ʻO ka maʻi maʻi pancreas: ʻike, ʻike, a me nā koho lapaʻau 

ʻO ka maʻi maʻi pancreas He maʻi ia e hoʻokumu ʻia ai nā ʻiʻo ʻino i loko o nā ʻiʻo o ka pancreas, kahi okana ma hope o ka ʻōpū. He mea koʻikoʻi ka ʻike mua ʻana no ka mālama pono ʻana. Hāʻawi kēia ʻatikala i kahi ʻike piha o ka maʻi ʻaʻai pancreas, e uhi ana i kona mau kumu, hōʻailona, hōʻailona, ​​a me nā ʻano lapaʻau like ʻole, me nā koho ʻokiʻoki, chemotherapy, radiation therapy, a me nā mea lapaʻau i hoʻopaʻa ʻia.

ka hoomaopopo ana Ka maʻi maʻi ʻaʻai pancreas

ʻO ka pancreas kahi ʻeleʻele e pāʻani nui i ka ʻai ʻana a me ka hoʻoponopono ʻana i ke kō koko. Hoʻopuka ia i nā enzymes e kōkua i ka wāwahi ʻana i ka meaʻai a me nā hormones e like me ka insulin e hoʻomalu i ka pae glucose. ʻO ka maʻi maʻi pancreas hiki i ka wā e ulu ʻole ai nā pūnaewele i loko o ka pancreas me ka ʻole o ka hoʻopaʻa ʻia ʻana, e hana ana i kahi ʻōpū. Hiki i kēia mau maʻi koko ke hoʻopilikia i ka hana maʻamau o ka pancreas a hoʻolaha i nā wahi ʻē aʻe o ke kino.

Nā ʻano o Ka maʻi maʻi ʻaʻai pancreas

ʻO ke ʻano maʻamau o ka maʻi ʻaʻai pancreas ʻO ia ka adenocarcinoma, ka mea e puka mai ana mai nā pūnaewele exocrine e hana i nā enzyme digestive. ʻO nā ʻano like ʻole e pili ana i nā ʻōpū neuroendocrine (NETs), e ulu ana mai nā pūnaewele hana hormone. ʻOi aku ka maikaʻi o ka prognosis ma mua o ka adenocarcinomas. Ke nānā aku nei ʻo Shandong Baofa Cancer Research Institute i ka noiʻi ʻana i nā lāʻau lapaʻau no nā ʻano maʻi maʻi like ʻole, me nā ʻano like ʻole e like me nā ʻōpū neuroendocrine.

Nā mea pilikia no Ka maʻi maʻi ʻaʻai pancreas

Hiki i kekahi mau kumu ke hoʻonui i ka pilikia o ka ulu ʻana ka maʻi ʻaʻai pancreas, me:

• Puhi: ʻO ka puhi paka he kumu pilikia nui, e hoʻonui ana i ka pilikia ma ʻelua a ʻekolu manawa.
• ʻObesity: ʻO ka lilo ʻana i ke kaumaha a i ʻole ka momona e pili ana i kahi pilikia kiʻekiʻe.
• ʻO ka maʻi maʻi maʻi: ʻO ka poʻe me ka maʻi maʻi maʻi, ʻoi aku ka nui o ke ʻano 2, ʻoi aku ka nui o ka pilikia.
• ʻO ka maʻi maʻi maʻi: Hiki i ka ʻeha lōʻihi o ka pancreas ke hoʻonui i ka pilikia.
• Moʻolelo ʻohana: He moʻolelo ʻohana no ka maʻi ʻaʻai pancreas a i ʻole kekahi mau genetic syndromes hiki ke hoʻonui i ka pilikia.
• Makahiki: Piʻi ka pilikia me ka makahiki, me ka nui o nā maʻi i ʻike ʻia ma hope o 60 makahiki.
• Kekahi mau Genetic Syndromes: Nā kūlana e like me ka pancreatitis hereditary, Lynch syndrome, a me BRCA hoʻololi.

