ʻO ka mālama ʻana i ka maʻi maʻi pancreatic: He alakaʻi piha 

ʻO ka mālama ʻana i ka maʻi maʻi pancreatic pili nā koho i ke kahua a me kahi o ka maʻi kanesa, a me ke olakino holoʻokoʻa o ka mea maʻi. ʻO nā lāʻau lapaʻau maʻamau, ʻo ia ka ʻoki ʻana, ka chemotherapy, radiation therapy, a me ka lāʻau lapaʻau. Hoʻohana pinepine ʻia ka hui ʻana o kēia mau ala e hoʻokō i ka hopena maikaʻi loa. He mea koʻikoʻi ka hoʻomaopopo ʻana i kēia mau koho no ka hoʻoholo ʻana.

Ka hoʻomaopopo ʻana i ka maʻi maʻi pancreatic

ʻO ka pancreas kahi okana ma hope o ka ʻōpū e hana koʻikoʻi i ka hoʻoponopono ʻana a me ke kō koko. ʻO ka maʻi ʻaʻai pancreatic hiki i ka wā e ulu ʻole ai nā pūnaewele i loko o ka pancreas me ka ʻole o ka hoʻopaʻa ʻia ʻana, e hana ana i kahi ʻōpū. Elua ano nui o maʻi ʻaʻai pancreatic: adenocarcinoma (ke ʻano maʻamau) a me nā ʻōpū neuroendocrine (PNETs).

ʻO nā kumu pilikia no ka maʻi maʻi pancreatic

Hiki i kekahi mau kumu ke hoʻonui i ka pilikia o ka ulu ʻana maʻi ʻaʻai pancreatic, me:

• Puhi paka
• Diabetes
• ʻObesity
• ʻO ka maʻi maʻi pancreatitis
• Moolelo ohana o maʻi ʻaʻai pancreatic
• ʻO kekahi mau genetic syndromes

Nā hōʻailona o ka maʻi maʻi pancreatic

I ka wā mua, maʻi ʻaʻai pancreatic ʻaʻohe mau hōʻailona ʻike pinepine ʻia. I ka ulu ʻana o ka maʻi kanesa, hiki ke komo i nā hōʻailona:

• ʻEha ʻōpū
• ʻO Jaundice (ka melemele o ka ʻili a me nā maka)
• Paona kaumaha
• Pau ka ʻai
• Nausea a me ka luai
• Nā hoʻololi ʻana i ka ʻōpū
• ʻO ka maʻi diabetes hou

ʻIke ʻia o ka maʻi maʻi ʻaʻai pancreatic

Ina maʻi ʻaʻai pancreatic manaʻo ʻia, e hana ke kauka i kahi hoʻokolohua kino a kauoha i nā hoʻokolohua like ʻole, e like me:

• Nā hoʻāʻo koko: No ka nānā ʻana i ka hana o ka ate a me nā hōʻailona tumor.
• Nā ho'āʻo kiʻi: E like me ka CT scans, MRI scans, a me ka endoscopic ultrasound (EUS), e nānā i ka pancreas a me nā hale a puni.
• Biopsy: E hōʻoia i ka hōʻailona a hoʻoholo i ke ʻano o maʻi ʻaʻai pancreatic.

Nā koho lapaʻau maʻi maʻi pancreatic

Ka lapaau no maʻi ʻaʻai pancreatic pili i kekahi mau kumu, e like me ka pae o ka maʻi kanesa, kona wahi, a me ke olakino holoʻokoʻa o ka mea maʻi. Hōʻike ʻia nā koho lapaʻau nui ma lalo nei. Hāʻawi ka Shandong Baofa Cancer Research Institute kaulana i ka mālama maʻi maʻi; hiki iā ʻoe e aʻo hou ma aneʻi e pili ana i kā lākou hoʻokokoke ʻana.

