lapaʻau nui cell lung cancer lapaʻau

ʻO ka maʻi maʻi ʻaʻai ʻāʻī o ka maʻi maʻi maʻi ʻaʻole liʻiliʻi (NSCLC). Hoʻokomo pinepine ʻia nā ala lapaʻau i ka hui pū ʻana o ke ʻoki, chemotherapy, radiation therapy, targeted therapy, a me immunotherapy, i hoʻohālikelike ʻia i ke kūlana o kēlā me kēia maʻi, ke olakino holoʻokoʻa, a me nā ʻano kikoʻī kikoʻī. ʻO nā holomua hou i ka molecular profiling a me ka lāʻau lapaʻau pilikino e hoʻomaikaʻi i nā hopena no ka poʻe i loaʻa i ka LCLC. Understanding Large Cell Lung CancerWhat is Large Cell Lung Cancer?ʻO ka mālama ʻana i ka maʻi maʻi maʻi maʻi pūpū nui (LCLC) he 'ano o ka ma'i 'a'ai ma'i ma'i 'ole li'ili'i. Loaʻa kona inoa mai nā pūnaewele nui a ʻano ʻano like ʻole i ʻike ʻia ma lalo o kahi microscope. Hoʻomaka ka LCLC e ulu a laha koke, e hana koʻikoʻi ka maʻi a me ka mālama ʻana. ʻOiai ʻoi aku ka liʻiliʻi ma mua o nā ʻano NSCLC ʻē aʻe, ʻo ka hoʻomaopopo ʻana i kona mau hiʻohiʻona he mea nui ia no ka hoʻokele maikaʻi ʻana. ʻO nā kumu pilikia ʻē aʻe e pili ana i ka ʻike ʻana i ka uahi lua, radon, asbestos, a me kekahi mau mea ʻenehana. ʻO ka haʻalele ʻana i ka puhi paka, ka pale ʻana i ka ʻike ʻana i nā carcinogens i ʻike ʻia, a me ka mālama ʻana i ke ola olakino ʻo ia ka mea pale maikaʻi loa. ʻO ka nānā mau ʻana a me ka nānā ʻana i ka maʻi kanesa maʻi no nā poʻe koʻikoʻi hiki ke kōkua i ka ʻike mua ʻana a hiki ke hoʻomaikaʻi. ka lapaʻau ʻana i ka maʻi maʻi ʻaʻai nui hualoaʻa.Nā Koho Lapaʻau no ka Large Cell Lung CancerSurgery ʻO ke kaʻina hana ka lālani mua o ka lāʻau lapaʻau no ka LCLC i ka wā mua, ke ʻike ʻia ka ʻōpū a ʻaʻole i laha i nā wahi mamao. Hiki i ke kaʻina hana ke hoʻoneʻe i kahi ʻāpana o ke akemāmā (wedge resection or segmentectomy), he lobe holoʻokoʻa (lobectomy), a i ʻole ke akemāmā holoʻokoʻa (pneumonectomy). ʻO ke koho ʻana o ka ʻoki ʻana ma muli o ka nui a me kahi o ka ʻōpū, a me ka hana holoʻokoʻa o ka mea maʻi. ʻO Shandong Baofa Cancer Research Institute ua ʻike nui ʻia i kēia mau kaʻina hana. Hoʻohana pinepine ʻia me ka ʻoki ʻana a i ʻole ka radiation therapy, a i ʻole ma ke ʻano he lapaʻau mua no ka LCLC pae kiʻekiʻe. ʻO nā papa hana chemotherapy maʻamau no ka LCLC he mau lāʻau lapaʻau-platinum (e like me cisplatin a i ʻole carboplatin) i hui pū ʻia me nā lāʻau lapaʻau ʻē aʻe. Hiki i nā hopena ʻaoʻao o ka chemotherapy ke komo i ka nausea, ka luhi, ka lauoho lauoho, a me ka nui o ka pilikia o ka maʻi. Hiki ke hoʻohana ʻia no ka mālama ʻana i ka LCLC ma nā ʻano like ʻole: ma ke ʻano he lapaʻau mua no nā poʻe maʻi ʻaʻole i moho no ke oki ʻana, ma ke ʻano he lapaʻau adjuvant ma hope o ke kaʻe ʻana e pepehi i nā keʻena maʻi kanesa i koe, a i ʻole e hōʻoluʻolu i nā hōʻailona e like me ka ʻeha a i ʻole ka pōkole o ka hanu i ka maʻi pae kiʻekiʻe. ʻO nā ʻano o ka lāʻau lapaʻau i hoʻohana ʻia no ka LCLC ʻo ia ka lāʻau lapaʻau lāʻau lāʻau waho (EBRT) a me ka stereotactic body radiation therapy (SBRT). He mea maikaʻi loa kēia mau lāʻau lapaʻau no nā poʻe maʻi me nā hoʻololi genetic kikoʻī i ko lākou mau maʻi koko. ʻO nā pahuhopu maʻamau i ka LCLC ka EGFR, ALK, ROS1, a me BRAF. Ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau i hoʻopaʻa ʻia, hoʻomaʻamaʻa maʻamau nā mea maʻi i ka hoʻāʻo molecular e hoʻoholo ai inā loaʻa i kā lākou maʻi koko kekahi o kēia mau mutation hiki ke hana. Inā makemake ʻoe i ke kōkua, hiki i ka Baofa Cancer Research Institute ke hāʻawi i nā lawelawe hoʻāʻo genetic.ImmunotherapyImmunotherapy hoʻohana i ka mana o ke kino ponoʻī o ke kino e hakakā i ka maʻi kanesa. ʻO nā mea hoʻopaʻapaʻa hoʻopaʻa palekana, e like me pembrolizumab, nivolumab, a me atezolizumab, he ʻano o ka immunotherapy e pale ai i nā protein e pale ai i ka ʻōnaehana pale mai ka hoʻouka ʻana i nā maʻi kanesa. Ua hōʻike ka Immunotherapy i nā hopena maikaʻi loa i ka mālama ʻana i ka LCLC, ʻoi aku ka nui o nā maʻi i hōʻike ʻia nā maʻi koko i nā pae kiʻekiʻe o PD-L1. Hiki ke hoʻohana ʻia ma ke ʻano he lāʻau lapaʻau mua no ka LCLC pae kiʻekiʻe a i ʻole ma hope o ka hāʻule ʻana o ka chemotherapy. ʻO nā holomua i ka Large Cell Lung Cancer TreatmentMolecular ProfilingMolecular profiling e pili ana i ke kālailai ʻana i ka ʻiʻo tumo o ka mea maʻi e ʻike ai i nā hoʻololi genetic kikoʻī a i ʻole nā ​​hoʻololi molekala ʻē aʻe e alakaʻi i ka ulu ʻana o ka maʻi kanesa. Hiki i kēia ʻike ke kōkua i nā kauka e koho i ka lāʻau lapaʻau kūpono a i ʻole immunotherapy no kēlā me kēia maʻi. He ʻano hana maʻamau ka hoʻopaʻa ʻana o ka hanauna hou (NGS) i hoʻohana ʻia no ka molecular profiling, e ʻae ana i ka ʻike like ʻana o nā hoʻololi genetic lehulehu. ka lapaʻau ʻana i ka maʻi maʻi ʻaʻai nui i ka mea maʻi e pili ana i ka molecular profile o lākou, ke olakino holoʻokoʻa, a me nā makemake. Ke manaʻo nei kēia ala e hoʻonui i ka maikaʻi o ka mālama ʻana me ka hōʻemi ʻana i nā hopena ʻaoʻao. Ke ulu nui nei ka lāʻau lapaʻau pilikino i ka mālama ʻana i ka LCLC, no ka mea, hiki i nā kauka ke koho i ka hoʻolālā lapaʻau kūpono loa no kēlā me kēia maʻi. ʻO ke komo ʻana i kahi hoʻokolohua lapaʻau hiki ke hāʻawi i nā poʻe maʻi i ke komo ʻana i nā lāʻau lapaʻau ʻokiʻoki ʻaʻole i loaʻa ākea. He ʻāpana koʻikoʻi nā hoʻokolohua lapaʻau no ka holomua ʻana i ka mālama ʻana i ka maʻi kanesa, a pono nā mea maʻi e kūkākūkā me kā lākou mau kauka inā he koho maikaʻi ia no lākou ke komo ʻana i kahi hoʻokolohua lapaʻau. ʻOi aku ka maikaʻi o ka wānana mua o ka LCLC pae mua i mālama ʻia me ka ʻoki ʻana ma mua o ka LCLC pae kiʻekiʻe i laha i nā wahi mamao. ʻO nā holomua o ka lapaʻau ʻana, e like me ka hoʻomaʻamaʻa ʻia a me ka immunotherapy, ua hoʻomaikaʻi i nā helu ola no nā maʻi me LCLC i nā makahiki i hala. 5 Makahiki Ola Ola no ka Non-Small Cell Lung Cancer (NSCLC) ma ka Stage1 Stage 5-Year Survival Rate Localized 63% Regional 36% Distant 8% All SEER Stage 26% *Note: Hoʻokumu ʻia kēia mau helu ola ma ka ʻikepili mai ka National Cancer Institute's Surveillance, Epidemiology, Large Cell Results. me LCLC hiki ke paʻakikī, akā aia nā kumuwaiwai e kōkua i nā maʻi a me ko lākou mau ʻohana e hoʻokō i nā hopena kino a me nā manaʻo o ka maʻi. Hiki i nā hui kākoʻo, ka ʻōlelo aʻo, a me ka mālama palliative ke hāʻawi i ke kōkua koʻikoʻi. ʻO ka mālama ʻana i ke ola olakino, me ka ʻai kaulike a me ka hoʻoikaika mau, hiki ke hoʻomaikaʻi i ka maikaʻi o ke ola. He mea nui ke kūkākūkā ʻana i nā pilikia a me nā nīnau me kāu hui mālama ola no ka hoʻokele pono ʻana i ka LCLC. ʻImi ʻana i ke kākoʻo a me nā kumuwaiwai. Aia kēia mau kumuwaiwai i nā mea hoʻonaʻauao, nā hui kākoʻo, nā papahana kōkua kālā, a me nā hoʻoikaika ʻōlelo. Hiki i ka pilina ʻana me kēia mau kumuwaiwai ke hāʻawi i ke kākoʻo koʻikoʻi a me ke alakaʻi ʻana i ka huakaʻi maʻi maʻi.Kuhikuhi: American Society of Clinical Oncology (ASCO): Lung Cancer - Non-Small Cell: Heluhelu.