Qhubeka

Qhubeka

Qhubeka

20241205093268316831

U-Baofa Yu, uM.D. UGqirha oyiNtloko e-China, uNjingalwazi oyiNtloko kwiYunivesithi yaseTexas (El Paso) (i-2016) kunye noNjingalwazi oNxibelelayo kwiYunivesithi yaseNtshona yeSayensi yezeMpilo (2016). Waphumelela kwi-Peking Union Medical College (Peking Union Medical College) ngo-1988. Wayengugqirha emva kwe-UCSD ukusuka kwi-1990 ukuya kwi-1991, u-Salk ukusuka kwi-1992 ukuya ku-1993, uMncedisi oMncedisi onguNjingalwazi, u-UCSD ukusuka kwi-1994 ukuya kwi-1998. E-United States wayesebenzisa iziyobisi kwi-dumor carrier kunye nophando lomhlaza we-biology. Wayila ingcamango entsha yokusebenzisa i-tumor tissue njengenkqubo yokukhululwa ezinzileyo yamachiza e-anticancer kunye nendlela yonyango yokugcina ukukhululwa kwe-reservoir, enexabiso lesicelo sekliniki, ikwabizwa ngokuba yi-ultro-Minimum incision personalized intratumoral chemoimmunotherapy (UMIPIC). Ngo-1998, wabuyela e-China waza waseka i-Shandong Baofa Research Institute kunye ne-Taimei Baofa Cancer Hospital kwindawo yase-Dongping yasemaphandleni kunye nokutyalomali kwezobuchwepheshe, kwaye wakhonza njengosihlalo we-Shandong Baofa Cancer Treatment Co., LTD., Kwaye kamva waseka i-Jinan Baofa Cancer Hospital (2004). Dongping Baofa General Hospital (2011), Beijing Baofa Cancer Hospital (2013) kunye Immuno Oncology Systems, Inc. Le UMIPIC ikhuselekile, kulula ukusebenza, kwaye reproducible ngenzuzo elungileyo yonke ithumba eqinileyo. Namhlanje olu nyango lwamkelwe "Izikhokelo zokuSebenza kweClinical for Interventional Treatment of Advanced Pancreatic Cancer" (Trial) (i-7th edition), iqulunqwe ngokudibeneyo yi-Chinese Anti-Cancer Association, i-National Clinical Medical Research Centre for Radiology and Therapy, kunye ne-National Interventional Medicine Innovation Alliance, Journal of Clinical Radiology, umthamo we-43, 61620.

Upapashe ngaphezu kwamaphepha angama-60 malunga nolu nyango kwiNdalo: Ingxelo yeNzululwazi, i-Journal of Cancer, i-J Basic Clin Pharma, i-J Immunological Sci, i-Japan Journal ye-Gastroenterology kunye ne-Hepatology, i-Novel Approaches kwi-Cancer Study, i-Academic Journal of Engineering Studies, i-Nov Res Sci, i-Journal ye-Hepatocellular carcinoma, i-Lung Journal ye-Cancer, i-Lung Journal ye-Lung Cancer of Chest, Proc.Natl.Acad.Sci.USA, Pancreas kunye nezinye iijenali kunye namaphepha amaninzi eposi athathe inxaxheba kwintlanganiso ye-AACR ne-ASCO.