ʻO ka ʻoki ʻana

ʻO ka ʻokiʻoki pinepine ka lāʻau lapaʻau mua no maʻi ʻaʻai pancreatic inā ʻaʻole i hoʻolaha ʻia ka maʻi maʻi i nā kino ʻē aʻe. Hiki ke hoʻohana ʻia nā kaʻina hana ʻokoʻa ma muli o ka wahi o ka ʻōpū:

• ʻO ke kaʻina hana whipple (pancreaticoduodenectomy): E pili ana kēia i ka wehe ʻana i ke poʻo o ka pancreas, kahi hapa o ka ʻōpū liʻiliʻi, ka gallbladder, a me kahi ʻāpana o ka ʻawa bile.
• Pancreatectomy Distal: Hoʻopili kēia i ka wehe ʻana i ka huelo o ka pancreas a hiki ke komo pū me ka spleen.
• ʻO ka pancreatectomy holoʻokoʻa: E pili ana kēia i ka wehe ʻana i ka pancreas holoʻokoʻa, spleen, gallbladder, ʻāpana o ka ʻōpū, a me kahi hapa o ka ʻōpū liʻiliʻi. He emi kēia.

ʻO ka hiki ke hoʻoneʻe maikaʻi ʻia ka ʻōpū ma muli o kona wahi a me kona pae. He mea koʻikoʻi kēia i ka hoʻoholo ʻana i nā koho lapaʻau. Hiki i ka ʻike loea ke hoʻoikaika nui i nā hopena, e hana ana i nā ʻoihana e like me Shandong Baofa Cancer Research Institute i nā kumu waiwai nui no nā maʻi.

Kemoterapi

Hoʻohana ʻo Chemotherapy i nā lāʻau lapaʻau e pepehi i nā maʻi kanesa. Hiki ke hoʻohana ʻia ma mua o ka ʻoki ʻana (neoadjuvant chemotherapy), ma hope o ke kaʻina (adjuvant chemotherapy), a i ʻole ma ke ʻano he lāʻau lapaʻau mua no ka holomua. maʻi ʻaʻai pancreatic. ʻO nā lāʻau lapaʻau maʻamau i hoʻohana ʻia e mālama maʻi ʻaʻai pancreatic komo:

• ʻO Gemcitabine
• FOLFIRINOX (kahi hui o fluorouracil, leucovorin, irinotecan, a me oxaliplatin)
• ʻO Abraxane (nā ʻāpana paclitaxel paʻa i ka protein)

Hiki i ka Chemotherapy ke hana i nā hopena ʻaoʻao, e like me ka nausea, ka luaʻi, ka luhi, a me ka lilo o ka lauoho. Hiki ke mālama pinepine ʻia kēia mau hopena ʻaoʻao me ka lāʻau lapaʻau a me ka mālama kākoʻo.

Lapaʻau Radiation

Hoʻohana ka lāʻau lapaʻau i nā kukuna ikaika nui e pepehi i nā maʻi maʻi maʻi. Hiki ke hoʻohana ʻia ma mua o ka ʻoki ʻana, ma hope o ke ʻoki ʻana, a i ʻole ma ke ʻano he lapaʻau mua no maʻi ʻaʻai pancreatic. ʻO nā ʻano o ka radiation therapy nā:

• ʻO ka lāʻau lapaʻau lāʻau o waho (EBRT): Hāʻawi ʻia ka hoʻoheheʻe ʻana mai kahi mīkini ma waho o ke kino.
• Brachytherapy: Hoʻokomo pololei ʻia nā hua radioactive i loko a kokoke paha i ka ʻōpū.

Hiki i ka lāʻau lapaʻau ke hana i nā hopena ʻaoʻao, e like me ka ʻili o ka ʻili, ka luhi, a me ka nausea.

ʻO ka Lapaʻau Kūlohelohe

Hoʻohana ʻia ka lāʻau lapaʻau i hoʻopaʻa ʻia i nā molekole kikoʻī e pili ana i ka ulu ʻana o ka cell cancer a me ke ola. Nā laʻana o nā lāʻau lapaʻau i hoʻohana ʻia e mālama maʻi ʻaʻai pancreatic komo:

• Erlotinib: Kuhi i ka epidermal growth factor receptor (EGFR).
• Olaparib: Ke kuhi nei i ka enzyme PARP i nā maʻi me nā hoʻololi BRCA.

