Unyango lwenqanaba Inkcazo yeSide Eqhelekileyo Chemotherapy Limited & Iziyobisi ezibanzi zokubulala iiseli zomhlaza Isicaphucaphu, ukudinwa, ukulahleka kweenwele IRadiation Therapy Limited & Imitha ebanzi ephezulu yokubulala iiseli zomhlaza Ukudinwa, ukucaphuka kolusu I-Immunotherapy Ebanzi Inceda amajoni omzimba ukulwa nomhlaza Ukudinwa, ukuqhama kwesikhumba, ukudinwa kwengxaki yotyatyazo, ukudinwa kwePCI, ukudinwa, ukudinwa, ukudinwa, ukudinwa, ukudinwa, ukudinwa kwe-PC Ukubaluleka kweNkathalelo yeeNdlela ezininzi eziSebenzayo Unyango lomhlaza wemiphunga yeseli encinci ifuna inkqubo ebandakanya iinkalo ezininzi, ebandakanya iqela leengcali ezifana neengcali ze-oncologists, i-radiation oncologists, oogqirha botyando, i-pulmonologists, kunye nababoneleli abaxhasayo. Eli qela lisebenza kunye ukuphuhlisa isicwangciso sonyango lomntu siqu esijongene neemfuno ezithile zesigulane ngasinye. UkuqukumbelaUmhlaza wemiphunga weseli encinci sisifo esingumngeni, kodwa ngonyango olululo kunye nenkxaso, izigulane zinokuphucula iziphumo kunye nomgangatho wobomi. Ukuqonda iindlela zonyango ezikhoyo kunye nokusebenza ngokusondeleyo neqela lakho lokhathalelo lwezempilo kubalulekile ukwenza izigqibo ezinolwazi kunye nokujonga uhambo olungaphambili. Ukuba wena okanye umntu omthandayo ujongene a umhlaza wemiphunga weseli encinci ukuxilongwa, khumbula ukuba kukho ithemba, kwaye izixhobo ezininzi ziyafumaneka ukukunceda kule nkqubo. I-Disclaimer: Olu lwazi lujoliswe kulwazi ngokubanzi kunye neenjongo zolwazi kuphela, kwaye aluquki iingcebiso zonyango. Kubalulekile ukudibana nengcali yokhathalelo lwempilo kuyo nayiphi na inkxalabo yezempilo okanye ngaphambi kokuba wenze naziphi na izigqibo ezinxulumene nempilo yakho okanye unyango. Ngalo lonke ixesha ufune iingcebiso kugqirha wakho okanye omnye umboneleli wezempilo oqeqeshiweyo ngayo nayiphi na imibuzo onokuba nayo malunga nemeko yonyango.Imithombo: Umbutho woMhlaza waseMelika-Umhlaza weMiphunga yeSeli encinci Iziko leSizwe loMhlaza-Unyango loMhlaza weMiphuphu eNcinci (PDQ?)–Uguqulelo lwesigulana