inqanaba lonyango 3 non small cell cancer lung cancer unyango

IiNdlela zoNyango lweNqanaba lesi-3 loMhlaza weMiphunga engeNcinci

Inqanaba lesi-3 lomhlaza wemiphunga weseli engeyiyo encinci (NSCLC) libonisa imingeni eyodwa, efuna indlela yonyango ebandakanya izinto ezininzi. Esi sikhokelo sibanzi siphonononga iindlela ezahlukeneyo zonyango, sichaza ukusebenza kwazo, iziphumo ebezingalindelekanga ezinokwenzeka, kunye nokufaneleka ngokuxhomekeke kwimiba yesigulane ngasinye. Ukuqonda olu khetho kubalulekile ukwenza izigqibo ezinolwazi kunye ne-oncologist yakho.

Ukuqonda iNqanaba lesi-3 le-NSCLC

Inqanaba lesi-3 le-NSCLC lihlelwe kwiNqanaba IIIA kunye ne-IIIB, ebonisa ubungakanani bokusasazeka komhlaza. Inqanaba IIIA libandakanya umhlaza oye wasasazeka kwii-lymph nodes ezikufutshane, ngelixa i-Stage IIIB ibandakanya ukubandakanyeka kwe-lymph node kunye / okanye ukusasazeka kwizakhiwo ezikufutshane. Ukulinganisa okuchanekileyo ngokujonga (i-CT scans, i-PET scans) kunye ne-biopsies ibalulekile ekuqinisekiseni eyona nto ifanelekileyo. unyango isigaba 3 non-incinci unyango umhlaza wemiphunga cell isicwangciso.

IiNdlela zoNyango lweNqanaba lesi-3 le-NSCLC

Utyando

Utyando lunokuba lukhetho lwezigulane ezikhethiweyo zeSigaba IIIA ezinokubandakanyeka okulinganiselweyo kunye nempilo enhle iyonke. Oku kunokubandakanya i-lobectomy (ukususwa kwe-lung lobe) okanye i-pneumonectomy (ukususwa komphunga uphela). Ukutshatyalaliswa kokuhlinzwa kudla ngokulandelwa unyango lwe-adjuvant (i-chemotherapy okanye i-radiation) ukunciphisa umngcipheko wokuphindaphinda. Isigqibo sokuqhubeka notyando sixhomekeke kwizinto eziliqela, kuquka indawo kunye nobukhulu bethumba, impilo yesigulana ngokubanzi, kunye nobungakanani bokubandakanyeka kwe-lymph node. IZiko loPhando ngoMhlaza laseShandong Baofa inika ubuchule botyando olubanzi lomhlaza wemiphunga.

Unyango ngamachiza

I-Chemotherapy, ukusebenzisa amayeza anamandla okubulala iiseli zomhlaza, yinto eqhelekileyo unyango isigaba 3 non-incinci unyango umhlaza wemiphunga cell kwiNqanaba IIIA kunye ne-IIB NSCLC. Iirejimeni ziyahluka ngokuxhomekeka kwizinto zomntu ngamnye, kwaye zinokubandakanya amachiza asekelwe kwiplatinam (i-cisplatin okanye i-carboplatin) edityaniswe nezinye ii-agent ezifana ne-pemetrexed okanye i-docetaxel. I-Chemotherapy inokulawulwa phambi kotyando (neoadjuvant) ukucutha ithumba, emva kotyando (adjuvant) ukuphelisa iiseli zomhlaza eziseleyo, okanye njengonyango lokuqala. Iziphumo ebezingalindelekanga ziqhelekile kwaye zinokubandakanya isicaphucaphu, ukudinwa, nokulahleka kweenwele; nangona kunjalo, ezi zihlala zilawuleka ngenkathalo yenkxaso.