ʻO ka ʻike ʻana i nā hōʻailona o Ka maʻi maʻi ʻaʻai pancreas

I kona wā mua, ka maʻi ʻaʻai pancreas ʻaʻole pinepine nā hōʻailona ʻike. I ka ulu ʻana o ka ʻōpū, hiki ke alakaʻi i:

• ʻO Jaundice: ʻO ka melemele o ka ʻili a me nā maka, pinepine ʻia e ka maʻi maʻi e ālai ana i ka ʻawa bile.
• ʻEha o ka ʻōpū: ʻEha ma ka ʻōpū o luna e ʻā ana i ke kua.
• Paona Paona: Unexplained weight loss.
• Nalo o ka 'ai: Manaʻo piha wikiwiki a makemake ʻole paha e ʻai.
• Nausea a me ka luaʻi ʻana: Ma muli o kahi ʻōpū e kaomi ana ma ka ʻōpū.
• Nā hoʻololi ʻana i ka maʻa ʻana o ka ʻōpū: ka maʻi maʻi a i ʻole ka constipation.
• ʻO ka maʻi maʻi diabetes: ʻO ka maʻi maʻi diabetes hou a i ʻole ka paʻakikī i ka mālama ʻana i ka maʻi maʻi diabetes.

Ka hoʻopaʻa ʻana Ka maʻi maʻi ʻaʻai pancreas

Ina ka maʻi ʻaʻai pancreas Ua manaʻo ʻia, hiki ke hana ʻia kekahi mau hoʻāʻo e hōʻoia i ka hōʻoia a hoʻoholo i ka pae o ka maʻi kanesa. Hiki i kēia mau ho'āʻo ke komo:

• Nānā Kino a me ka mōʻaukala: E nīnau ke kauka e pili ana i kāu mau hōʻailona, ka mōʻaukala olakino, a me nā mea pilikia.
• Nā hoʻāʻo kiʻi:
  • CT Scan: Hāʻawi i nā kiʻi kikoʻī o ka pancreas a me nā ʻāpana a puni.
  • MRI: Hoʻohana i nā māla magnetic e hana i nā kiʻi o ka pancreas.
  • Endoscopic Ultrasound (EUS): Hoʻohana i ka endoscope me ka ʻimi ultrasound e ʻike ai i ka pancreas a loaʻa nā laʻana kiko.
• Biopsy: Lawe ʻia kahi laʻana kiko mai ka pancreas a nānā ʻia ma lalo o kahi microscope e hōʻoia i ka loaʻa ʻana o nā maʻi kanesa. Hiki ke hana i kēia i ka wā o ka EUS a i ʻole ka ʻoki ʻana.
• Nā hoʻāʻo koko: Hiki i nā hoʻāʻo koko ke ana i nā pae o kekahi mau mea, e like me CA 19-9, hiki ke hoʻokiʻekiʻe ʻia i nā poʻe me ka maʻi ʻaʻai pancreas. Eia naʻe, ʻaʻole pololei kēia mau hoʻokolohua a hiki ke hoʻokiʻekiʻe ʻia i nā kūlana ʻē aʻe.

Nā koho lapaʻau no Ka maʻi maʻi ʻaʻai pancreas

Lapaʻau no ka maʻi ʻaʻai pancreas pili i ke kahua a me kahi o ka maʻi kanesa, a me ke olakino holoʻokoʻa o ka mea maʻi. Hiki i nā koho ke komo:

ʻO ka ʻoki ʻana

ʻO ka ʻoki ʻana ka lāʻau lapaʻau mua no ka hoʻihoʻi ʻana ka maʻi ʻaʻai pancreas, 'o ia ho'i, hiki ke wehe loa 'ia ke koko. ʻO ke ʻano o ka ʻoki ʻana e pili ana i kahi o ka ʻōpū:

