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Qalisa kabusha
U-Baofa Yu, uDokotela Omkhulu we-M.D. e-China, u-Adjunct Professor e-University of Texas (El Paso) (2016) kanye noProfessor Oyi-Adjunct e-Western University of Health Sciences (2016). Uthole iziqu e-Peking Union Medical College (Peking Union Medical College) ngo-1988. Wayengumfundi wangemva kukadokotela e-UCSD kusukela ngo-1990 kuya ku-1991, u-Salk kusukela ngo-1992 kuya ku-1993, uProfessor Adjunct Assistant, UCSD kusukela ngo-1994 kuya ku-1998. Wasungula umqondo omusha wokusebenzisa izicubu zesimila njengohlelo oluqhubekayo lokukhululwa kwezidakamizwa ezilwa nomdlavuza kanye nendlela yokwelapha yokugcina amanzi okukhululwa, enenani lesicelo somtholampilo, futhi ibizwa ngokuthi i-ultro-Minimum incision personalized intratumoral chemoimmunotherapy (UMIPIC). Ngo-1998, wabuyela e-China futhi wasungula i-Shandong Baofa Research Institute kanye ne-Taimei Baofa Cancer Hospital endaweni yasemakhaya yase-Dongping ngokutshalwa kwezimali kwezobuchwepheshe, futhi wasebenza njengosihlalo we-Shandong Baofa Cancer Treatment Co., LTD., Futhi kamuva wasungula i-Jinan Baofa Cancer Hospital (2004). I-Dongping Baofa General Hospital (2011), Beijing Baofa Cancer Hospital (2013) kanye ne-Immuno Oncology Systems, Inc. Le UMIPIC iphephile, kulula ukuyisebenzisa, futhi ikhiqizeka futhi ngenzuzo enhle yazo zonke izimila eziqinile. Namuhla lokhu kwelashwa kwamukelwe "Izinkombandlela Zokusebenza Komtholampilo Zokwelashwa Okungenele Kwe-Advanced Pancreatic Cancer" (Trial) (uhlelo lwesi-7), olwakhiwe ngokuhlanganyela yi-Chinese Anti-Cancer Association, i-National Clinical Medical Research Center for Radiology and Therapy, kanye ne-National Interventional Medicine Innovation Alliance, Journal of Clinical Radiology, ivolumu 43, 63, inombolo ye-63-162.
Ushicilele amaphepha angaphezu kwama-60 mayelana nalokhu kwelashwa ku-Nature:Scientific Report, Journal of Cancer, J Basic Clin Pharma, J Immunological Sci, Japanese Journal of Gastroenterology and Hepatology, Novel Approaches in Cancer Study, Academic Journal of Engineering Studies, Nov Res Sci, Journal of Hepatocellular carcinoma, Lung Journal disorder, I-Target Journal of Lung Cancer, Ijenali yaseShayina of Chest,Proc.Natl.Acad.Sci.USA, Pancreas namanye amajenali kanye namaphepha amaningi okuposa abambe iqhaza kumhlangano we-AACR ne-ASCO.
Umnikelo wethu omkhulu ukuthi ukwelapha okukhishwa okuqhubekayo kuhlanganisa izinzuzo ze-chemotherapy kanye ne-immunotherapy, futhi ngokokuqala ngqa, lezi zibili zihlangene futhi zasetshenziswa ekwelapheni kwe-intratumoral ngokungenelela. Ihlanganisa ukwelashwa kwendawo kanye nembulunga yonke, futhi ikhulise ukugxila kanye nesikhathi sesenzo somuthi ngokudedelwa okuqhubekayo kwezidakamizwa ngaphakathi kwesimila, esingagcini nje ngokudlala umthelela wendawo we-anticancer wezidakamizwa ze-chemotherapy, kodwa futhi icabangela indima ye-systemic immunotherapy, ngaleyo ndlela yenza ukushiyeka kwezinye izindlela zokwelapha, inikeza imibono emisha nezindlela zokwelapha umdlavuza, ikakhulukazi izimila ezimaphakathi nezithuthukile, ikakhulukazi ekunciphiseni ukubaluleka kokuphindaphinda kwesimila esibalulekile kakhulu; Ukwelashwa kwe-UMPIC kunenzuzo yokusebenzisa isimila njengomthombo we-antigen kanye nomuthi wokugomela i-autologous, ophinde uhambisane nokuthuthuka komuthi Owenziwe Umuntu. Futhi isetshenziswa emtholampilo, i-hapten ehlanganiswe nemithi ye-chemotherapy yokwelashwa okuqhubekayo komdlavuza we-pancreatic, ngenkathi idala umphumela we-distal, ingqikithi yawo ukuletha impendulo yokuzivikela komzimba, amaseli ahlobene ne-T-cell-CD4, CD8, DC, T kanye ne-NK, kanye nama-autoantibodies ahlobene ne-B-cell-cell: Ama-Antibodies kuya ku-P53, P16, I-Cmyc, I-Survic, i-HCC, i-Cmytac, i-HCC kanye namanye ama-oncogenes, kungokokuqala ngqa ukuthola ukuthi i-T kanye ne-B ihileleke ekuphenduleni kwamasosha omzimba, kanye nemisebenzi yomtholampilo yomphumela we-distal kanye nalokhu kwelashwa kwakhethelwa "Iziqondiso Zokusebenza Komtholampilo Zokwelashwa Okungenele Ukwelashwa Kwe-Advanced Pancreatic Cancer" (Trial) (uhlelo lwesi-7) olwakhiwe ngokuhlanganyela yi-Chinese Anti-Cancer Association, iNational Clinical Medical Research kanye ne-National Clinical Research Centre eshicilelwe I-National Clinical Medical Research kanye ne-Alliance National Research Centre eshicilelwe. ku-Journal of Clinical Radiology, umthamo 43, inombolo 19, 2024, 1636-1648.
