Nā kumu o ka maʻi maʻi pancreatic: ka hoʻomaopopo ʻana i nā kumu pilikia 

Hoʻoholo pololei nā kumu maʻi maʻi pancreatic he paʻakikī, akā ua ʻike ka noiʻi i kekahi mau mea pilikia e hiki ke hoʻonui i ka hiki ke ulu i kēia maʻi. Loaʻa kēia mau mea mai nā genetic predispositions a me nā koho ʻana i ke ʻano o ke ola i nā kūlana olakino mua. Hāʻawi kēia ʻatikala i kahi ʻike piha o kēia mau kumu kūpono, hāʻawi i nā ʻike waiwai i ka hoʻomaopopo ʻana a me ka hoʻēmi ʻana i kou pilikia.

He aha ka maʻi maʻi pancreatic?

ʻO ka maʻi ʻaʻai pancreatic He maʻi ia e hoʻokumu ʻia ai nā ʻiʻo ʻino i loko o nā ʻiʻo o ka pancreas, kahi okana ma hope o ka ʻōpū. Hoʻopuka ka pancreas i nā enzymes e kōkua i ka ʻeli ʻana i ka meaʻai a me nā hormones e kōkua i ka hoʻoponopono ʻana i ke kō koko. ʻElua ʻano nui o ka maʻi ʻaʻai pancreatic: adenocarcinoma, e hoʻomaka ana i loko o nā sela e laina ana i nā ʻauwaʻa o ka pancreas, a me nā ʻōpū neuroendocrine, ʻaʻole i maʻamau a ala mai nā pūnaewele hoʻohua o ka pancreas.

Hoʻokumu ʻia ʻO nā kumu maʻi maʻi pancreatic a me nā mea pilikia

Hoʻohālikelike Genetic

He pākēneka liʻiliʻi o maʻi ʻaʻai pancreatic pili nā hihia i nā hoʻololi genetic hoʻoilina. Hiki i kēia mau hoʻololi ke hoʻonui i ka maʻalahi o ke kanaka e hoʻomohala i ka maʻi. ʻO kekahi o nā genes e pili ana i ka piʻi ʻana o ka pilikia:

• BRCA1 a me BRCA2: Hoʻopili pū ʻia kēia mau genes i ka maʻi maʻi umauma a me ka ovarian.
• PALB2: Hana kēia gene me BRCA2 e hoʻoponopono i ka DNA i poino.
• ATM: Hoʻopili kēia gene i ka hoʻoponopono DNA a me ka mālama ʻana i ka pōʻai cell.
• Nā genes Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM): Hoʻonui kēia maʻi i ka nui o nā maʻi maʻi maʻi, me ka maʻi maʻi pancreatic.
• p16/CDKN2A: Kōkua kēia gene i ka hoʻoponopono ʻana i ka ulu ʻana o nā cell.
• STK11: Hoʻopili ʻia me ka maʻi Peutz-Jeghers, kahi e hoʻoulu ai i nā polyps i loko o ka digestive tract a hoʻonui i ka maʻi kanesa.

Nā Kūlana Ola

Hiki i kekahi mau koho ola ke hoʻopilikia nui i kou pilikia o ka ulu ʻana maʻi ʻaʻai pancreatic:

• Puhi: ʻO ka puhi paka kekahi o nā kumu pilikia nui loa no maʻi ʻaʻai pancreatic. ʻO ka poʻe puhi paka he ʻelua a ʻekolu mau manawa e ulu ai ka maʻi ma mua o ka poʻe ʻaʻole puhi. ʻO ka haʻalele ʻana i ka puhi paka hiki ke hōʻemi i kou pilikia i ka manawa.
• ʻObesity: ʻO ka lilo ʻana i ka momona a i ʻole ka momona, ʻoi aku ka nui o ka momona o ka ʻōpū, pili i ka piʻi nui o ka maʻi ʻaʻai pancreatic. He mea koʻikoʻi ka mālama ʻana i ke kaumaha olakino ma o ka ʻai a me ka hoʻoikaika kino.
• ʻAi: ʻO ka ʻai ʻana i nā ʻiʻo ʻulaʻula a me nā ʻiʻo i hana ʻia a haʻahaʻa i nā huaʻai a me nā lau ʻai hiki ke hoʻonui i ka pilikia. E noʻonoʻo i ka meaʻai kaulike i loaʻa i ka palaoa piha, ka protein lean, nā huaʻai, a me nā mea kanu.
• ʻAi ʻona: ʻO ka inu nui ʻana i ka waiʻona, ʻoi loa ke hui pū ʻia me ka puhi paka, ua pili pū me ka piʻi ʻana o ka pilikia.