• ʻO ka Whipple Procedure (Pancreaticoduodenectomy): ʻO kēia ʻokiʻoki paʻakikī e pili ana i ka wehe ʻana i ke poʻo o ka pancreas, kahi hapa o ka ʻōpū liʻiliʻi, ka gallbladder, a me kahi hapa o ka pā bile. Hoʻohana maʻamau ia no nā maʻi maʻi ma ke poʻo o ka pancreas.
• Distal Pancreatectomy: ʻO kēia ʻokiʻoki e pili ana i ka wehe ʻana i ka huelo o ka pancreas, a i kekahi manawa ka spleen. Hoʻohana ʻia ia no nā ʻōpū o ka huelo o ka pancreas.
• Total Pancreatectomy: Hoʻopili kēia i ka wehe ʻana i ka pancreas holoʻokoʻa, ʻaʻole i hana ʻia ma muli o ka hopena koʻikoʻi i ka hoʻoponopono ʻana a me ke kō koko.

Kemoterapi

Hoʻohana ʻo Chemotherapy i nā lāʻau lapaʻau e pepehi i nā maʻi kanesa. Hiki ke hoʻohana ʻia ma mua a ma hope paha o ka ʻoki ʻana, a i ʻole ma ke ʻano he lapaʻau mua no ka holomua ka maʻi ʻaʻai pancreas. ʻO nā lāʻau lapaʻau maʻamau i hoʻohana ʻia e mālama ka maʻi ʻaʻai pancreas e komo pū me gemcitabine, paclitaxel, a me fluorouracil (5-FU).

Lapaʻau Radiation

Hoʻohana ka lāʻau lapaʻau i nā kukuna ikaika nui e pepehi i nā maʻi maʻi maʻi. Hiki ke hoʻohana ʻia e hōʻemi i nā maʻi maʻi ma mua o ka ʻoki ʻana, e pepehi i nā keʻena maʻi kanesa i koe ma hope o ke ʻoki ʻana, a i ʻole e hōʻoluʻolu i nā hōʻailona o ka holomua. ka maʻi ʻaʻai pancreas. ʻO ka lāʻau lapaʻau lāʻau waho ke ʻano maʻamau o ka lāʻau lapaʻau i hoʻohana ʻia no ka maʻi ʻaʻai pancreas.

ʻO ka Lapaʻau Kūlohelohe

Hoʻopaʻa ʻia nā lāʻau lapaʻau i hoʻopaʻa ʻia i nā molekole kikoʻī e pili ana i ka ulu ʻana o ka cell cancer a me ke ola. Hiki ke hoʻohana ʻia kēia mau lāʻau i kekahi mau ʻano o ka maʻi ʻaʻai pancreas i loaʻa nā hoʻololi genetic kikoʻī. No ka laʻana, ʻo ka olaparib kahi mea hoʻopale PARP hiki ke hoʻohana ʻia i nā maʻi me nā hoʻololi BRCA.

Immunotherapy

Kōkua ka Immunotherapy i ke kino o ke kino e hakakā i ka maʻi kanesa. ʻAʻole hoʻohana maʻamau no ka maʻi ʻaʻai pancreas akā ke noiʻi ʻia nei ma nā hoʻokolohua lapaʻau. ʻO nā lāʻau lapaʻau immunotherapy e like me pembrolizumab (Keytruda) hiki ke pōmaikaʻi i nā hihia koʻikoʻi o MSI-kiʻekiʻe. ka maʻi ʻaʻai pancreas.

Malama Palliative

Hoʻopili ka mālama palliative i ka hoʻomaha ʻana i nā hōʻailona a me ka hoʻomaikaʻi ʻana i ka maikaʻi o ke ola no ka poʻe me ka holomua ka maʻi ʻaʻai pancreas. Hiki ke komo i ka hoʻoponopono ʻeha, ke kākoʻo meaʻai, a me ke kākoʻo naʻau. Hiki ke hāʻawi ʻia ka mālama palliative i kēlā me kēia pae o ka maʻi ʻaʻai pancreas.