Unyango ngemitha

Unyango ngemitha lusebenzisa imitha yemitha ephezulu ukutshabalalisa iiseli zomhlaza. Ingasetyenziswa yodwa okanye idibene nechemotherapy. Unyango lwemitha lunokusetyenziswa phambi kotyando (neoadjuvant) ukucutha ithumba, emva kotyando (adjuvant) ukujolisa kuzo naziphi na iiseli zomhlaza eziseleyo, okanye njengolona nyango luphambili, ngakumbi kwizigulana ezingengabo abaviwa botyando. Unyango lwemitha ye-Stereotactic body radiation (SBRT) luhlobo oluchanekileyo lwemitha yemitha ehambisa iidosi eziphezulu zemitha yemitha kwithumba ngelixa igcina izicubu ezisempilweni ezingqongileyo. Uhlobo oluthile kunye nethamo lonyango lwemitha luxhomekeke kwimeko yomntu.

Unyango ekujoliswe kulo

Unyango ekujoliswe kulo lusebenzisa amachiza ajolise ngokukodwa kwiiseli zomhlaza ngokusekelwe kwiinguqu zabo zemfuza. Ukuguqulwa kofuzo oluthile (njenge-EGFR, ALK, ukuguqulwa kwe-ROS1) kuqhelekileyo kwi-NSCLC kwaye kunokuqikelela ukuphendula kwiindlela zonyango ezijoliswe kuzo. Ukuba olo tshintsho luchongiwe, unyango olujoliswe kuyo lunokuba sisiseko sembombo unyango isigaba 3 non-incinci unyango umhlaza wemiphunga cell, ezinokuthi zinike iziphumo eziphuculweyo kunye neziphumo ebezingalindelekanga ezimbalwa xa kuthelekiswa nechemotherapy yendabuko. I-oncologist yakho iya kuqhuba uvavanyo lwezofuzo ukujonga ukuba unyango olujoliswe kuyo lufanelekile kuwe.

Immunotherapy

I-Immunotherapy isebenzisa amandla amajoni omzimba okulwa nomhlaza. I-immune checkpoint inhibitors, njenge-nivolumab okanye i-pembrolizumab, isetyenziselwa ukuvala iiprotheni ezithintela amajoni omzimba ekuhlaseleni iiseli zomhlaza. Unyango lwe-Immunotherapy luhlala lusetyenziswa ngokudibeneyo nechemotherapy kwaye lunokuba lukhetho lwezigulane ezineeprofayili ezithile zofuzo okanye abo bangakhange baphendule kakuhle kolunye unyango. Imiphumo emibi inokwenzeka kwaye iyahluka ngokuxhomekeke kwiyeza elithile.

Ukukhetha iSicwangciso soNyango esiLungileyo

Elona liphezulu unyango isigaba 3 non-incinci unyango umhlaza wemiphunga cell isicwangciso sixhomekeke kwizinto eziliqela, kuquka inqanaba lomhlaza, impilo yesigulana iyonke, kunye nobukho beenguqu ezithile zofuzo. Iqela lezinto ezininzi ze-oncologists, oogqirha botyando, kunye neengcali zonyango ngemitha ziya kusebenza ngokubambisana ukuphuhlisa isicwangciso sonyango lomntu. Unxibelelwano oluvulekileyo kunye nomboneleli wakho wezempilo kubalulekile ukuqonda iinketho zakho kunye nokwenza izigqibo ezinolwazi malunga nokhathalelo lwakho.

Le ngcaciso yenzelwe iinjongo zemfundo kuphela kwaye akufanele ithathwe njengengcebiso yezonyango. Soloko udibana nomboneleli wakho wezempilo ukuze ufumane ukuxilongwa kunye nonyango lwazo naziphi na iimeko zonyango.

I-Disclaimer: Olu lwazi lujoliswe kulwazi ngokubanzi kunye neenjongo zolwazi kuphela, kwaye aluquki iingcebiso zonyango. Kubalulekile ukudibana nengcali yokhathalelo lwempilo kuyo nayiphi na inkxalabo yezempilo okanye ngaphambi kokuba wenze naziphi na izigqibo ezinxulumene nempilo yakho okanye unyango. Ulwazi olunikelwe apha akufuneki luthathelwe indawo ingcebiso yezonyango, ukuxilongwa, okanye unyango.