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Dr. Yu Baofa uye Chikwata chinobva kuUnited States chakaburitsa chinyorwa mune chinyorwa chekutsvaga kweGastroenterology kutsvagisa uye kudzidzira
2025-02-16
Doctor Yu Baofa uye Chikwata cheAmerica chakaburitsa chinyorwa chekuongororwa kwechinyorwa chevazhinji veTumor zvakabatana nekananisi yePancreate
Chinangwa cheichi chidzidzo chaive chekuongorora kiriniki kukosha kwe autoantiboys kurwisa GNA11, MSLN, GNAS, MDM2, P16, Suyi Azere makumi matatu nemaseramu sampuli kubva kuPC varwere uye makumi mana Serum sampuli kubva kuyakajairika kudzora Ongorora uchishandisa akawanda parameter mune imwe yemunhu kana yakasanganiswa fomu. Kunze kweAnti Gnas neAnti Calnuc, mazinga ezvimwe zvese autoantibodies aive akanyanya kukwirisa kupfuura idzo dziri muboka rechokwadi. Kuenzaniswa neiyo yakajairika boka reCront (4.9%), mafambiro evana mana autoantibodies, MSLN, PTTEN, uye Sui1, 66.7%, 30.3%, uye 27.3%, zvichiteerana. Kugona kweaya autoantibos ekusiyanisa nharaunda pasi peRoc Curve (AUC) kubva pa0,884, AUC ye 0.884 Iko kusanganiswa kwe anti-msln uye anti-p10 kunogona kuvandudza kuongororwa kwekuongororwa.
Uye zvakare, msln uye sui1 autoantiboys yakadzikira muPC varwere mushure memotherapy. Ina Outanti Booss Autnic, P16, Suyi1 uye Pten yakaratidza zvinogona kuongorora maCancer, iyo Anti MSLN neAnti P16 yaive yakanyanya kunaka. Iko kusanganiswa kweaya maviri autoantiboys anoratidza zvakanyanya hupfumi uye zvinoshanda kugona. Iko kukosha kwekushandurwa kweToantiesboys kurwisa MSLN uye Sui1 muPC varwere mushure memake chemotherapy achida kuwanda.
Tsvagurudzo pane tumor ine chekuita neutantiodies inopa kukosha kwakakosha kwekutanga kwekutarisa, kuongororwa, uye kurapwa kwemapundu. Academician yu baoma yakaiswa tumor autoantiboes muTumor kurapwa zvinopfuura makore makumi maviri apfuura.
