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Ngaka Yu Baofa le sehlopha se tsoang United States ba phatlalalitse sengoloa ho Journal of Gastroenterology Research and Practice.
2025-02-11
Ngaka Yu Baofa le sehlopha sa Amerika ka kopanelo ba phatlalalitse sengoloa sa Tlhahlobo ea li-autoantibodies tse ngata ho li-antigen tse amanang le tumor e le matšoao a ka bang teng a ho hlahloba mofetše oa pancreatic ho Journal of Gastroenterology Research and Practice.
Sepheo sa thuto ena e ne e le ho hlahloba bohlokoa ba kliniki ba li-autoantibodies khahlanong le GNA11, MSLN, GNAS, CEBPA, MDM2, p16, Sui1, Calnuc, PTEN ka kankere ea pancreatic (PC). Kakaretso ea li-samples tsa serum tse 33 tse tsoang ho bakuli ba PC le li-samples tsa 45 tsa serum tse tsoang ho li-control tse tloaelehileng (NC) li kenyelelitsoe, 'me mefuta ea 9 ea li-autoantibodies e ile ea fumanoa ho sebelisoa enzyme-linked immunosorbent assay (ELISA). Lekola ho sebelisa liparamente tse ngata ka mokhoa o le mong kapa o kopaneng. Ntle le anti GNAS le anti calNUC, maemo a li-autoantibodies tse ling kaofela a ne a phahame haholo ho feta a sehlopha se tloaelehileng sa taolo. Ha ho bapisoa le sehlopha se tloaelehileng sa taolo (4.9%), maqhubu a li-autoantibodies tse 'nè, MSLN, p16, PTEN, le Sui1, a eketsehile haholo, ho 75.8%, 66.7%, 30.3%, le 27.3%, ka ho latellana. Bokhoni ba li-autoantibodies tsena ho khetholla sebaka se tlas'a ROC curve (AUC) ho tloha ho 0.666 ho ea ho 0.884, ka anti-p16 (AUC ea 0.884) le anti MSLN (AUC ea 0.857) e bontšang ts'ebetso e matla ka ho fetisisa ea ho hlahloba. Motsoako oa anti-MSLN le anti-p16 o ka ntlafatsa kutloisiso ea tlhahlobo.
Ntle le moo, li-autoantibodies tsa MSLN le Sui1 li fokotsehile ho bakuli ba PC kamora chemotherapy. Li-autoantibodies tse 'ne khahlano le MSLN, p16, Sui1 le PTEN li bontšitse matšoao a ka bang teng a ho hlahloba mofetše oa pancreatic, oo anti MSLN le anti p16 e neng e le tsona tse ntle ka ho fetisisa. Motsoako oa li-autoantibodies tsena tse peli o bonts'a bokhoni ba moruo le bo sebetsang ka ho fetesisa. Bohlokoa ba ho fokotseha ha li-autoantibodies khahlanong le MSLN le Sui1 ho bakuli ba PC ka mor'a chemotherapy ho hloka tlhahlobo e eketsehileng.
Patlisiso e mabapi le li-autoantibodies tse amanang le tumor e fana ka tšupiso ea bohlokoa bakeng sa tlhahlobo ea pele, tlhahlobo le kalafo ea lihlahala. Setsebi sa thuto Yu Baofa se sebelisitse tumor autoantibodies kalafong ea tumor ho feta lilemo tse 20 tse fetileng.