Nā Kūlana Lapaʻau

Hiki i kekahi mau maʻi maʻi ke hoʻokiʻekiʻe i ka pilikia o maʻi ʻaʻai pancreatic:

• Diabetes: ʻO ka maʻi diabetes lōʻihi, ʻo ia hoʻi ka maʻi diabetes type 2, pili i kahi pilikia kiʻekiʻe. Inā he kumu a he hōʻailona mua paha ka maʻi diabetes maʻi ʻaʻai pancreatic ke hoʻokolokolo ʻia nei.
• ʻO ka maʻi pancreatitis mau loa: Hiki i ka mumū lōʻihi o ka pancreas ke hoʻonui i ka pilikia, ʻoi aku ka nui o nā poʻe me ka pancreatitis hereditary.
• Moʻolelo ʻohana: He moʻolelo ʻohana o maʻi ʻaʻai pancreatic hoʻonui i kou pilikia, ʻoi aku ka nui o nā ʻohana pili i hoʻopilikia ʻia. Hōʻike paha kēia i ka loaʻa ʻana o nā hoʻololi genetic hoʻoilina.
• makahiki: Ka pilikia o maʻi ʻaʻai pancreatic piʻi me ka makahiki. ʻO ka hapa nui o nā hihia i ʻike ʻia i nā poʻe ma luna o 65 mau makahiki.
• Lahui: ʻOi aku ka nui o ka pilikia o ka ulu ʻana o nā ʻAmelika ʻAmelika maʻi ʻaʻai pancreatic hoʻohālikelike ʻia me nā Caucasians. ʻAʻole maopopo loa nā kumu o kēia ʻokoʻa akā pili paha nā kumu genetic, socioeconomic, a me ka nohona.

ʻO nā kumu pilikia maʻamau

ʻOiai ʻaʻole maʻamau, hiki i kēia mau mea ke kōkua i ka hoʻomohala ʻana o maʻi ʻaʻai pancreatic:

• ʻIke i kekahi mau mea kemika: Hiki ke hoʻonui i ka pōʻino i ka loaʻa ʻana o kekahi mau lāʻau pesticides, nā waiʻula, a me nā kinikona i hoʻohana ʻia i ka hana metala.
• Helicobacter pylori (H. pylori) ma'i: Hōʻike kekahi mau haʻawina i kahi pilina ma waena H. pylori ka maʻi, hiki ke hoʻoulu i ka ʻōpū o ka ʻōpū, a me ka piʻi nui ʻana o ka maʻi ʻaʻai pancreatic.
• ʻO ka maʻi cirrhosis: ʻO ka Cirrhosis, a i ʻole ka ʻili ʻana o ke ake, hiki ke hoʻonui i ka pilikia.

Hiki Ka maʻi maʻi ʻaʻai pancreatic Kāohi ʻia?

ʻOiai ʻaʻohe ala paʻa e pale ai maʻi ʻaʻai pancreatic, hiki iā ʻoe ke hana i nā hana e hōʻemi ai i kou pilikia ma ka nānā ʻana i nā mea pilikia hiki ke hoʻololi ʻia:

• Ha'alele i ka puhi paka: ʻO kēia ka mea nui loa āu e hana ai e hōʻemi i kou pilikia.
• E mālama i ke kaumaha olakino: E ʻai i ka meaʻai kaulike a hoʻoikaika mau i ka mālama ʻana i ke kaumaha olakino.
• E kaupalena i ka inu ʻana i ka waiʻona: Inā inu ʻoe i ka waiʻona, e hana maʻalahi.
• Mālama i ka maʻi diabetes: E hana pū me kāu kauka e mālama pono i kāu maʻi diabetes.
• E noʻonoʻo i ka ʻōlelo aʻoaʻo Genetic: Inā he moʻolelo ʻohana ikaika ʻoe o maʻi ʻaʻai pancreatic a i ʻole nā maʻi maʻi e pili ana, e noʻonoʻo i ka ʻōlelo aʻoaʻo genetic e loiloi i kou pilikia.

Noiʻi a me ka hana hou ma Shandong Baofa Cancer Research Institute

Ma ka Shandong Baofa Cancer Research Institute, ua hoʻolaʻa mākou i ka holomua ʻana i ka ʻike a me ka mālama ʻana i nā maʻi maʻi maʻi, me maʻi ʻaʻai pancreatic. Hoʻokumu kā mākou noiʻi i ka ʻike ʻana i nā pahuhopu therapeutic novel, hoʻomohala i nā mea hana diagnostic hou, a me ka hoʻomaikaʻi ʻana i nā hopena maʻi. Hoʻopaʻa mākou i ka unuhi ʻana i ka noiʻi ʻokiʻoki i nā noi kūpono e pono ai nā poʻe maʻi ma ka honua holoʻokoʻa. Ke hana luhi nei kā mākou hui loea e ʻimi i ka paʻakikī o ka biology cancer a hoʻomohala i nā lāʻau lapaʻau maikaʻi loa no kēia maʻi paʻakikī. Manaʻo mākou ma o ka noiʻi ʻana a me ka hoʻolaʻa ʻana i ka hana hou, hiki iā mākou ke hana i kahi hopena koʻikoʻi i ka hakakā ʻana maʻi ʻaʻai pancreatic.