Igalelo lethu elikhulu kukuba unyango olusisigxina ludibanisa izibonelelo ze-chemotherapy kunye ne-immunotherapy, kwaye ngokokuqala ngqa, ezi zimbini zidibene kwaye zisetyenziselwa unyango lwe-intratumoral ngokungenelela. Idibanisa unyango lwasekhaya kunye nehlabathi jikelele, kwaye inyusa ugxininiso kunye nexesha lesenzo sechiza ngokukhutshwa okuqhubekayo kwamachiza ngaphakathi kwethumba, elingadlali kuphela impembelelo ye-anticancer yendawo yamachiza e-chemotherapy, kodwa ithathela ingqalelo indima ye-systemic immunotherapy, ngaloo ndlela yenza ukusilela kolunye unyango, ibonelela ngeembono ezintsha kunye neendlela zonyango lomhlaza, ngakumbi kumathumba aphakathi kunye naphambili, ngakumbi ekunciphiseni ukuphindaphinda kwe-tumor ebaluleke kakhulu; Unyango lwe-UMPIC lunenzuzo yokusebenzisa ithumba njengomthombo we-antigen kunye nogonyo lwe-autologous, olukwahambelana nendlela yophuhliso lwe-Personalized Medicine. Kwaye ifakwe kwiklinikhi, i-hapten idityaniswe namachiza e-chemotherapy ukwenzela unyango oluqhubekayo lokukhululwa komhlaza we-pancreatic ugxininiso oluphambili, ngelixa lubangela umphumo we-distal, undoqo wayo kukubangela impendulo yomzimba, i-CD4 ehlobene ne-T-cell, i-CD8, i-DC, i-T kunye ne-NK iiseli, kunye ne-B-cell-related tumor autoantibodies: Antibodies ukuya kwi-P53, i-P16, i-Cmytac, i-Survic, i-HCC, i-HCC kunye nezinye i-oncogenes, eli lixesha lokuqala lokufumanisa ukuba i-T kunye ne-B zibandakanyeka kwi-immune response, kunye nemisebenzi yeklinikhi yempembelelo ye-distal kwaye olu nyango lukhethwe "Izikhokelo zeClinical Operation Guidelines for Interventional Treatment of Advanced Pancreatic Cancer" (Trial) (i-7th edition) iqulunqwe ngokudibeneyo yi-Chinese Anti-Cancer Association, i-National Clinical Medical Research Centre kunye ne-National Clinical Research Centre epapashwe kwi-National Clinical Research kunye neZiko loPhando lweSizwe. kwi Journal of Clinical Radiology, volume 43, number 19, 2024, 1636-1648.

IiReferensi:

Unyaka Isihloko senqaku Ushicilelo
2015 Impembelelo yonyango eyongeziweyo ye-Hapten kumanqanaba aphambili omhlaza wemiphunga nge-ultra-minimum minimum incision personalized intratumoral Umhlaza Wemiphunga: Ithagethi kunye noNyango, 2015;6 1-11
2015 Ukukhusela okuqhelekileyo ukuze kubulawe ngcono umhlaza 2015 Ababhali. Cancer Medicine epapashwe nguJohn Wiley & Sons Ltd.1349-1403
2015 Ubuthathaka kunye nemigibe yokusebenzisa iigundane kunye neempuku kwi-Cancer Chemoprevention Studies Ijenali yeCancer 2015;6(10): 1058-1065.doi: 10.7150/jca.12519
2015 I-Hapten-eyongeziweyo iyonke ixesha lokusinda kwi-hepatocellular carcinoma nge-ultra-minimum incision personalized intratumoral chemoimmunotherapy Ijenali ye-Hepatocellular Carcinoma, 2015: 2, 1-12
2015 Ukusetyenziswa kweziyobisi ze-hapten ezidityanisiweyo zeCatatonic zokuphucula isiphumo soNyango kwiNqanaba eliPhezulu lePancreatic Cancer Ijenali yoPhando lwesibindi, iZiyalo kunye noNyango, 2015,1(3):013-23
2016 Ukufunda ngokubaluleka koThintelo lweNguqu kwiCancer eNyangekayo kunye neBenign Tumors Ijenali yoMhlaza ka-2016; 7(4): 436-445. doi: 10.7150/jca.13832
2016 IHapten iPhucule iNzuzo yokuSinda ngokuGqibeleyo kuManqanaba amva woMhlaza ongeNcinci weSeli yemiphunga (NSCLC) yi-Ultra-Minimum Minimum Incision Personalized Intratumoral Chemo Immunotherapy (UMIPIC) Unyango kunye nangaphandle koNyango lweRadiation Ngenisa umbhalo-ngqangi. Ijenali yoThintelo lweCancer kunye noPhando lwangoku 2016, 4(2): 00116
2020 Indlela yeNoveli ye-Eclectic yoNyango lweCancer eneLiquid Knife kunye ne-Immuno Therapy: UMIPIC, inokogqitha uTyando oluninzi, iKhemotherapy kunye noNyango lweRadiation kuwo onke amabakala eSolid Tumor. IiNdlela zeNoveli kuFundo loMhlaza NACS.000590. 4(3).2020
2020 Ichiza elixutywe yi-H2O2 Isitofu se-Intratumoral ekuguquleni i-Matrix ye-Extracellular ibe yi-Autologous Coagulum njengeDepo yeziyobisi. UPhando lweNoveli kwiiNzululwazi NRS.000584. 4(2).2020
2020 Ithemba elitsha loNyango lweCancer ngeLiquid Knife & Immuno Therapy: UMIPIC IiNdlela eziNtsha ngoku kwiNzululwazi yezoNyango ISSN:2689-4246 Umhla wokuPapashwa: 20 Matshi 2020
2022 I-Acute Tumor Inflammation ene-CD4/8+ kunye ne-CD11+ eyomeleziweyo ixesha elide lokuSinda kwiNqanaba eliPhezulu lazo zonke iithumba eziqinileyo nge-Ultra Minimum Incision Personalized Intratumoral Chemoimmunotehrapy Ijenali yaseJapan yeGastroenterology kunye neHepatology
2022 Ukudumba okuKhawuleza okuneNgcaciso ekhethekileyo ye-CD11 kunye ne-CD4 Ivelisa i-Abscopal Effect yi-Intramoral Injection Chemotherapy Chiza ene-Hapten kwiModeli yeZilwanyana. Ijenali yeSayensi ye-Immunological
2022 Ixesha elitsha loTyando lwe-Immuno luyeza: Indlela entsha ye-Eclectic yoNyango loMhlaza ngeLiquid Knife & Immuno Therapy Ijenali yezifundo zobuNjineli
2022 I-Acute Tumor Inflammation kunye ne-CD4 / 8 + kunye ne-CD11 + Yokwandisa Isiphumo Sokusinda esibangelwa yi-Intratumral Injection Optimum Combination ye-Chemotherapy Drugs kunye ne-Hydralazine njenge-Hapten kwi-Animal Model. Ijenali yaseJapan yeGastroenterology kunye neHepatology
2023 Vusa iiSeli ze-Immune nguHapten ophuculweyo we-Intratumoral Chemotherapy kunye nePenicillin Yokwandisa ukusinda koMhlaza wePancreatic Ijenali yoMhlaza ka-2023; 14(8): 1282-1292
2023 Ujoliso oluphumeleleyo kwindawo ye-oncogenic ye-antigen yenyukliya nge-hapten induced tumor eyayanyaniswa ne-autoantibodies (iTAA) ipotifoliyo yendalo IiNgxelo zeSayensi umthamo we-13, inombolo yenqaku: 9902 (2023)
2023 Utshintsho kuMzimba olwenziwa yi-Intratumoral Hapten Plus Chemotherapy Drugs of EndometrialCancer Ijenali yeSiseko kunye neClinical Pharmacy Julayi 31,2023. I-DOI: 10.37532/0976-0113.14(S1).17
2023 Ukulungiswa kwe-Cancer Immunotherapy kunye nokuSebenzisa iiSeli ze-Immune nge-Hapten-Enhanced Chemotherapy kwi-Primary Lung Cancer Ijenali yeSiseko kunye neClinical Pharmacy Agasti 11, 2023. DOI: 10.37532/0976-0113.14 (S1) .18
2023 Uhlalutyo lwe-scRNA-Seq Uguquko lwe-Intratumoral Hapten Plus Chemotherapy yoNyango loMhlaza wamabele weMadoda IJOURNAL OF CANCER SCIENCE AND CLINICAL THERAPEUTICS Novemba 27, 2023. DOI:10.26502/jcsct.5079214
2024 Impembelelo ye-sodium stibogluconate ekufuneni nasekuvuseni iiseli zomzimba kwi-pleural fluid yokulungiselela umhlaza wepancreatic kwi-immunotherapy. Imida kwi-Immunology ngoJanuwari 19, 2024. DOI:10.3389/fimmu.2023.1315468
2024 I-Hapten-Mediated Chemical Immune Therapy kunye noLawulo lweChiza kwiCancer yoMkhosi ngaphandle kweHysterectomy Ijenali yoTyando ngoJuni 13, 2024. DOI:10.29011/2575-9760.11063
2024 Sebenzisa iProfayili ye-scRNA-Seq Ukuchaza i-Immunologic Response emva kwe-Intra-tumor Hapen Eyongeziweyo Chemotherapy kwi-Case of Intracranial Anaplastic Hemangiopericytoma Liver Metastasis: Ingxelo yeNgxelo Ijenali yoTyando ngoJuni 10, 2024. DOI:10.29011/2575-9760.11063
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