UkuKhupha okuZinzileyo koNyango loNikezelo lweziyobisi: Isishwankathelo esiBanzi 

UkuKhupha okuZinzileyo koNyango loNikezelo lweziyobisi: Isishwankathelo esiBanzi

Eli nqaku linika inkcazo eneenkcukacha Ukukhutshwa okuzinzileyo konyango lokuhanjiswa kweziyobisi, iphonononga iindlela zayo, izibonelelo, izicelo, kunye nezalathiso zexesha elizayo. Siza kukhangela kwiinkqubo ezahlukeneyo zokuhanjiswa, ukujongana neenzuzo kunye nokulinganiselwa kwazo, kunye nokuvavanya impembelelo kwiziphumo zesigulane kunye neendleko zonyango. Ulwazi olunikeziweyo lujoliswe kwabo bafuna ukuqonda okunzulu kule ndawo ebalulekileyo yophuhliso lwamayeza kunye nonyango.

IiNdlela zokuKhupha okuZinzileyo ukuhanjiswa kweziyobisi

IiNdlela zokuKhululwa eziLawulwayo

Ukukhululwa konyango lokunikezelwa kweziyobisi ixhomekeke kwiindlela ezahlukeneyo zokulawula umlinganiselo wokukhutshwa kwechiza emzimbeni. Ezi ziquka iinkqubo ezilawulwa yi-diffusion, apho iyeza lisasazeka nge-polymeric matrix; iinkqubo ezilawulwa ngokukhukuliseka, apho iyeza likhululwa njengoko i-polymer ithotywa; kunye neepompo ze-osmotic, ezisebenzisa uxinzelelo lwe-osmotic ukuqhuba ukukhutshwa kwechiza. Ukukhethwa kwendlela kuxhomekeke kwiipropati zeyeza kunye neprofayili efunwayo yokukhululwa.

Iipolymers zeBiodegradable

Abaninzi Ukukhutshwa okuzinzileyo kweenkqubo zokuhanjiswa kweziyobisi sebenzisa iipolima ezinokubola njengepoly(lactic-co-glycolic acid) (PLGA) kunye nepoly(caprolactone) (PCL). Ezi polymers zibonelela ngeenzuzo ezininzi, kubandakanya i-biocompatibility kunye nokuthotywa okulawulwayo, okukhokelela ekukhutshweni kweziyobisi okuqikelelweyo. Nangona kunjalo, imiceli mngeni ihleli ekuphuculeni iipropathi zepolymer kwizicelo ezithile zokuhanjiswa kweziyobisi. Ukukhethwa kwepolymer efanelekileyo kubalulekile ekufezekiseni i-kinetics yokukhupha efunwayo kunye nokunciphisa iziphumo ezinobungozi ezinokubakho.

Izicelo zoNyango oluZinzileyo loNikezelo lweziyobisi

Unyango lomhlaza

Ukuhanjiswa kweziyobisi okuzinzileyo idlala indima ebalulekileyo kunyango lomhlaza. Ngokuhambisa i-chemotherapeutic agents kwixesha elide, le ndlela inciphisa ukuphindaphinda kolawulo, inciphisa imiphumo emibi, kwaye iphucula ukuthotyelwa kwesigulane. Imizekelo ibandakanya iinkqubo zokuhanjiswa kweziyobisi ezifakelwayo kunyango lwethumba lwasekhaya kunye ne-nanoparticles ekunikezelweni kweziyobisi ekujoliswe kuzo.

Unyango loTshintsho lweHormone

Unyango lokubuyisela ihomoni ludla ngokuxhamla kulo ukukhutshwa okuzinzileyo kwemixube. Oku kunciphisa ukuguquguquka kumanqanaba ehomoni, okukhokelela ekusebenzeni okuphuculweyo kunye neziphumo ebezingalindelekanga ezimbalwa xa kuthelekiswa nonyango oluqhelekileyo lomlomo okanye olutofwayo. Oku kubaluleke kakhulu kunyango olufuna amanqanaba ehomoni azinzileyo kwixesha elide.

Ezinye ii-aplikeshini

Ngaphandle komhlaza kunye nonyango lokubuyisela ihomoni, ukukhutshwa okuzinzileyo kokunikezelwa kweziyobisi isetyenziswe kwiindawo ezahlukeneyo zonyango, kubandakanywa nokulawulwa kweentlungu (umzekelo, i-opioids eyandisiweyo), isifo senhliziyo (umzekelo, i-antihypertensive-release-release-release-antihypertensives), kunye ne-ophthalmology (umzekelo, amaconsi e-eye akhutshwa ngokuqhubekayo). Ukuguquguquka kwale ndlela kwenza ukuba ilungele uluhlu olubanzi lweemfuno zonyango.

Izinto eziluncedo kunye nezingeloncedo zokuhanjiswa kweziyobisi okuZinzileyo

Le theyibhile ingezantsi ishwankathela izinto eziluncedo nezingeloncedo Ukukhutshwa okuzinzileyo konyango lokuhanjiswa kweziyobisi:

Izalathiso zexesha elizayo kuKhupha oluZinzileyo loNikezo lweziyobisi

Uphando luqhubela phambili Ukukhutshwa okuzinzileyo konyango lokuhanjiswa kweziyobisi. Imimandla ekugxilwe kuyo ibandakanya ukuphuhliswa kweepolymer ezintsha ze-biodegradable kunye ne-biocompatibility ephuculweyo kunye neeprofayili ezilawulwayo zokuthotywa, ukudityaniswa kweendlela eziphambili zokujonga ukukhutshwa kwechiza kwi-vivo, kunye noyilo lweenkqubo zokuhanjiswa kweziyobisi eziphendulayo ezikhupha amachiza ekuphenduleni iimpawu ezithile zomzimba.

Ngolwazi oluthe kratya malunga nophando lomhlaza kunye neendlela zonyango, cinga ngokundwendwela IZiko loPhando ngoMhlaza laseShandong Baofa iwebhusayithi.

¹Idatha inokwahluka ngokuxhomekeke kwiyeza elithile kunye nenkqubo yokuhanjiswa esetyenzisiweyo. Nceda uqhagamshelane noncwadi lwenzululwazi olufanelekileyo kunye nolwazi lwemveliso ngedatha eneenkcukacha.