Ka hoomaopopo ana i kou pilikia a me ka imi ana i ka Lapaau

He mea nui e hoʻomanaʻo i ka loaʻa ʻana o hoʻokahi a ʻoi aʻe paha nā kumu pilikia ʻaʻole ia he manaʻo e ulu maoli ʻoe maʻi ʻaʻai pancreatic. ʻAʻole loaʻa ka maʻi i ka nui o nā poʻe me nā kumu pilikia, aʻo nā poʻe ʻē aʻe me nā kumu pilikia ʻike ʻole. Inā hopohopo ʻoe i kou pilikia, e kamaʻilio me kāu kauka. Hiki iā lākou ke loiloi i kāu mau pilikia pilikino a hōʻike i nā hoʻolālā nānā ʻana a nānā ʻana paha. He mea koʻikoʻi ka ʻike mua a me ka hōʻoia ʻana no ka hoʻomaikaʻi ʻana i nā hopena ma maʻi ʻaʻai pancreatic lapaʻau.

Nā Hana Hoʻomaʻamaʻa

ʻIke mua o maʻi ʻaʻai pancreatic he mea koʻikoʻi no ka hoʻomaikaʻi ʻana i nā hopena lapaʻau. Hoʻohana ʻia kekahi mau ala diagnostic e ʻike a hoʻopaʻa i ka maʻi:

• Nā hoʻāʻo kiʻi:
  • CT Scan Hāʻawi i nā kiʻi kikoʻī kikoʻī o ka pancreas a me nā ʻāpana a puni, e kōkua ana i ka ʻike ʻana i nā ʻōpū.
  • MRI Hoʻohana i nā māla magnetic a me nā hawewe lekiō e hana i nā kiʻi kikoʻī o ka pancreas a hiki ke hoʻohana pono i ka ʻike ʻana i nā ʻōpū liʻiliʻi.
  • Endoscopic Ultrasound (EUS): Hoʻopili ʻia ka hoʻokomo ʻana i kahi paipu lahilahi a maʻalahi me kahi ʻimi ultrasound i hoʻopili ʻia i loko o ka esophagus e ʻike ai i ka pancreas. Hiki ke hoʻohana ʻia ʻo EUS e hōʻiliʻili i nā laʻana kiko no ka biopsy.
  • PET Scan (Positron Emission Tomography): Hoʻohana pinepine ʻia me ka CT scan e ʻike i nā maʻi maʻi a puni ke kino.
• Biopsy:
  • ʻO ka manaʻo o ka nila maikaʻi (FNA): Hoʻokomo ʻia kahi nila lahilahi i loko o ka pancreas e hōʻiliʻili i nā cell no ka nānā ʻana.
  • ʻO ka biopsy ʻokiʻoki: Hoʻopili i ka wehe ʻana i kahi laʻana kiko mai ka pancreas no ka nānā ʻana. Hana ʻia kēia inā ʻaʻole hiki ke hana ʻia nā ala ʻē aʻe.
• Nā hoʻāʻo koko:
  • Hōʻailona Tumor: Hoʻokiʻekiʻe ʻia kekahi mau mea, e like me CA 19-9 i kekahi poʻe me maʻi ʻaʻai pancreatic. Eia naʻe, ʻaʻole pololei kēia mau māka a hoʻohana pinepine ʻia me nā hoʻokolohua diagnostic ʻē aʻe.

Nā koho lapaʻau

Lapaʻau no maʻi ʻaʻai pancreatic pili i ke kahua a me kahi o ka maʻi kanesa, a me ke olakino holoʻokoʻa o ka mea maʻi. Loaʻa nā koho lapaʻau maʻamau:

• ʻO ka ʻoki ʻana:
  • ʻO ke kaʻina hana Whipple (Pancreaticoduodenectomy): Hoʻopili i ka wehe ʻana i ke poʻo o ka pancreas, kahi hapa o ka ʻōpū liʻiliʻi, ka gallbladder, a me kahi hapa o ka ʻōpū.
  • ʻO ka maʻi pancreatectomy: Ka wehe ʻana i ka huelo a me ka ʻāpana o ke kino o ka pancreas.
  • Huina Pancreatectomy: Ka wehe ʻana o ka pancreas holoʻokoʻa. He mea maʻamau kēia akā pono paha i kekahi mau hihia.
• Kemoterapi:
  • Hoʻohana i nā lāʻau lapaʻau e pepehi i nā maʻi maʻi a i ʻole e hoʻolōʻihi i ko lākou ulu ʻana. Hiki ke hoʻohana ʻia ke kemoterapi ma mua a ma hope paha o ka ʻoki ʻana, a ma ke ʻano he lāʻau lapaʻau mua inā ʻaʻole he koho.
• Lapaʻau Radiation:
  • Hoʻohana i nā kukuna ikaika nui e pepehi i nā maʻi maʻi maʻi. Hiki ke hoʻohana ʻia ka lāʻau lapaʻau ma mua a ma hope paha o ka ʻoki ʻana, a ma ke ʻano he lāʻau lapaʻau mua.
• ʻO ka lāʻau lapaʻau i koho ʻia:
  • Hoʻohana i nā lāʻau lapaʻau e hoʻopaʻa i nā molekole kikoʻī e pili ana i ka ulu ʻana o ka cell cancer a me ke ola.
• Immunotherapy:
  • Kōkua i ke kino o ke kino e hakakā i nā maʻi maʻi. ʻAʻole hoʻohana pinepine ʻia ka Immunotherapy no maʻi ʻaʻai pancreatic akā he koho paha i kekahi mau hihia.

Uku Ola

Ka helu ola no maʻi ʻaʻai pancreatic ʻokoʻa ma muli o ke kahua o ka maʻi maʻi a me ka lāʻau i loaʻa. He mea koʻikoʻi ka ʻike mua ʻana a me ka mālama ʻana no ka hoʻomaikaʻi ʻana i nā hopena ola. Wahi a ka American Cancer Society, ʻo ka helu ola 5 makahiki no ka localized maʻi ʻaʻai pancreatic (ʻo ka maʻi kanesa ʻaʻole i laha ma waho o ka pancreas) ma kahi o 44%. Eia naʻe, ma kahi o 12% wale nō maʻi ʻaʻai pancreatic ʻike ʻia nā hihia ma kēia pae. No ka ma'i 'a'ai i laha i nā kino a i 'ole nā'iu kokoke, 'o ka 5 makahiki ola ola ma kahi o 12%. No ka ma'i 'a'ai i laha i na wahi mamao o ke kino, he 3% ka nui o ke ola 5 makahiki. Hoʻonui ka maʻi maʻi mua ma Shandong Baofa Cancer Research Institute i ka helu ola.

He helu kēia mau helu a hiki ke ʻokoʻa ma muli o ke kūlana o kēlā me kēia kanaka. He mea nui e kūkākūkā i kāu prognosis me kāu kauka e hoʻomaopopo i kou kūlana kikoʻī.

Noiʻi mau

Ke hana mau nei nā mea noiʻi e hoʻomaikaʻi i ka ʻike a me ka mālama ʻana o maʻi ʻaʻai pancreatic. ʻO nā wahi o ka noiʻi e hoʻomau nei:

• Ka hoʻomohala ʻana i nā lāʻau lapaʻau hou a ʻoi aku ka maikaʻi, me nā lāʻau lapaʻau i hoʻopaʻa ʻia a me nā immunotherapies.
• Ka ʻike ʻana i nā biomarkers no ka ʻike mua ʻana a me ka wānana.
• ʻO ka hoʻomaopopo ʻana i ke kumu genetic a me molecular maʻi ʻaʻai pancreatic.
• Ka hoʻomaikaʻi ʻana i nā ʻenehana hana.

Ka hopena

Hoʻomaopopo i ka hiki nā kumu maʻi maʻi pancreatic a me nā kumu pilikia e hoʻoikaika iā ʻoe e hoʻoholo i ka ʻike e pili ana i kou olakino. ʻOiai ʻo kekahi mau mea pilikia, e like me genetics, ʻaʻole i hiki iā ʻoe ke hoʻomalu, ʻo ka lawe ʻana i kahi nohona olakino a me ka hana pū ʻana me kāu kauka hiki ke hōʻemi nui i kou pilikia. Hoʻolaʻa ʻia nā ʻepekema a me nā kauka ma Shandong Baofa Cancer Research Institute no ka holomua ʻana i ka ʻike maʻi ʻaʻai pancreatic a me ka hoʻomohala ʻana i nā lāʻau lapaʻau ʻoi aku ka maikaʻi. E hoʻomau i ka ʻike, e hoʻokahua i kou olakino, a kamaʻilio pū me nā limahana mālama ola no ke alakaʻi pilikino.

Hōʻole: Hāʻawi kēia ʻatikala i ka ʻike maʻamau a ʻaʻole pono e manaʻo ʻia he ʻōlelo aʻoaʻo olakino. Kūkākūkā me kahi ʻoihana mālama ola kūpono no ke alakaʻi pilikino a me nā koho lapaʻau.

Nā kumu:

1. American Cancer Society: www.cancer.org
2. National Cancer Institute: www.cancer.gov
3. Pūnaehana hana maʻi maʻi pancreatic: www.pancan.org