I-Sustaged Reser Delivery Regived Therapy: Ukubuka okuphelele okuphelele 

I-Sustaged Reser Delivery Regived Therapy: Ukubuka okuphelele okuphelele

Le ndatshana inikeza incazelo enemininingwane ye Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo, Ukuhlola izindlela zayo, izinzuzo, izinhlelo zokusebenza, kanye nezinkomba zesikhathi esizayo. Sizosebenzisa ezinhlelweni ezahlukahlukene zokulethwa, sibhekane nezinzuzo nokulinganiselwa kwazo, futhi sihlole umthelela emiphumeleni yeziguli kanye nezindleko zokunakekelwa kwempilo. Imininingwane eyethulwe yenzelwe labo abafuna ukuqonda okujulile kwale ndawo ebalulekile yokuthuthuka nokwelashwa kwemithi.

Izindlela zokulethwa kwezidakamizwa okulondoloziwe kwezidakamizwa

Izindlela zokukhishwa ezilawulwayo

Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo Sithembela ezindongeni ezahlukahlukene ukulawula isilinganiso lapho umuthi ukhishwa emzimbeni. Lokhu kufaka phakathi izinhlelo ezilawulwa ukulawulwa, lapho umuthi uhluka khona nge-polymeric matrix; Izinhlelo ezilawulwa ukuguguleka, lapho kukhululwa khona umuthi njengoba i-polymer ehlanza khona; kanye namaphampu we-osmotic, asebenzisa ingcindezi ye-osmotic ukushayela ukukhishwa kwezidakamizwa. Ukukhethwa kwendlela kuncike ezicini zezidakamizwa kanye nephrofayili yokukhishwa oyifunayo.

I-Biodegradable Polymers

-Ngakanani Izinhlelo zokulethwa kwezidakamizwa ezilondoloziwe Sebenzisa ama-viderhradable polymers afana ne-poly (i-lactic-co-glycolic acid) (i-plga) ne-poly (capacloractone) (PCL). Lawa ma-polymers anikela ngezinzuzo eziningana, kufaka phakathi i-biocomtic kanye nokuwohloka okulawulwayo, okuholela ekukhishweni kwezidakamizwa okubikezelayo. Kodwa-ke, izinselelo zihlala ekwenzeni kahle izakhiwo ze-polymer ukuthola izinhlelo ezithile zokulethwa kwezidakamizwa. Ukukhethwa kwe-polymer efanelekile kubalulekile ekufezekiseni ama-kinetics okukhululwa oyifunayo futhi unciphise imiphumela emibi.

Izicelo zokwelashwa kwezidakamizwa zokulethwa kwezidakamizwa

Ukwelashwa komdlavuza

Ukulethwa kwezidakamizwa okulondoloziwe Idlala indima enkulu ekwelashweni komdlavuza. Ngokuletha abenzeli be-chemotherapeapeutic esikhathini esengeziwe, le ndlela inciphisa imvamisa yokuphatha, inciphisa imiphumela emibi, futhi ithuthukise ukuhambisana nesiguli. Izibonelo zifaka amasistimu wokulethwa kwezidakamizwa afeziwe wokwelashwa kwe-tumor ehlelekayo kanye nama-nanoparticles wokulethwa kwezidakamizwa okuhlosiwe.

Ukwelashwa kweHormone Replacement

Ukwelashwa kwe-Hormone Replacement kuvame ukuzuzisa Izakhi zokulungiswa ezilondoloziwe. Lokhu kunciphisa ukuguquguquka kwamazinga we-hormone, okuholela ekusebenzeni kahle kanye nemiphumela emibi embalwa uma kuqhathaniswa nezindlela zokwelapha ezijwayelekile zomlomo noma ezifakayo. Lokhu kusebenza ikakhulukazi ekwelashweni okudinga amazinga we-hormone azinzile ngaphezulu kwezikhathi ezengeziwe.

Ezinye izinhlelo zokusebenza

Ngaphezu komdlavuza kanye nokwelashwa kwe-hormone esikhundleni sokwelashwa, Ukulethwa kwezidakamizwa okulondoloziwe isetshenziswa ezindaweni ezahlukahlukene zokwelapha, kufaka phakathi ukuphathwa kwezinhlungu (isb. Ukuguquguquka okuhlukahlukene kwale ndlela kwenza kube lula ukuthola izidingo ezahlukahlukene zokwelapha.

Izinzuzo kanye nokubi kwezidakamizwa ezilondoloziwe zokulethwa kwezidakamizwa

Ithebula elingezansi lifingqa izinzuzo ezisemqoka nasebubini be Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo:

Izikhombisi zesikhathi esizayo ekulethweni kwezidakamizwa ezilondoloziwe

Ucwaningo luyaqhubeka nokuthuthuka Ukwelashwa kokulethwa kwezidakamizwa okuqhubekayo. Izindawo zokugxila zifaka phakathi ukuthuthukiswa kwama-polyrmers amasha we-bioderlineble athuthukisiwe kanye namaphrofayili wokubonisa alawulwayo, ukuhlanganiswa kwezinhlelo zokuvuselela izidakamizwa ezibhekisisa izidakamizwa ezinikezwa izidakamizwa eziphendula izidakamizwa ezithile zemvelo.

Ukuthola eminye imininingwane ngocwaningo lomdlavuza kanye nezinketho zokwelashwa, cabanga ngokuvakashela i I-Shandong Baafa Cancer Research Institute Iwebhusayithi.

¹Idatha ingahluka ngokuya ngohlelo oluthile lwezidakamizwa nokulethwa okusetshenzisiwe. Sicela ubheke izincwadi ezifanele zesayensi kanye nemininingwane yomkhiqizo yedatha enemininingwane.