Izithenjwa:
| Unyaka | Isihloko Sesihloko | Ukushicilelwa |
| 2015 | Umphumela wokwelapha othuthukisiwe we-Hapten ezigabeni ezithuthukile zomdlavuza wamaphaphu ngokusika kwe-ultra-minimum personalized intratumoral | Umdlavuza wamaphaphu: Ithagethi kanye Nokwelashwa, 2015; 6 1-11 |
| 2015 | Ukuvikela okuvamile ukuze kubulawe kangcono umdlavuza | 2015 Ababhali. ICancer Medicine eshicilelwe nguJohn Wiley & Sons Ltd.1349-1403 |
| 2015 | Ubuthakathaka Nezingibe Zokusebenzisa Amagundane namagundane ku-Cancer Chemoprevention Studies | Ijenali yomdlavuza 2015;6(10): 1058-1065.doi: 10.7150/jca.12519 |
| 2015 | Isikhathi sokusinda esithuthukisiwe se-Hapten ku-advanced hepatocellular carcinoma nge-ultra-minimum incision personalized intratumoral chemoimmunotherapy | Ijenali ye-Hepatocellular Carcinoma, 2015:2,1-12 |
| 2015 | Ukusetshenziswa kwezidakamizwa ze-Catatonic ezihlanganisiwe ze-hapten zokuthuthukisa umphumela wokwelapha ezigabeni ezithuthukisiwe ze-Pancreatic Cancer | Ijenali Yocwaningo Lwesibindi, Izifo Nokwelashwa, 2015,1(3):013-23 |
| 2016 | Ukufunda Ngokubaluleka Kokuvimbela Inguquko Emidlalweni Elaphekayo kanye Nama-Benign Tumors | Ijenali Yomdlavuza 2016; 7(4): 436-445. doi: 10.7150/jca.13832 |
| 2016 | I-Hapten Ithuthukisiwe Inzuzo Yokusinda Iphelele Ezigabeni Zakamuva Zomdlavuza Ongewona Omncane Weseli Wamaphaphu (NSCLC) nge-Ultra-Minimum Incision Personalised Intratumoral Chemo Immunotherapy (UMIPIC) Ukwelashwa Ngokusebenzisa nangaphandle Kokwelashwa Kweradiation Thumela Umbhalo Wesandla | Ijenali Yokuvimbela Umdlavuza Nocwaningo Lwamanje 2016, 4(2): 00116 |
| 2020 | I-Novel Eclectic Approach ye-Cancer Therapy ene-Liquid Knife & Immuno Therapy: UMIPIC, ingase Idlule Ukuhlinzwa Okuningi, I-Chemotherapy kanye Ne-Radiation Therapy yazo zonke Izigaba Ze-Solid Tumor. | Izindlela Ezinoveli Ocwaningweni LweCancer NACS.000590. 4(3).2020 |
| 2020 | Umuthi Oxutshwe I-H2O2 Injection Intratumoral ukuze uguqule i-Extracellular Matrix ibe yi-Autologous Coagulum njengeDepho Yezidakamizwa | Ucwaningo Lwenoveli Lwezesayensi NRS.000584. 4(2).2020 |
| 2020 | Ithemba Elisha Lokwelapha Ngomdlavuza Nge-Liquid Knife & Immuno Therapy: UMIPIC | Okuthrendayo Kwamanje Kwesayensi Yezokwelapha Nezokwelapha ISSN:2689-4246 Idethi Yokushicilela: Mashi 20, 2020 |
| 2022 | I-Acute Tumor Inflammation ene-CD4/8+ kanye ne-CD11+ Ethuthukisiwe Isikhathi Sokusinda Okude Ezigabeni Ezithuthukisiwe zazo zonke izimila eziqinile nge-Ultra Minimum Incision Personalized Intratumoral Chemoimmunotehrapy | Ijenali yaseJapan yeGastroenterology kanye neHepatology |
