unyango Unikezelo lweziyobisi lwasekhaya loMhlaza

Unyango loNikezelo lweziyobisi lwasekhaya loMhlaza

Eli nqaku libonelela ngamagqabantshintshi abanzi kwiinkqubo zokuhanjiswa kweziyobisi zasekhaya kunyango lomhlaza, ukuhlola iindlela ezahlukeneyo, iingenelo, imida, kunye nezalathiso zexesha elizayo. Sihlola iindlela, izicelo zeklinikhi, kunye neenzame zophando eziqhubekayo kule ntsimi eguqukayo ngokukhawuleza. Funda malunga nenkqubela phambili yamva nje kunyango ekujoliswe kulo olujolise ekwandiseni ukusebenza kakuhle ngelixa kuncitshiswa iziphumo ebezingalindelekanga zenkqubo.

Ukuqonda uHanjiso lweziyobisi lwasekuhlaleni

Yintoni uHanjiso lweziyobisi lwaseKhaya?

Ukuhanjiswa kweziyobisi endaweni kuba umhlaza ubhekisa kwiindlela ezihambisa amayeza onyango ngokuthe ngqo kwindawo yethumba, ukunciphisa ukuvezwa kwezicubu ezisempilweni. Le ndlela ekujoliswe kuyo ijolise ekuphuculeni ukusebenza kakuhle, ukunciphisa ubuthi, kunye nokuphucula iziphumo zesigulane xa kuthelekiswa nonyango lwesintu lwenkqubo. Kusetyenziswa iindlela ezininzi, nganye kuzo ineengenelo kunye nemida yayo.

IiNdlela zokuHanjiswa kweziyobisi kwasekhaya

Zininzi iindlela eziququzelelayo ukuhanjiswa kweziyobisi endaweni, kubandakanywa: ukufakelwa kwezixhobo zokuhlanjululwa kweziyobisi (umzekelo, iipolymers eziphilayo, i-microspheres), i-injection ye-agent zonyango ngokuthe ngqo kwi-tumor, kunye nokusetyenziswa kwe-nanoparticles ekujoliswe kuyo eziqokelela ngokukhethekileyo kwizicubu ze-tumor. Ezi ndlela zixhaphaza iimpawu ezizodwa ze-tumor microenvironment ukuphucula ukugxilwa kweziyobisi kwindawo ekujoliswe kuyo.

Iindidi zeeNkqubo zoNikezelo lweziyobisi zasekuhlaleni

Izixhobo ezifakelwayo

Izixhobo ezimiliselweyo, ezifana neepolymers ezinokonakala kunye ne-microspheres, zibonelela ngokukhululwa okuqhubekayo kweearhente ze-chemotherapeutic ngokuhamba kwexesha. Le ndlela inciphisa ubuninzi bolawulo kwaye inokuphucula ukuthotyelwa kwesigulane. Nangona kunjalo, izinga lokukhululwa kunye nobude budinga ukulungiswa ngononophelo ukufezekisa umphumo ofunekayo wonyango. Iziko loPhando ngoMhlaza iShandong Baofa liphambili kuphando kwezi ndawo.

Izitofu

Isitofu ngokuthe ngqo samachiza kubunzima bethumba yenye indlela eqhelekileyo. Le ndlela ibonelela ngoxinzelelo oluphezulu lwamachiza engingqi kodwa isenokungalungeli zonke iintlobo zethumba okanye iindawo. Le ndlela yobugcisa isoloko isetyenziswa ngokudityaniswa nezinye iindlela zokucinga ukujolisa okuchanekileyo.

Ukuhanjiswa kweNanoparticle

I-Nanoparticle-based ukuhanjiswa kweziyobisi endaweni Iinkqubo ziphakamisa ukunyanzeliswa okuphuculweyo kunye nokugcinwa (EPR) umphumo we-tumor vasculature. Ezi nanoparticles zithwala iyeza kwi-tumor, ziqokelela ngokukhetha ngenxa yemithambo yegazi evuzayo. Nangona kunjalo, ukufezekisa ukujoliswa kwe-tumor esebenzayo kunye nokulawula ukukhutshwa kwe-nanoparticle kuhlala kuyimingeni ebalulekileyo. Ukuphuhliswa kweenoveli ze-nanoparticles ezineempawu eziphuculweyo ezijoliswe kuyo yindawo esebenzayo yophando.

Izicelo zeklinikhi kunye noPhando oluqhubekayo

Izicelo zeklinikhi zangoku

Ukuhanjiswa kweziyobisi endaweni iinkqubo ngoku kusetyenziswa unyango umhlaza ezahlukeneyo, kuquka: amathumba ebuchotsheni (usebenzisa wafers implantable), umhlaza wedlala (usebenzisa brachytherapy), kunye neentlobo ezithile zomhlaza webele. Indlela ethile ekhethiweyo ixhomekeke kuhlobo kunye nesigaba somhlaza.

Uluhlu 1: Uthelekiso lwezinto ezahlukeneyo ukuhanjiswa kweziyobisi endaweni iindlela.

Izalathiso zexesha elizayo

Uphando lwexesha elizayo kwi ukuhanjiswa kweziyobisi endaweni iya kujolisa ekuphuculeni okuthe ngqo, ekwandiseni i-kinetics yokukhupha ichiza, kunye nokuphuhlisa iimoto ezintsha zokuhambisa amachiza. Ukudibanisa ukuhanjiswa kweziyobisi endaweni kunye nezinye iindlela zonyango, ezinje ngonyango lwe-immunotherapy, zinokuphucula iziphumo zonyango. Ukubanakho ukwenziwa komntu ukuhanjiswa kweziyobisi endaweni, elungiselelwe iimpawu zesigulane ngasinye, nayo iyindawo ebalulekileyo yomdla.

Ngolwazi oluthe kratya malunga nophando lomhlaza kunye neendlela zonyango, nceda undwendwele i IZiko loPhando ngoMhlaza laseShandong Baofa iwebhusayithi.