unyango Ukukhutshwa okuZinzileyo koNyango loNikezelo lweziyobisi

Unyango loNyango oluZinzileyo loNikezelo lweziyobisi

Esi sikhokelo sibanzi siphonononga ukuntsonkotha kwe Unyango oluzinzileyo lonikezelo lweyeza, ukuphonononga iindlela zayo, iingenelo, imingeni, kunye nolwalathiso lwexesha elizayo. Singena kwizicelo ezahlukeneyo, sithathela ingqalelo iintlobo ezithile zamachiza kunye nenani lezigulane, sibonelela ngokuqonda okucacileyo kwale ndlela yonyango yonyango.

Ukuqonda Ukuhanjiswa kweziyobisi okuZinzileyo

Yintoni iSustained Release Delivery Therapy?

Ukukhululwa konyango lokunikezelwa kweziyobisi, ekwaziwa njengonikezelo lwechiza elikhutshwayo olulawulwayo, bubuchule boxubo bomayeza obuyilelwe ukulawula umlinganiselo wokukhutshwa kwechiza kuhlobo lwedosi yalo. Ngokungafaniyo nemixube ekhutshwe kwangoko apho iyeza likhutshwa ngokukhawuleza, iinkqubo zokukhutshwa okuzinzileyo zijolise ekuboneleleni ngesiphumo esingaguqukiyo kunye nexesha elide lonyango kwixesha elongeziweyo. Le ndlela inciphisa ukuguquguquka kokugxilwa kwe-plasma yechiza, ukunciphisa ukuphindaphinda kolawulo kunye nokuphucula ukuthotyelwa kwesigulana. Iinkqubo ezithile ezibandakanyekayo ziyahluka ngokuxhomekeke kulwakhiwo, kwaye ezi nkqubo zinokubandakanya ubugcisa obahlukeneyo obufana neenkqubo zematrix, iisistim zedama, kunye neempompo ze-osmotic. Eyona njongo iphambili kukusebenza konyango oluphuculweyo kunye neziphumo eziphuculweyo zesigulane.

IiNdlela kunye nobuGcisa

Iindlela ezininzi ezixhasa ukusebenza kwe Ukukhutshwa okuzinzileyo konyango lokuhanjiswa kweziyobisi. Ezi ziquka iinkqubo ezilawulwa yi-diffusion, apho iyeza lisasazeka nge-polymeric matrix; iinkqubo ezilawulwa ngokukhukuliseka, apho i-matrix ngokwayo iyancipha ngokuhamba kwexesha, ukukhulula iyeza; kunye neenkqubo ezilawulwa yi-osmotic, ezisebenzisa uxinzelelo lwe-osmotic ukulawula ukukhutshwa kweziyobisi. Ukhetho lwesixhobo kunye nobuchwepheshe buhlala bulungelelaniswe kwiipropati zechiza elithile kunye neprofayili yokukhululwa efunwayo.

Izibonelelo kunye nezicelo zokuhanjiswa kweziyobisi okuZinzileyo

UNyango oluFanelekileyo oluphuculweyo

Ngokugcina amanqanaba angatshintshiyo amachiza, Ukukhutshwa okuzinzileyo konyango lokuhanjiswa kweziyobisi ihlala ikhokelela kwiziphumo zonyango eziphuculweyo. Ukuguquguquka okucuthiweyo kunciphisa zombini umngcipheko wamanqanaba angaphantsi konyango (okukhokelela kukusilela kunyango) kunye nokugxila kwincopho enokuba yityhefu. Oku kunenzuzo ngakumbi kumachiza anesalathiso sonyango esimxinwa.

UkuPhuculwa kokuThotyelwa kweSigulana

Olona ncedo lubalulekileyo luphuculo lokuthotyelwa kwezigulane. Ukuncitshiswa kwezihlandlo zedosi ezinxulunyaniswa nemixube ekhutshwa ngokuqhubekayo yenza kube lula kwizigulane ukubambelela kwiirejimeni zamayeza amiselweyo. Oku kubalulekile kwiimeko ezingapheliyo ezifuna unyango lwexesha elide.

Ukuhanjiswa kweziyobisi ekuJoliswe kuzo

Ngelixa ingasoloko iyinxalenye yazo zonke iinkqubo ezikhutshwa ngokuzinzileyo, ezinye iimixube eziphucukileyo zibandakanya iindlela zonikezelo ekujoliswe kuzo. Ezi nkqubo zinokukhokelela iyeza kwizicubu ezithile okanye kumalungu athile, ngaloo ndlela ikhulisa isiphumo sonyango ngelixa inciphisa iziphumo ebezingalindelekanga kwezinye iindawo zomzimba. Lo mmandla wophando uqhubeka ukhula, ukhokelela kwizicelo ezitsha.

Imizekelo yoKhupho oluZinzileyo lweNkqubo yokuhanjiswa kweziyobisi

Amachiza amaninzi asebenzisa ubuchwephesha obuzinzileyo. Imizekelo ibandakanya kodwa ayiphelelanga kumayeza entliziyo (umzekelo, amanye amayeza e-beta-blockers), izithomalalisi zentlungu (umzekelo, i-opioid analgesics ethile), kunye ne-antipsychotics. Ukhetho lwenkqubo yonikezelo luxhomekeke kwizinto ezifana neepropathi zephysicochemical yechiza, iprofayili efunwayo yokukhupha, kunye neemfuno zesigulana ngasinye.

Imingeni kunye neMida

Uphuhliso Loqulunqo

Ukuqulunqa uqulunqo oluzinzileyo noluthembekileyo oluzinzileyo kunokuba ngumngeni. Izinto ezinjengokunyibilika kweziyobisi, ukuzinza, kunye nokusebenzisana okunokubakho kunye nenkqubo yokuhambisa kufuneka kuqwalaselwe ngononophelo.

Iindleko kunye nokuVeliswa

Amalungiselelo okukhutshwa okuzinzileyo ahlala ebandakanya iinkqubo zokwenziwa ezintsonkothileyo kunezo zikhutshwa kwangoko, ezikhokelela kwiindleko ezinokuba phezulu.

Iingqwalaselo Ngokuthe ngqo kumguli

Ngelixa ngokubanzi kunenzuzo, iipropathi ze-pharmacokinetic kunye ne-pharmacodynamic zokuqulunqwa kokukhululwa okuqhubekayo kunokwahluka ngokuxhomekeke kwimiba yesigulane ngasinye, kubandakanywa iminyaka yobudala, i-metabolism, kunye ne-co-morbidities. Ukubeka iliso ngononophelo kubalulekile.

Izalathiso zexesha elizayo kuNyango oluZinzileyo lokuKhupha ukuhanjiswa kweZiyobisi

Uphando luyaqhubeka ukutyhala imida ye Ukukhutshwa okuzinzileyo konyango lokuhanjiswa kweziyobisi. Inkqubela phambili kwi-nanotechnology, biomaterials, kunye nezixhobo ezifakelwayo zithembisa ngakumbi iindlela ezichane ngakumbi, ekujoliswe kuzo nezisebenzayo kwixesha elizayo. Oku kuquka ukuqhubela phambili kwiipholima ezikwazi ukubola, iinkqubo zokuphendula ukuvuselela, kunye neendlela zamayeza ezenzelwe umntu ngamnye ezilungiselelwe iimfuno zesigulana ngasinye.

Ngolwazi oluthe vetshe ngonyango lomhlaza kunye neenkonzo ezinxulumene noko, nceda undwendwele IZiko loPhando ngoMhlaza laseShandong Baofa.