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Dr. Yu Baofa thiab ib pab neeg los ntawm Tebchaws Meskas tau luam tawm ib tsab xov xwm hauv Phau Ntawv Qhia Txog Kev Tshawb Fawb Txog Kev Noj Qab Haus Huv thiab Kev Xyaum
2025-02-11 IB
Tus kws kho mob Yu Baofa thiab pab pawg neeg Asmeskas koom ua ke luam tawm tsab xov xwm Kev Ntsuam Xyuas ntawm ntau yam autoantibodies rau qog txuam nrog antigens uas muaj peev xwm kuaj pom tus kab mob qog noj ntshav hauv phau ntawv Journal of Gastroenterology Research thiab Xyaum.
Lub hom phiaj ntawm txoj kev tshawb no yog los soj ntsuam qhov tseem ceeb ntawm kev kho mob ntawm autoantibodies tiv thaiv GNA11, MSLN, GNAS, CEBPA, MDM2, p16, Sui1, Calnuc, PTEN hauv pancreatic cancer (PC). Tag nrho ntawm 33 cov qauv kuaj ntshav los ntawm cov neeg mob PC thiab 45 cov qauv kuaj ntshav los ntawm kev tswj ib txwm muaj (NC) tau suav nrog, thiab 9 hom autoantibodies tau kuaj pom siv enzyme-txuas immunosorbent assay (ELISA). Ntsuam xyuas siv ntau yam tsis muaj nyob rau hauv ib tug neeg los yog ua ke daim ntawv. Tsuas yog cov tshuaj tiv thaiv GNAS thiab tshuaj tiv thaiv calNUC, qib ntawm tag nrho lwm cov autoantibodies tau nce siab dua li cov hauv pawg tswj hwm ib txwm muaj. Piv nrog rau pawg tswj hwm ib txwm muaj (4.9%), qhov zaus ntawm plaub lub autoantibodies, MSLN, p16, PTEN, thiab Sui1, nce ntxiv, ntawm 75.8%, 66.7%, 30.3%, thiab 27.3%, feem. Lub peev xwm ntawm cov autoantibodies kom paub qhov txawv ntawm thaj chaw nyob rau hauv ROC nkhaus (AUC) thaj tsam ntawm 0.666 txog 0.884, nrog anti-p16 (AUC ntawm 0.884) thiab anti MSLN (AUC ntawm 0.857) nthuav tawm qhov kev kuaj mob zoo tshaj plaws. Kev sib xyaw ntawm anti-MSLN thiab anti-p16 tuaj yeem txhim kho qhov rhiab heev ntawm kev kuaj mob.
Tsis tas li ntawd, ob qho tib si MSLN thiab Sui1 autoantibodies txo qis hauv PC cov neeg mob tom qab siv tshuaj khomob. Plaub autoantibodies tiv thaiv MSLN, p16, Sui1 thiab PTEN tau pom muaj peev xwm kuaj xyuas cov cim rau kab mob qog noj ntshav, ntawm cov tshuaj tiv thaiv MSLN thiab anti p16 yog qhov zoo tshaj plaws. Kev sib xyaw ua ke ntawm ob lub autoantibodies no qhia tau tias muaj kev lag luam zoo tshaj plaws thiab muaj peev xwm siv tau. Qhov tseem ceeb ntawm kev txo qis autoantibodies tawm tsam MSLN thiab Sui1 hauv PC cov neeg mob tom qab siv tshuaj kho mob xav tau kev tshawb nrhiav ntxiv.
Cov kev tshawb fawb ntawm cov qog nqaij hlav ntsig txog autoantibodies muab cov ntaub ntawv tseem ceeb rau kev kuaj ntxov, kuaj mob, thiab kho cov qog. Academician Yu Baofa siv cov qog autoantibodies hauv kev kho mob qog ntau tshaj 20 xyoo dhau los.
