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UDkt. Yu Baofa kanye nethimba elivela e-United States bashicilele isihloko ku-Journal of Gastroenterology Research and Practice
2025-02-11
UDokotela u-Yu Baofa kanye nethimba laseMelika ngokuhlanganyela bashicilele indatshana ethi Ukuhlolwa kwama-autoantibodies amaningi kuma-antigen ahlobene nesimila njengezimpawu ezingaba khona zokuxilonga umdlavuza we-pancreatic ku-Journal of Gastroenterology Research and Practice.
Inhloso yalolu cwaningo kwakuwukuhlola ukubaluleka komtholampilo kwama-autoantibodies ngokumelene ne-GNA11, MSLN, GNAS, CEBPA, MDM2, p16, Sui1, Calnuc, PTEN kumdlavuza we-pancreatic (PC). Isamba samasampula e-serum angu-33 avela ezigulini ze-PC kanye namasampula e-serum angu-45 avela kuzilawuli ezivamile (NC) afakiwe, futhi izinhlobo ezingu-9 zama-autoantibodies zitholwe kusetshenziswa i-enzyme-linked immunosorbent assay (ELISA). Linganisa usebenzisa amapharamitha amaningi ngendlela eyodwa noma ehlanganisiwe. Ngaphandle kwe-anti GNAS kanye ne-anti calNUC, amazinga awo wonke amanye ama-autoantibodies ayephezulu kakhulu kunalawo aseqenjini elivamile lokulawula. Uma kuqhathaniswa neqembu elijwayelekile lokulawula (4.9%), ama-autoantibodies amane, i-MSLN, i-p16, i-PTEN, ne-Sui1, akhuphuke kakhulu, ngo-75.8%, 66.7%, 30.3%, no-27.3%, ngokulandelana. Amandla alawa ma-autoantibodies okuhlukanisa indawo engaphansi kwejika le-ROC (AUC) asuka ku-0.666 kuye ku-0.884, ane-anti-p16 (AUC ka-0.884) kanye ne-anti MSLN (AUC ka-0.857) ebonisa ukusebenza kokuxilonga okuqine kakhulu. Inhlanganisela ye-anti-MSLN ne-anti-p16 ingathuthukisa ukuzwela kokuxilongwa.
Ngaphezu kwalokho, kokubili i-MSLN ne-Sui1 autoantibodies yehle ezigulini ze-PC ngemva kokwelashwa ngamakhemikhali. Amasosha omzimba amane amelene ne-MSLN, p16, Sui1 kanye ne-PTEN abonise izimpawu zokuxilonga ezingase zibe khona zomdlavuza we-pancreatic, lapho i-anti MSLN kanye ne-anti p16 bekungcono kakhulu. Inhlanganisela yalawa ma-autoantibodies amabili ibonisa amandla ayonga kakhulu futhi angokoqobo. Ukubaluleka kokuncipha kwama-autoantibodies ngokumelene ne-MSLN ne-Sui1 ezigulini ze-PC ngemva kokwelashwa ngamakhemikhali kudinga ukuhlolwa okwengeziwe.
Ucwaningo lwama-autoantibodies ahlobene nesimila lunikeza ireferensi ebalulekile yokuhlolwa kusenesikhathi, ukuxilonga, nokwelashwa kwamathumba. Isazi sezemfundo u-Yu Baofa sasebenzisa amasosha omzimba ethumba ekwelapheni isimila eminyakeni engaphezu kwengu-20 edlule.