Immunotherapy

Kōkua ka Immunotherapy i kāu ʻōnaehana pale ʻana i ka maʻi kanesa. ʻAʻole i hoʻohana pinepine ʻia ma ke ʻano he lāʻau lapaʻau mua no maʻi ʻaʻai pancreatic akā he koho paha i kekahi mau hihia. ʻO Pembrolizumab (Keytruda) kahi lāʻau immunotherapy hiki ke hoʻohana ʻia no maʻi ʻaʻai pancreatic nā maʻi me nā hoʻololi genetic kikoʻī.

Malama Palliative

Hoʻopili ka mālama palliative i ka hoʻomaha ʻana i nā hōʻailona a me ka hoʻomaikaʻi ʻana i ka maikaʻi o ke ola no nā maʻi me nā maʻi koʻikoʻi, e like me maʻi ʻaʻai pancreatic. Hiki i ka mālama palliative ke komo i ka hoʻoponopono ʻeha, ke kākoʻo meaʻai, a me ke kākoʻo naʻau.

Nā ʻanuʻu o ka maʻi maʻi pancreatic a me nā ala lapaʻau

ʻO ka maʻi ʻaʻai pancreatic hoʻonohonoho ʻia e hoʻoholo i ka nui o ka maʻi kanesa a alakaʻi i nā hoʻoholo lapaʻau. Aia nā pae mai ka pae 0 (cancer in situ) a i ka pae IV (metastatic cancer). Hōʻuluʻulu ka papa ma lalo nei i nā ala lapaʻau no kēlā me kēia pae:

Noho me ka ma'i ma'i pancreatic

Noho me maʻi ʻaʻai pancreatic hiki ke paʻakikī, akā aia nā kumuwaiwai e kōkua i nā maʻi a me ko lākou ʻohana e hoʻokō. Hiki i nā hui kākoʻo, nā ʻōlelo aʻo, a me nā papahana hoʻonaʻauao ke hāʻawi i ke kōkua koʻikoʻi. ʻO ka mālama ʻana i ke ola olakino, me ka ʻai kaulike a me ka hoʻoikaika mau, hiki ke hoʻomaikaʻi i ka maikaʻi o ke ola.

ʻO ke kuleana o nā hoʻokolohua lapaʻau

ʻO nā hoʻokolohua hoʻokolohua he noiʻi noiʻi e loiloi i nā mea hou lapaʻau maʻi ʻaʻai pancreatic hoʻokokoke. ʻO ke komo ʻana i kahi hoʻokolohua lapaʻau hiki ke hāʻawi i ke komo ʻana i nā lāʻau lapaʻau ʻokiʻoki a kōkua i ka holomua o ka mālama maʻi kanesa. Pono nā poʻe maʻi makemake i nā hoʻokolohua lapaʻau e kūkākūkā i ka hiki me kā lākou hui mālama olakino.

Ka hopena

ʻO ka mālama ʻana i ka maʻi maʻi pancreatic paʻakikī a koi ʻia kahi ala multidisciplinary. ʻO ka hoʻomaopopo ʻana i nā koho lapaʻau i loaʻa, nā pae, a me nā kumuwaiwai mālama kākoʻo hiki ke hoʻoikaika i nā poʻe maʻi e hoʻoholo i ka ʻike a hoʻomaikaʻi i kā lākou hopena. E kūkākūkā mau me kāu mea mālama ola e hoʻoholo i ke ala maikaʻi loa no kāu kūlana kikoʻī. Me ka hui i hoʻolaʻa ʻia ma Shandong Baofa Cancer Research Institute, pono e mālama ʻia nā mea maʻi me ke aloha a me ke akamai.

Disclaimer: Hāʻawi kēia ʻatikala i ka ʻike maʻamau e pili ana lapaʻau maʻi ʻaʻai pancreatic a ʻaʻole pono e manaʻo ʻia he ʻōlelo aʻo lapaʻau. E kamaʻilio mau me kahi ʻoihana mālama ola kūpono no ka hōʻoia ʻana a me nā ʻōlelo aʻoaʻo lapaʻau.

Kuhikuhi:

1. National Cancer Institute. Lapaʻau Maʻi ʻaʻai Pancreatic (PDQ?)–Patient Version
2. ʻAmelika Hui Pū ʻIa. E pili ana i ka maʻi maʻi pancreatic