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Dr. Yu Baofa na otu ndị si United States bipụtara otu akụkọ na Journal of Gastroenterology Research and Practice
2025-02-11
Dọkịta Yu Baofa na ndị otu America jikọtara ọnụ bipụta akụkọ nyocha nke ọtụtụ autoantibodies na antigens metụtara etuto dị ka ihe nwere ike ịchọpụta ọrịa kansa pancreatic na Journal of Gastroenterology Research and Practice.
Ebumnuche nke ọmụmụ a bụ iji nyochaa mkpa ụlọ ọgwụ nke autoantibodies megide GNA11, MSLN, GNAS, CEBPA, MDM2, p16, Sui1, Calnuc, PTEN na ọrịa cancer pancreatic (PC). Ngụkọta nke 33 serum samples sitere na ndị ọrịa PC na 45 serum samples sitere na njikwa nkịtị (NC) gụnyere, na ụdị 9 nke autoantibodies achọpụtara site na iji enzyme-linked immunosorbent assay (ELISA). Nyochaa iji otutu paramita n'ụdị nke ọ bụla ma ọ bụ jikọtara ọnụ. Ewezuga mgbochi GNAS na mgbochi calNUC, ọkwa nke autoantibodies ndị ọzọ dị elu nke ukwuu karịa ndị nọ na otu njikwa nkịtị. E jiri ya tụnyere otu njikwa nkịtị (4.9%), ugboro ugboro nke autoantibodies anọ, MSLN, p16, PTEN, na Sui1, mụbara nke ukwuu, na 75.8%, 66.7%, 30.3%, na 27.3%, n'otu n'otu. Ikike nke autoantibodies ndị a ịmata ọdịiche dị n'okpuru ROC curve (AUC) sitere na 0.666 ruo 0.884, yana mgbochi p16 (AUC nke 0.884) na mgbochi MSLN (AUC nke 0.857) na-egosipụta arụmọrụ nchọpụta kachasị ike. Nchikota mgbochi MSLN na mgbochi p16 nwere ike imeziwanye nghọta nke nchoputa.
Na mgbakwunye, ma MSLN na Sui1 autoantibodies belatara na ndị ọrịa PC mgbe chemotherapy gasịrị. Ihe mgbochi autoantibodies anọ megide MSLN, p16, Sui1 na PTEN gosipụtara ihe nrịbama nwere ike ịchọpụta ọrịa kansa pancreatic, nke mgbochi MSLN na mgbochi p16 kacha mma. Nchikota nke autoantibodies abụọ a na-egosipụta ike kachasị mma na nke bara uru. Ihe mbelata autoantibodies megide MSLN na Sui1 na PC ndị ọrịa mgbe chemotherapy gachara chọrọ nyocha ọzọ.
Nnyocha e mere na autoantibodies metụtara tumor na-enye ntụaka dị mkpa maka nyocha mmalite, nchọpụta, na ọgwụgwọ nke etuto ahụ. Ọkammụta Yu Baofa tinyere akpụ autoantibodies na ọgwụgwọ akpụ ihe karịrị afọ 20 gara aga.
