Dr. Yu Baofa ndi gulu lochokera ku United States adasindikiza nkhani mu Journal of Gastroenterology Research and Practice

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 Dr. Yu Baofa ndi gulu lochokera ku United States adasindikiza nkhani mu Journal of Gastroenterology Research and Practice 

2025-02-11

Doctor Yu Baofa ndi gulu la ku America anasindikiza pamodzi nkhani yakuti Kuwunika kwa ma autoantibodies angapo ku antigens okhudzana ndi zotupa monga zozindikiritsa za khansa ya kapamba mu Journal of Gastroenterology Research and Practice.

Cholinga cha phunziroli chinali kuyesa kufunika kwachipatala kwa autoantibodies motsutsana ndi GNA11, MSLN, GNAS, CEBPA, MDM2, p16, Sui1, Calnuc, PTEN mu khansa ya pancreatic (PC). Zitsanzo zonse za 33 za seramu kuchokera kwa odwala PC ndi zitsanzo za 45 za seramu kuchokera ku machitidwe abwino (NC) zinaphatikizidwa, ndipo mitundu ya 9 ya autoantibodies inapezedwa pogwiritsa ntchito enzyme-linked immunosorbent assay (ELISA). Yesani kugwiritsa ntchito magawo angapo paokha kapena kuphatikiza. Kupatula anti GNAS ndi anti calNUC, milingo ya ma autoantibodies ena onse anali okwera kwambiri kuposa omwe ali mgulu lowongolera. Poyerekeza ndi gulu lowongolera (4.9%), ma frequency a autoantibodies anayi, MSLN, p16, PTEN, ndi Sui1, adakwera kwambiri, pa 75.8%, 66.7%, 30.3%, ndi 27.3%, motsatana. Kuthekera kwa ma autoantibodies awa kusiyanitsa malo omwe ali pansi pa ROC curve (AUC) kuyambira 0.666 mpaka 0.884, ndi anti-p16 (AUC ya 0.884) ndi anti MSLN (AUC ya 0.857) yomwe ikuwonetsa magwiridwe antchito amphamvu kwambiri. Kuphatikiza kwa anti-MSLN ndi anti-p16 kumatha kukulitsa chidwi cha matenda.

Kuphatikiza apo, onse a MSLN ndi Sui1 autoantibodies adachepa mwa odwala PC pambuyo pa chemotherapy. Ma autoantibodies anayi motsutsana ndi MSLN, p16, Sui1 ndi PTEN adawonetsa zozindikiritsa za khansa ya kapamba, zomwe anti MSLN ndi anti p16 zinali zabwino kwambiri. Kuphatikizika kwa ma autoantibodies awiriwa kukuwonetsa kuthekera kwachuma komanso kothandiza. Kufunika kwa kuchepa kwa ma autoantibodies motsutsana ndi MSLN ndi Sui1 mwa odwala a PC pambuyo pa chemotherapy kumafunikira kufufuza kwina.

Kafukufuku wokhudzana ndi ma autoantibodies okhudzana ndi chotupa amapereka chidziwitso chofunikira pakuwunika koyambirira, kuzindikira, komanso kuchiza zotupa. Katswiri wamaphunziro Yu Baofa adagwiritsa ntchito ma autoantibodies a tumor mu chithandizo cha chotupa zaka zoposa 20 zapitazo.

Kunyumba
Milandu Yodziwika
Zambiri zaife
Lumikizanani nafe

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