unyango olutsha lomhlaza wedlala lobudoda unyango lwemitha yemitha

Imitha yolwelo, ekwaziwa njengonyango lwe-radiopharmaceutical, luvela njengoluthembisayo unyango ukhetho lwenkqubela phambili umhlaza wedlala lesinyi. Le ndlela yenkqubo ihambisa imitha ekujoliswe kuyo ngokuthe ngqo kwiiseli zomhlaza kuwo wonke umzimba, ibonelela ngeenzuzo ezinokubakho ngaphezulu kwemitha yemitha yangaphandle. Unyango lusebenzisa i-isotopes ene-radioactive encanyathiselwe kwiimolekyuli ezizibophelela ngokukhethiweyo umhlaza wedlala lesinyi iiseli, ukunciphisa umonakalo kwizicubu eziphilileyo.Yintoni Imitha yolwelo Unyango lwe Umhlaza weProstate?Imitha yolwelo Unyango, olukwabizwa ngokuba lunyango lwe-radiopharmaceutical okanye i-systemic radiation, lusebenzisa amayeza e-radioactive afakwa emithanjeni. La machiza ajikeleza kuwo wonke umzimba kwaye ajolise ngokukhethekileyo kwiiseli zomhlaza, ehambisa imitha ngokuthe ngqo kuzo. Le ndlela inika indlela yokufikelela kwiiseli zomhlaza ezinokuthi zisasazeke ngaphaya kwe-prostate gland, okwenza kube yinto enokwenzeka unyango ngenxa ye-metastatic umhlaza wedlala lesinyi. Nge IZiko loPhando ngoMhlaza laseShandong Baofa, senza uphando ngokuqhubekayo kwaye sisulungekisa ukusetyenziswa konyango olunjalo.Isebenza Njani? Inkqubo ibandakanya ukuqhotyoshela isotopu ye-radioactive kwi-molecule ekujoliswe kuyo. Le molekyuli ifuna kwaye ibophelele kwiiprotheni ezithile okanye i-receptors efunyenwe kuyo umhlaza wedlala lesinyi iiseli. Nje ukuba iyeza lilawulwe, lihamba egazini, lifumane iiseli zomhlaza, kwaye lizise idosi yendawo yemitha, itshabalalisa iiseli zomhlaza ngelixa inciphisa umonakalo kwizihlunu ezisempilweni ezingqongileyo. Yicinge nje ngomjukujelwa okhokelwayo ojolise kutshaba kuphela Umhlaza weProstate Izigulana zinokuzuza kwi Imitha yolwelo?Imitha yolwelo isetyenziswa ikakhulu kwizigulane ezihambele phambili umhlaza wedlala lesinyi ethe yanwenwela kwamanye amalungu omzimba (metastatic umhlaza wedlala lesinyi), ngakumbi xa ezinye unyango iinketho ezifana nonyango lwehomoni kunye nechemotherapy azisasebenzi. Ihlala ithathelwa ingqalelo kwizigulane ezine-cancer ezivakalisa iithagethi ezithile, ezifana ne-PSMA (i-prostate-specific membrane antigen) .Ifumanekayo Unyango ngemitha yolwelo ngenxa Umhlaza weProstateAbaliqela imitha yolwelo amayeza akhoyo okanye aphantsi kophuhliso lokunyanga umhlaza wedlala lesinyi. Nazi ezinye zezona zibalaseleyo:I-Lutetium-177 PSMA TherapyLutetium-177 PSMA (177Lu-PSMA) yenye yezona zisetyenziswa kakhulu kwaye zafundwa unyango ngemitha yolwelo ngenxa umhlaza wedlala lesinyi. I-PSMA yiprotheyini efumaneka kwiindawo eziphakamileyo eziphezulu kumphezulu wobuninzi umhlaza wedlala lesinyi iiseli. I-177Lu-PSMA iqulethe i-isotope ye-radioactive Lutetium-177 eqhotyoshelwe kwi-molecule ebophelela kwi-PSMA. Oku kuvumela ukusasazeka kwemitha ukuba kuhanjiswe ngokuthe ngqo kwiiseli zomhlaza ezibonisa i-PSMA. Uphononongo lubonise izibonelelo ezibalulekileyo malunga nokuphila kunye nomgangatho wobomi kwizigulane eziphathwa nge-177Lu-PSMA emva kokuba ezinye iindlela zonyango zihlulekile. KwiZiko loPhando loMhlaza laseShandong Baofa, uphando lwethu lujolise ekuphuculeni ukusebenza kakuhle nokunciphisa iziphumo ebezingalindelekanga zolu nyango lujoliswe kuko.IRadium-223 Dichloride (Xofigo)Radium-223 dichloride, ethengiswa njengeXofigo, yenye unyango ngemitha yolwelo isetyenziselwa ukwenza i-metastatic umhlaza wedlala lesinyi elithe lanwenwela emathanjeni, kodwa aliphumela kwamanye amalungu. I-Radium-223 ilinganisa i-calcium kwaye ikhethwa ngokukhethiweyo ngamathambo, ngokukodwa kwiindawo apho umhlaza