unyango lwempumelelo entsha yonyango lomhlaza wemiphunga ngo-2020

UPhumeleleke oMtsha woNyango loMhlaza weMiphunga: 2020 naNgaphaya

Eli nqaku linika isishwankathelo senkqubela phambili ebalulekileyo unyango lwempumelelo entsha yonyango lomhlaza wemiphunga ngo-2020 nangaphaya. Siphonononga uphuhliso oluphambili kwiindlela zonyango ezijoliswe kuzo, i-immunotherapies, kunye nezinye iindlela ezintsha, ezigxininise ekusebenzeni kwazo kunye nefuthe elinokubakho kwiziphumo zesigulane. Funda ngophando lwamva nje kunye nolingo lweklinikhi oluqhubekayo olubumba ikamva lokhathalelo lomhlaza wemiphunga.

Unyango olujoliswe kuyo: I-Precision Medicine ithatha iSiteji seZiko

Ukuqhubela phambili kwi-EGFR kunye ne-ALK Inhibitors

Inkqubela phambili ebalulekileyo yenziwe kwiindlela zonyango ezijoliswe kuzo, ngakumbi kwizigulane ezineenguqu ezithile zofuzo. Unyango lwempumelelo entsha yonyango lomhlaza wemiphunga ngo-2020 ubone ukuvunywa kwee-EGFR ezintsha kunye ne-ALK inhibitors, ezibonelela ngokusebenza okuphuculweyo kunye nokunyamezela xa kuthelekiswa nezizukulwana zangaphambili. La machiza ajolise ngokukhethekileyo kwiiseli zomhlaza ngolu tshintsho, enciphisa umonakalo kwizicubu eziphilileyo. Umzekelo, uphuhliso lwesizukulwana sesithathu se-EGFR inhibitors lubonise isithembiso ekoyiseni ukuxhathisa kunyango lwangaphambili. Uphando olongezelelekileyo luyaqhubeka nokuphonononga ukubanako kolu nyango lujoliswe kuko ngokudityaniswa nolunye unyango.

I-Immunotherapies: Ukubophelela Amandla eNkqubo yokuKhusela umzimba

Ii-Checkpoint Inhibitors kunye nendima yazo kuNyango lomhlaza wemiphunga

I-Immunotherapies, edibanisa amajoni omzimba ukulwa nomhlaza, iye yatshintsha unyango lwempumelelo entsha yonyango lomhlaza wemiphunga ngo-2020. I-Checkpoint inhibitors, njenge-PD-1 kunye ne-PD-L1 inhibitors, ibonise impumelelo ephawulekayo ekwandiseni ubomi kwizigulana ezinomhlaza wemiphunga ophezulu. La machiza avimba imiqondiso esetyenziswa ziiseli zomhlaza ukuphepha amajoni omzimba, evumela iiseli zomzimba ukuba zihlasele kwaye zitshabalalise ithumba. Nangona kunjalo, ayizizo zonke izigulana eziphendulayo kwi-immunotherapy, kwaye uphando luyaqhubeka ukuchonga i-biomarkers ukuqikelela ukuba zeziphi izigulana eziza kuxhamla kakhulu. Ngaphaya koko, amaphononongo ajonga ukusetyenziswa kwe-immunotherapy ngokudityaniswa nolunye unyango, olufana nechemotherapy okanye unyango ekujoliswe kulo, ukuze kuphuculwe ukusebenza kakuhle.

Ezinye Iindlela Ezithembisayo

Unyango olusakhulayo kunye novavanyo lweklinikhi oluqhubekayo

Ngaphandle konyango ekujoliswe kulo kunye ne-immunotherapies, ezinye iindlela ezininzi ezithembisayo ziphandwa unyango lwempumelelo entsha yonyango lomhlaza wemiphunga ngo-2020. Ezi ziquka iirejimeni ezintsha zechemotherapy, ukuqhubela phambili kunyango lwemitha (ezifana ne-stereotactic body radiotherapy okanye i-SBRT), kunye neenkqubo ezintsha zokuhanjiswa kwechiza. Ulingo oluninzi lwezonyango luyaqhubeka, luvavanya ukusebenza kolu nyango lutsha kunye nokuphonononga indibaniselwano enokubakho ukuze kwandiswe iziphumo. Ukuhlala unolwazi malunga nolingo lwezonyango oluqhubekayo kubalulekile kwizigulane kunye neentsapho zazo ezifuna olona khetho luphezulu zonyango. ClinicalTrials.gov sisixhobo esixabisekileyo sokufumana ulwazi ngolingo lwangoku.

Ikamva Lonyango Lomhlaza Wemiphunga

Ubume bonyango lomhlaza wemiphunga buhlala buguquka, kunye nophando oluqhubekayo kunye nophuhliso lutyhala imida yento enokwenzeka. Ukudityaniswa kweyeza elichanekileyo, i-immunotherapy, kunye nezinye iindlela ezintsha zinesithembiso esikhulu sokuphucula iziphumo zezigulane kunye namazinga okuphila. Kubalulekile ukuba abantu abajongene nokuxilongwa ngumhlaza wemiphunga badibane nogqirha wabo we-oncologist ukuze baxoxe ngesona sicwangciso sifanelekileyo sonyango esilungiselelwe imeko yabo ethile kunye neprofayili yemfuza. Kukhathalelo olubanzi lomhlaza, cinga ngokujonga ubuchule obukhoyo kumaziko afana ne IZiko loPhando ngoMhlaza laseShandong Baofa.

Uthelekiso lweDatha: UNyango oluPhambili oluPhambili ()

Qaphela: Olu lwazi lololwazi ngokubanzi kunye neenjongo zolwazi kuphela, kwaye aluquki iingcebiso zonyango. Soloko udibana nengcali yokhathalelo lwempilo kuyo nayiphi na inkxalabo yezempilo okanye ngaphambi kokuba wenze naziphi na izigqibo ezinxulumene nempilo okanye unyango lwakho.