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Dokita Yu Baofa ati ẹgbẹ kan lati Ilu Amẹrika ṣe atẹjade nkan kan ninu Iwe Iroyin ti Iwadi ati Iṣewadii Gastroenterology
2025-02-11
Dọkita Yu Baofa ati ẹgbẹ Amẹrika ni apapọ ṣe atẹjade nkan naa Igbelewọn ti ọpọlọpọ awọn autoantibodies si awọn antigens ti o ni ibatan tumo bi awọn ami idanimọ ti o pọju fun akàn pancreatic ninu Iwe akọọlẹ ti Iwadi ati adaṣe Gastroenterology.
Idi ti iwadi yii ni lati ṣe iṣiro pataki ile-iwosan ti awọn autoantibodies lodi si GNA11, MSLN, GNAS, CEBPA, MDM2, p16, Sui1, Calnuc, PTEN ni akàn pancreatic (PC). Lapapọ ti awọn ayẹwo omi ara 33 lati awọn alaisan PC ati awọn ayẹwo omi ara 45 lati awọn iṣakoso deede (NC) wa ninu, ati pe awọn oriṣi 9 ti autoantibodies ni a rii nipa lilo assay immunosorbent assay (ELISA). Ṣe ayẹwo nipa lilo awọn paramita pupọ ni ẹni kọọkan tabi fọọmu apapọ. Ayafi fun egboogi GNAS ati egboogi calNUC, awọn ipele ti gbogbo awọn autoantibodies miiran jẹ pataki ti o ga ju awọn ti o wa ninu ẹgbẹ iṣakoso deede. Ti a ṣe afiwe pẹlu ẹgbẹ iṣakoso deede (4.9%), awọn igbohunsafẹfẹ ti awọn autoantibodies mẹrin, MSLN, p16, PTEN, ati Sui1, pọ si ni pataki, ni 75.8%, 66.7%, 30.3%, ati 27.3%, lẹsẹsẹ. Agbara ti awọn autoantibodies wọnyi lati ṣe iyatọ agbegbe ti o wa labẹ igun ROC (AUC) wa lati 0.666 si 0.884, pẹlu anti-p16 (AUC ti 0.884) ati anti MSLN (AUC ti 0.857) ti n ṣe afihan iṣẹ ṣiṣe iwadii ti o lagbara julọ. Apapo egboogi-MSLN ati anti-p16 le mu ifamọ ti ayẹwo sii.
Ni afikun, mejeeji MSLN ati Sui1 autoantibodies dinku ni awọn alaisan PC lẹhin chemotherapy. Awọn autoantibodies mẹrin ti o lodi si MSLN, p16, Sui1 ati PTEN ṣe afihan awọn ami idanimọ ti o pọju fun akàn pancreatic, eyiti anti MSLN ati anti p16 jẹ eyiti o dara julọ. Ijọpọ ti awọn autoantibodies meji wọnyi ṣe afihan ti ọrọ-aje julọ ati agbara iṣe. Pataki ti idinku awọn autoantibodies lodi si MSLN ati Sui1 ni awọn alaisan PC lẹhin kimoterapi nilo iwadii siwaju sii.
Iwadi lori awọn autoantibodies ti o ni ibatan tumo n pese itọkasi pataki fun ibojuwo kutukutu, iwadii aisan, ati itọju awọn èèmọ. Omowe Yu Baofa lo awọn autoantibodies tumo ninu itọju tumo diẹ sii ju 20 ọdun sẹyin.