wonakalise ithambo. Imitha ekhutshwa yiRadium-223 itshabalalisa iiseli zomhlaza ethanjeni, inceda ekuthomalaliseni iintlungu nokuphucula ukuphila. Imitha yolwelo ngenxa Umhlaza weProstateImitha yolwelo inikeza iingenelo ezininzi ezinokuthi zibe kho ngaphezu kwemveli unyango iindlela: Unyango olujolisiweyo: Ngokukhethekileyo ijolise kwiiseli zomhlaza, ukunciphisa umonakalo kwizicubu eziphilileyo. Indlela Yenkqubo: Inokufikelela kwiiseli zomhlaza ezithe zasasazeka kuwo wonke umzimba. Umgangatho woBomi obuphuculweyo: Unokunciphisa iimpawu kunye nokuphucula umgangatho wobomi bonke kwizigulana eziphambili umhlaza wedlala lesinyi. Ukubanakho Ukusinda ixesha elide: Uphando luye lwabonisa ukuba imitha yolwelo inokwandisa ukusinda kwezinye izigulana.Iziphumo ebezingalindelekanga ezinokwenzeka ze Unyango lwemitha yolweloNjengawo wonke umhlaza unyango, imitha yolwelo kunokubangela iziphumo ebezingalindelekanga. Iziphumo ezithile ebezingalindelekanga zixhomekeke kuhlobo lwechiza le-radioactive elisetyenzisiweyo kunye nesigulane ngasinye. Iziphumo ebezingalindelekanga eziqhelekileyo zibandakanya: Ukudinwa Isicaphucaphu Ukucinezelwa komongo wethambo (okukhokelela ekubalweni kweeseli zegazi ezisezantsi) Umlomo owomileyo Ugqirha wakho uya kukubeka esweni ngononophelo ngeziphumo ebezingalindelekanga kwaye akunike ukhathalelo oluxhasayo ukuze uzilawule.Yintoni onokuyilindela Ngexesha Unyango lwemitha yolweloI unyango Inkqubo ibandakanya: Ukudibana kokuqala kunye ne-oncologist yakho ukufumanisa ukuba imitha yolwelo ifanelekile kuwe. Ukujonga izikena zokuvavanya ubungakanani bomhlaza wakho kwaye ufumanise ukuba uyaluchaza na ujoliso lwechiza le-radioactive. Ukulawulwa kweyeza le-radioactive ngemithambo. Ukuqeshwa rhoqo kokulandelela ukujonga impendulo yakho unyango kwaye ulawule naziphi na iziphumo ebezingalindelekanga.Ikamva le Imitha yolwelo kwi Unyango lweProstate CancerIntsimi ye imitha yolwelo ngenxa umhlaza wedlala lesinyi ikhula ngokukhawuleza. Abaphandi baphuhlisa amachiza amatsha e-radioactive ajolise kwiimolekyuli ezahlukeneyo kwiiseli zomhlaza, kunye nezicwangciso zokudibanisa imitha yolwelo nabanye unyango, ezifana ne-immunotherapy kunye ne-hormone therapy. Injongo kukuphucula ngakumbi ukusebenza kakuhle kwe unyango kunye nokwandisa ixesha lokuphila kwizigulane ezihambele phambili umhlaza wedlala lesinyi. Siyakumema ukuba uqhagamshelane neShandong Baofa Cancer Research Institute ukuze ufunde ngakumbi ngamagalelo ethu kulo mmandla unika umdla.Ukuthelekisa okwahlukileyo Unyango ngemitha yolweloUthelekiso olulula lwezimbini eziphambili unyango ngemitha yolwelo ekhoyo umhlaza wedlala lesinyi: Unyango ekujoliswe kuyo Ukusetyenziswa kweempembelelo eziPhambili zeLutetium-177 PSMA (177Lu-PSMA) i-PSMA (i-Prostate-Specific Membrane Antigen) i-Metastatic Umhlaza weProstate (Emva kokusilela kolunye unyango) Ukudinwa, umlomo owomileyo, isicaphucaphu, ukucinezelwa umongo wethambo iRadium-223 Dichloride (Xofigo) Ithambo (Mimics Calcium) Metastatic Umhlaza weProstate ukuya ethanjeni Isicaphucaphu, ukugabha, intlungu yamathambo, ukucinezelwa komongo I-Disclaimer: Le theyibhile ibonelela ngoshwankathelo olulula kwaye akufuneki isetyenziswe endaweni yeengcebiso zobugqirha. Qhagamshelana nomboneleli wakho wezempilo ukuze ufumane isikhokelo somntu.Ngaba Imitha yolwelo Ilungelo Kuwe?Ukuba uhambele phambili umhlaza wedlala lesinyi kwaye banomdla wokufunda ngakumbi malunga imitha yolwelo, thetha nooncologist wakho. Banokuyiphonononga imeko yakho kwaye babone ukuba ngaba oku unyango ukhetho lufanelekile kuwe.IiReferensi:[1] Iziko lomhlaza leSizwe. https://www.cancer.gov/