| 2022 | Ukuvuvukala Okunamandla Okuvezwa Okukhethekile kwe-CD11 & CD4 Kukhiqiza Umphumela We-Abscopal Nge-Intramoral Injection Chemotherapy Drug with Hapten in Animal Model. | Ijenali ye-Immunological Sciences |
| 2022 | Inkathi Entsha Yokuhlinzwa Kwe-Immuno Iyeza: Indlela Enoveli Ye-Eclectic Yokwelapha Umdlavuza Ngomese Owuketshezi kanye Nokwelashwa Kwe-Immuno | Ijenali Yezemfundo Yezifundo Zobunjiniyela |
| 2022 | I-Acute Tumor Inflammation ene-CD4/8+ kanye ne-CD11+ Yandisa Umphumela Wokusinda Obangelwa I-Intratumral Injection Optimum Combination of Chemotherapy Drugs with Hydralazine as Hapten in Animal Model | Ijenali yaseJapan yeGastroenterology kanye neHepatology |
| 2023 | Vusa Amaseli Amasosha omzimba nge-Hapten Enhanced Intratumoral Chemotherapy nge-Penicillin Prolong Pancreatic Cancer Survival | Ijenali Yomdlavuza 2023; 14(8): 1282-1292 |
| 2023 | Ukuqondisa ngempumelelo endaweni ye-oncogenic nuclear antigen nge-hapten induced tumor associated autoantibodies (iTAA) | iphothifoliyo yemvelo Imibiko Yesayensi ivolumu 13, Inombolo ye-athikili: 9902 (2023) |
| 2023 | Izinguquko Zamasosha omzimba Ezibangelwa I-Intratumoral Hapten Plus Chemotherapy Izidakamizwa ze-EndometrialCancer | Ijenali ye-Basic and Clinical Pharmacy Julayi 31,2023. I-DOI: 10.37532/0976-0113.14(S1).17 |
| 2023 | Ukulungiselela Ukwelashwa Kwe-Cancer Immunotherapy kanye Nokuqaliswa Kwamaseli Amasosha omzimba Nge-Hapten-Enhanced Chemotherapy ku-Primary Lung Cancer | Ijenali ye-Basic and Clinical Pharmacy Agasti 11, 2023. DOI: 10.37532/0976-0113.14(S1).18 |
| 2023 | Ukuhlaziywa kwe-scRNA-Seq Izinguquko Zokuzivikela Ezifweni Zezidakamizwa Ze-Intratumoral Hapten Plus Chemotherapy Zokwelapha Umdlavuza Webele Wabesilisa | IJOURNAL OF CANCER SCIENCE AND CLINICAL THERAPEUTICS Novemba 27, 2023. DOI:10.26502/jcsct.5079214 |
| 2024 | Umphumela we-sodium stibogluconate ekuqasheni nasekuvuseni amaseli omzimba ku-pleural fluid yokulungiselela umdlavuza we-pancreatic we-immunotherapy. | I-Frontiers ku-Immunology Januwari 19, 2024. DOI:10.3389/fimmu.2023.1315468 |
| 2024 | I-Hapten-Mediated Chemical Immune Therapy With Drug Administration ibe Umdlavuza Womlomo wesibeletho ngaphandle kwe-Hysterectomy | Ijenali Yokuhlinzwa Juni 13, 2024. DOI:10.29011/2575-9760.11063 |
| 2024 | Sebenzisa Iphrofayili ye-scRNA-Seq Ukuchaza Impendulo Ye-Immunologic Ngemva Kwe-Intra-tumor Hapen I-Chemotherapy Ethuthukisiwe Ecaleni Le-Intracranial Anaplastic Hemangiopericytoma Liver Metastasis: Umbiko Wecala | Ijenali Yokuhlinzwa Juni 10, 2024. DOI:10.29011/2575-9760.11063 |
