Dr. Yu Baofa n'itsinda ryaturutse muri Amerika basohoye inkuru mu kinyamakuru cya Gastroenterology Research and Practice

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 Dr. Yu Baofa n'itsinda ryaturutse muri Amerika basohoye inkuru mu kinyamakuru cya Gastroenterology Research and Practice 

2025-02-11

Muganga Yu Baofa hamwe nitsinda ryabanyamerika basohoye ingingo yisuzuma Isuzuma ryimodoka nyinshi ziterwa na kanseri ifata antigene nkibimenyetso byerekana indwara ya kanseri yandura mu kinyamakuru cya Gastroenterology Research and Practice.

Icyari kigamijwe muri ubu bushakashatsi kwari ugusuzuma akamaro k’amavuriro ya autoantibodies irwanya GNA11, MSLN, GNAS, CEBPA, MDM2, p16, Sui1, Calnuc, PTEN muri kanseri yandura (PC). Harimo urugero rwa serumu 33 z’abarwayi ba PC hamwe na 45 za serumu ziva mu igenzura risanzwe (NC), kandi ubwoko 9 bwa ​​autoantibodies bwagaragaye hakoreshejwe enzyme ifitanye isano na immunosorbent (ELISA). Suzuma ukoresheje ibipimo byinshi muburyo bwihariye cyangwa bwahujwe. Usibye kurwanya GNAS na anti calNUC, urwego rwizindi autoantibodies zose zari hejuru cyane ugereranije nabari mumatsinda asanzwe agenzura. Ugereranije nitsinda risanzwe rishinzwe kugenzura (4.9%), inshuro enye za autoantibodies, MSLN, p16, PTEN, na Sui1, ziyongereye cyane, kuri 75.8%, 66.7%, 30.3%, na 27.3%. Ubushobozi bwiyi autoantibodies yo gutandukanya agace kari munsi yumurongo wa ROC (AUC) kiva kuri 0.666 kugeza 0.884, hamwe na anti-p16 (AUC ya 0.884) na anti MSLN (AUC ya 0.857) yerekana imikorere ikomeye yo gusuzuma. Guhuza anti-MSLN na anti-p16 birashobora kunoza sensibilité yo gusuzuma.

Byongeye kandi, autoantibodies ya MSLN na Sui1 yagabanutse ku barwayi ba PC nyuma ya chimiotherapie. Imodoka enye zirwanya MSLN, p16, Sui1 na PTEN zerekanye ibimenyetso bishobora gupima kanseri yandura, muri zo anti MSLN na anti p16 nibyo byiza. Guhuza izi autoantibodies zombi byerekana ubushobozi bwubukungu kandi bufatika. Akamaro ko kugabanuka kwa autoantibodies kurwanya MSLN na Sui1 kubarwayi ba PC nyuma ya chimiotherapie ikeneye ubundi bushakashatsi.

Ubushakashatsi kuri autoantibodies yibibyimba butanga ibisobanuro byingenzi mugupima hakiri kare, gusuzuma, no kuvura ibibyimba. Umunyeshuri Yu Baofa yakoresheje ibibyimba autoantibodies mu kuvura ibibyimba hashize imyaka irenga 20.

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