Noho me Ka maʻi maʻi ʻaʻai pancreas

Noho me ka maʻi ʻaʻai pancreas hiki ke paʻakikī, ma ke kino a me ka naʻau. He mea nui ka loaʻa ʻana o kahi ʻōnaehana kākoʻo ikaika, me ka ʻohana, nā hoaaloha, a me nā limahana mālama ola. Hāʻawi ʻo Shandong Baofa Cancer Research Institute i ka ʻike a me nā koho lapaʻau kūpono, e ʻoluʻolu e kamaʻilio me kāu kauka. Hiki ke kōkua pū nā hui kākoʻo a me nā ʻōlelo aʻo i ka hoʻokō ʻana i nā pilikia o ka maʻi ʻaʻai pancreas.

He mea koʻikoʻi nō hoʻi ke kākoʻo ʻai meaʻai no nā poʻe me ka maʻi ʻaʻai pancreas. He koʻikoʻi ko ka pancreas i ka ʻai ʻana, a hiki i ka lāʻau lapaʻau ke hoʻopilikia pinepine i ka hiki ke ʻeli pono i ka meaʻai. ʻO ka hana pū me kahi meaʻai meaʻai i hoʻopaʻa inoa ʻia hiki ke kōkua i ka mālama ʻana i nā pilikia digestive a hōʻoia i ka meaʻai kūpono.

Ka wānana no Ka maʻi maʻi ʻaʻai pancreas

ʻO ka wānana no ka maʻi ʻaʻai pancreas ʻokoʻa ma muli o ka pae o ka maʻi kanesa, ke olakino holoʻokoʻa o ka mea maʻi, a me ka mālama ʻana i loaʻa. ʻO ka ʻike mua ʻana a me ka mālama ʻana he mea koʻikoʻi ia no ka hoʻomaikaʻi ʻana i ka manawa o ke ola. Wahi a ka American Cancer Society, ʻo ka helu ola 5 makahiki no ka localized ka maʻi ʻaʻai pancreas ma kahi o 44%, aʻo ka 5 makahiki ola ola no ka holomua ka maʻi ʻaʻai pancreas ka mea i laha i nā kino mamao ma kahi o 3%. [1]

Nā ho'āʻo hoʻokolohua no Ka maʻi maʻi ʻaʻai pancreas

ʻO nā hoʻokolohua lapaʻau he mau noiʻi noiʻi e noiʻi ana i nā lāʻau lapaʻau hou no ka maʻi ʻaʻai pancreas. ʻO ke komo ʻana i kahi hoʻokolohua lapaʻau hiki ke hāʻawi i ke ala i nā lāʻau lapaʻau ʻokiʻoki ʻaʻole i loaʻa ākea. Inā makemake ʻoe e aʻo hou e pili ana i nā hoʻokolohua lapaʻau no ka maʻi ʻaʻai pancreas, e kamaʻilio me kāu kauka a i ʻole e ʻimi i nā hoʻokolohua ma ka pūnaewele o ka National Cancer Institute. [2]

Hōʻuluʻulu manaʻo

ʻO ka maʻi maʻi pancreas he maʻi koʻikoʻi ia e pono ai ka ʻike koke a me ka mālama ʻana. ʻO ka hoʻomaopopo ʻana i nā kumu pilikia, nā hōʻailona, ​​​​a me nā koho lapaʻau hiki ke kōkua i ka poʻe e hoʻoholo i ka ʻike e pili ana i kā lākou mālama. Ke hoʻomau nei ka noiʻi ʻana a me ka holomua o ka mālama ʻana e hoʻomaikaʻi i ka manaʻo no nā poʻe me ka maʻi ʻaʻai pancreas.

Heluhelu nui a me ka ʻike

[1] ʻAmelika Hui Pū ʻIa: https://www.cancer.org/cancer/types/pancreatic-cancer/detection-diagnosis-staging/survival-rates.html

[2] National Cancer Institute: https://www.cancer.gov/about-cancer/treatment/clinical-trials