Ukuqonda amasistimu wokulethwa kwezidakamizwa okuhlosiwe 

Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza: Izinhlelo eziphelele zokulethwa kwezidakamizwa ezihlosiwe zihlose ukuletha kahle ama-ejenti wezokwelapha kumaseli anomdlavuza, ukunciphisa ukulimala kwezicubu ezinempilo. Le ndlela ithuthukisa kakhulu ukusebenza kwempilo futhi yehlise imiphumela emibi ehambisana ne-chemotherapy ejwayelekile. Lo mhlahlandlela uhlola izindlela ezahlukahlukene, izinzuzo, izinselelo namathuba esizayo we Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza.

Ukuqonda amasistimu wokulethwa kwezidakamizwa okuhlosiwe

Isidingo Sokunemba

I-chemotherapy evamile isabalalisa izidakamizwa zezi-anticancer emzimbeni wonke, okuholela kubuthi obuhlelekile. Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza, ngakolunye uhlangothi, ligxile ekuletheni i-ejenti yokwelapha ngokukhethekile kwisiza se-tumor, ngaleyo ndlela sinciphise imiphumela emibi futhi sithuthukise ukusebenza kwelashwa. Lokhu kutholakala ngokusebenzisa izinhlelo ezahlukahlukene zokuthwala eziqondise ngqo amaseli omdlavuza noma isimila se-microenvironments.

Izindlela zokuqondisa

Kusetshenziswa amasu amaningana ukufeza ukulethwa okuhlosiwe. Lokhu kufaka phakathi: Ama-antibono-izidakamizwa izidakamizwa: amasosha omzimba abopha ngokuqondile kumaseli we-tumor, alethe izidakamizwa ezinamathiselwe eCytotoxic ngqo kumaseli womdlavuza. Izibonelo zifaka i-trastuzumab emtansine (Kadcyla) yomdlavuza webele we-her2-positive and brentuximab vedotin (Adcetris) ye-hodgkin lymphoma. Okwengeziwe ucwaningo luyaqhubeka lube ngcono ukusebenza kahle kwe-ADC kanye nokunciphisa imiphumela ye-off-okuqondiwe. Ama-Liposomes: Lezi yi-vesicles yokufakelwa ehlanganisa umuthi. Zingashintshwa ngama-ligands okuhlosiwe ukuze athuthukise ukucaciswa kumaseli womdlavuza. I-Liposomal Doxorubicin (doxil) isibonelo esivamile, ikhombisa ukubekeka okuthuthukile ngokuqhathaniswa ne-Doxorubicin yamahhala. Ama-Nanoparticles: Ama-Nanoparticles, njenge-polymeric nanoparticles nama-nanoparticles we-inorganic, anikezela ukuguquguquka ekulayisheni kwezidakamizwa kanye namakhono okuqondisa. Ubukhulu bawo nobubanzi babo bungalinganiswa ukuthuthukisa ukunqwabelana kwesimila nokukhishwa kwezidakamizwa okulawulwayo. Ucwaningo ekusebenziseni ama-nanoparticles for Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza kuyanda futhi kufaka phakathi ukuhlola ama-polymers e-biodernerable kanye nama-nanoparticles aphendulayo. Amagciwane amagciwane: Amagciwane angahwebelana ukuletha izinto zofuzo, ezinjengezokwelapha zokwelapha noma amagciwane e-oncolytic, ikakhulukazi amaseli esigqwembe. Le ndlela iyahlolwa ngokwelashwa kweGene emdlavuza.

Izinzuzo nezinselelo

Izinzuzo zokulethwa kwezidakamizwa okuhlosiwe

Ukusebenza kwempumelelo: Ukuhlushwa kwezidakamizwa okuphezulu ngesiza se-tumor kuholela emiphumeleni yokwelashwa ethuthukisiwe. Ubuthi obuncishisiwe: Ukuvezwa okuncishisiwe kwezicubu ezinempilo ezidakamizweni kunciphisa imiphumela emibi. Ukutholwa kweziguli okuthuthukisiwe: Imiphumela emibi encishisiwe ingaholela ekubekezelelekeni okungcono kwesiguli kanye nokunamathela kumarejimevu wokwelashwa. Amathuba emithi enziwe ngezifiso: Ukuqondisa ama-subtypes athile omdlavuza noma ama-biomarkers avumela ukwelashwa okuhambisana nezenzo zenzelwe.

Izinselelo Ekunikezelweni Kwezidakamizwa Okuhlosiwe

I-Tumor Heterogeneity: Amaseli womdlavuza ngaphakathi kwesimila angabonisa izici ezihlukile, okwenza kube nzima ukuqondisa wonke amaseli ngempumelelo. Ukungena kwezidakamizwa: Ukufinyelela i-tumor core kungaba inselele ngenxa ye-stromag emfushane yezimoto. Ukuphendula amasosha omzimba: Uhlelo lokulethwa uqobo lungadala ukuphendula komzimba. Izindleko kanye nezinkinga zokukhiqiza: Ukuthuthukisa kanye nokukhiqiza izinhlelo ezihlosiwe zokulethwa kwezidakamizwa kungabiza.

Izikhombisi Zekusasa

Ucwaningo ngaphakathi Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza Ihlola ngenkuthalo izindlela ezithembisayo ezithembisayo, kufaka phakathi: izindlela zokwelapha: Ukuhlanganisa ukulethwa kwezidakamizwa okuhlosiwe nezinye izindlela zokwelapha umdlavuza, njengokusho kwe-immunotherapy noma ukwelashwa kwemisebe. Ama-ligands athuthukisiwe athuthukisiwe: athuthukisa ama-molecule asebenzayo futhi aqondile ahlosiwe. Ukukhishwa kwezidakamizwa okuphendulayo okuphendulayo: ukuklama izinhlelo zokulethwa ezikhipha izidakamizwa kuphela ekuphenduleni kokukhuthaza okuthile ngaphakathi kwe-tumor microenvelo. Inhlanganisela yezinhlelo ezahlukene zokulethwa: ukuhlanganisa izinzuzo zezinhlelo eziningi zomphumela we-synergistic.

Ukugcina

Ukulethwa kwezidakamizwa okuhlosiwe komdlavuza imelela intuthuko ebalulekile ekwelashweni komdlavuza. Ngenkathi izinselelo zihlala, ucwaningo oluqhubekayo nemizamo yentuthuko zibamba isithembiso esikhulu sokwenza ngcono ukusebenza kahle nokuphepha kokwelashwa komdlavuza. Ukuhlanganiswa kwamasu wokucabanga athuthukile kanye nokuqonda okuthuthukile kokuqonda i-tumology kubalulekile ukwenza kahle ukwakheka nokusetshenziswa kwalezi zinhlelo. Ngeminye imininingwane ngocwaningo lomdlavuza kanye nezinketho zokwelashwa, sicela uvakashele i-Shandong Bandong Baafa Cancer Research Institute Iwebhusayithi.The {ububanzi: 700px; Margin: 20px Auto; Umngcele-ukuwa kwe-Border: Ukuwa; th, TD {Border: 1px solid #ddd; I-Padding: 8px; I-Tex-Align: Kwesobunxele;} th {Umbala wesekeluzi: # F2F2F2;}